Research progress on the role of glutamine metabolism-related proteins in tumor metastasis
Tumor metastasis is closely related to high mortality rate of cancer. It is well known that glutamine plays an important role in the malignant progression of cancer. Notably, as an important carbon and nitrogen donor, glutamine has been found to be closely related to tumor metastasis in recent years...
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| Format: | Article |
| Language: | English |
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Editorial Office of China Oncology
2024-01-01
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| Series: | Zhongguo aizheng zazhi |
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| Online Access: | http://www.china-oncology.com/fileup/1007-3639/PDF/1707102110692-1475334474.pdf |
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| author | LIU Xuerou, YANG Yumei, ZHAO Qian, RONG Xiangyu, LIU Wei, ZHENG Ruijie, PANG Jinlong, LI Xian, LI Shanshan |
| author_facet | LIU Xuerou, YANG Yumei, ZHAO Qian, RONG Xiangyu, LIU Wei, ZHENG Ruijie, PANG Jinlong, LI Xian, LI Shanshan |
| author_sort | LIU Xuerou, YANG Yumei, ZHAO Qian, RONG Xiangyu, LIU Wei, ZHENG Ruijie, PANG Jinlong, LI Xian, LI Shanshan |
| collection | DOAJ |
| description | Tumor metastasis is closely related to high mortality rate of cancer. It is well known that glutamine plays an important role in the malignant progression of cancer. Notably, as an important carbon and nitrogen donor, glutamine has been found to be closely related to tumor metastasis in recent years. Glutamine is not only involved in regulating the proliferation of tumor cells, but is also closely related to the migration and invasion of tumor cells. Furthermore, various enzymes along with transporters in the metabolism of glutamine are involved in the process of tumor metastasis through different signaling pathways. This review provided a summary of the role of glutamine in tumor metastasis in recent years and proposed therapeutic targets to provide new strategies for the clinical treatment of tumor metastases. |
| first_indexed | 2024-03-07T23:04:42Z |
| format | Article |
| id | doaj.art-ffdc370ef47c42b1b488420f1765cb3b |
| institution | Directory Open Access Journal |
| issn | 1007-3639 |
| language | English |
| last_indexed | 2024-03-07T23:04:42Z |
| publishDate | 2024-01-01 |
| publisher | Editorial Office of China Oncology |
| record_format | Article |
| series | Zhongguo aizheng zazhi |
| spelling | doaj.art-ffdc370ef47c42b1b488420f1765cb3b2024-02-22T06:28:59ZengEditorial Office of China OncologyZhongguo aizheng zazhi1007-36392024-01-013419710310.19401/j.cnki.1007-3639.2024.01.007Research progress on the role of glutamine metabolism-related proteins in tumor metastasisLIU Xuerou, YANG Yumei, ZHAO Qian, RONG Xiangyu, LIU Wei, ZHENG Ruijie, PANG Jinlong, LI Xian, LI Shanshan01. School of Pharmacy, Bengbu Medical University, Bengbu 233030, Anhui Province, China;2. Anhui Provincial Engineering Technology Research Center of Biochemical Pharmaceuticals, Bengbu 233030, Anhui Province, ChinaTumor metastasis is closely related to high mortality rate of cancer. It is well known that glutamine plays an important role in the malignant progression of cancer. Notably, as an important carbon and nitrogen donor, glutamine has been found to be closely related to tumor metastasis in recent years. Glutamine is not only involved in regulating the proliferation of tumor cells, but is also closely related to the migration and invasion of tumor cells. Furthermore, various enzymes along with transporters in the metabolism of glutamine are involved in the process of tumor metastasis through different signaling pathways. This review provided a summary of the role of glutamine in tumor metastasis in recent years and proposed therapeutic targets to provide new strategies for the clinical treatment of tumor metastases.http://www.china-oncology.com/fileup/1007-3639/PDF/1707102110692-1475334474.pdf|glutamine metabolism|tumor metastasis|epithelial-mesenchymal transition|targeted therapy |
| spellingShingle | LIU Xuerou, YANG Yumei, ZHAO Qian, RONG Xiangyu, LIU Wei, ZHENG Ruijie, PANG Jinlong, LI Xian, LI Shanshan Research progress on the role of glutamine metabolism-related proteins in tumor metastasis Zhongguo aizheng zazhi |glutamine metabolism|tumor metastasis|epithelial-mesenchymal transition|targeted therapy |
| title | Research progress on the role of glutamine metabolism-related proteins in tumor metastasis |
| title_full | Research progress on the role of glutamine metabolism-related proteins in tumor metastasis |
| title_fullStr | Research progress on the role of glutamine metabolism-related proteins in tumor metastasis |
| title_full_unstemmed | Research progress on the role of glutamine metabolism-related proteins in tumor metastasis |
| title_short | Research progress on the role of glutamine metabolism-related proteins in tumor metastasis |
| title_sort | research progress on the role of glutamine metabolism related proteins in tumor metastasis |
| topic | |glutamine metabolism|tumor metastasis|epithelial-mesenchymal transition|targeted therapy |
| url | http://www.china-oncology.com/fileup/1007-3639/PDF/1707102110692-1475334474.pdf |
| work_keys_str_mv | AT liuxuerouyangyumeizhaoqianrongxiangyuliuweizhengruijiepangjinlonglixianlishanshan researchprogressontheroleofglutaminemetabolismrelatedproteinsintumormetastasis |