Effects of Hypericum Perforatum, in a rodent model of periodontitis
<p>Abstract</p> <p>Background</p> <p><it>Hypericum perforatum </it>is a medicinal plant species containing many polyphenolic compounds, namely flavonoids and phenolic acids. In this study we evaluate the effect of <it>Hypericum perforatum </it>in...
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| Format: | Article |
| Language: | English |
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BMC
2010-11-01
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| Series: | BMC Complementary and Alternative Medicine |
| Online Access: | http://www.biomedcentral.com/1472-6882/10/73 |
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| author | Cordasco Giancarlo Oteri Giacomo Galuppo Maria Mazzon Emanuela Briguglio Enrico Paterniti Irene Cuzzocrea Salvatore |
| author_facet | Cordasco Giancarlo Oteri Giacomo Galuppo Maria Mazzon Emanuela Briguglio Enrico Paterniti Irene Cuzzocrea Salvatore |
| author_sort | Cordasco Giancarlo |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p><it>Hypericum perforatum </it>is a medicinal plant species containing many polyphenolic compounds, namely flavonoids and phenolic acids. In this study we evaluate the effect of <it>Hypericum perforatum </it>in animal model of periodontitis.</p> <p>Methods</p> <p>Periodontitis was induced in adult male Sprague-Dawley rats by placing a nylon thread ligature around the lower 1st molars. Hypericum perforatum was administered at the dose of 2 mg/kg os, daily for eight days. At day 8, the gingivomucosal tissue encircling the mandibular first molar was removed.</p> <p>Results</p> <p>Periodontitis in rats resulted in an inflammatory process characterized by edema, neutrophil infiltration and cytokine production that was followed by the recruitment of other inflammatory cells, production of a range of inflammatory mediators such as NF-κB and iNOS expression, the nitration of tyrosine residues and activation of the nuclear enzyme poly (ADP-ribose) polymerase; apoptosis and the degree of gingivomucosal tissues injury. We report here that Hypericum perforatum exerts potent anti-inflammatory effects significantly reducing all of the parameters of inflammation as described above.</p> <p>Conclusions</p> <p>Taken together, our results clearly demonstrate that treatment with Hypericum reduces the development of inflammation and tissue injury, events associated with periodontitis.</p> |
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| format | Article |
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| institution | Directory Open Access Journal |
| issn | 1472-6882 |
| language | English |
| last_indexed | 2024-12-18T19:34:16Z |
| publishDate | 2010-11-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Complementary and Alternative Medicine |
| spelling | doaj.art-ffdee05befaa4495a6150c4ec0a8511e2022-12-21T20:55:39ZengBMCBMC Complementary and Alternative Medicine1472-68822010-11-011017310.1186/1472-6882-10-73Effects of Hypericum Perforatum, in a rodent model of periodontitisCordasco GiancarloOteri GiacomoGaluppo MariaMazzon EmanuelaBriguglio EnricoPaterniti IreneCuzzocrea Salvatore<p>Abstract</p> <p>Background</p> <p><it>Hypericum perforatum </it>is a medicinal plant species containing many polyphenolic compounds, namely flavonoids and phenolic acids. In this study we evaluate the effect of <it>Hypericum perforatum </it>in animal model of periodontitis.</p> <p>Methods</p> <p>Periodontitis was induced in adult male Sprague-Dawley rats by placing a nylon thread ligature around the lower 1st molars. Hypericum perforatum was administered at the dose of 2 mg/kg os, daily for eight days. At day 8, the gingivomucosal tissue encircling the mandibular first molar was removed.</p> <p>Results</p> <p>Periodontitis in rats resulted in an inflammatory process characterized by edema, neutrophil infiltration and cytokine production that was followed by the recruitment of other inflammatory cells, production of a range of inflammatory mediators such as NF-κB and iNOS expression, the nitration of tyrosine residues and activation of the nuclear enzyme poly (ADP-ribose) polymerase; apoptosis and the degree of gingivomucosal tissues injury. We report here that Hypericum perforatum exerts potent anti-inflammatory effects significantly reducing all of the parameters of inflammation as described above.</p> <p>Conclusions</p> <p>Taken together, our results clearly demonstrate that treatment with Hypericum reduces the development of inflammation and tissue injury, events associated with periodontitis.</p>http://www.biomedcentral.com/1472-6882/10/73 |
| spellingShingle | Cordasco Giancarlo Oteri Giacomo Galuppo Maria Mazzon Emanuela Briguglio Enrico Paterniti Irene Cuzzocrea Salvatore Effects of Hypericum Perforatum, in a rodent model of periodontitis BMC Complementary and Alternative Medicine |
| title | Effects of Hypericum Perforatum, in a rodent model of periodontitis |
| title_full | Effects of Hypericum Perforatum, in a rodent model of periodontitis |
| title_fullStr | Effects of Hypericum Perforatum, in a rodent model of periodontitis |
| title_full_unstemmed | Effects of Hypericum Perforatum, in a rodent model of periodontitis |
| title_short | Effects of Hypericum Perforatum, in a rodent model of periodontitis |
| title_sort | effects of hypericum perforatum in a rodent model of periodontitis |
| url | http://www.biomedcentral.com/1472-6882/10/73 |
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