NIR is a nucleolar RNA-binding protein that is involved in cell proliferation
A novel inhibitor of histone acetyltransferase repressor (NIR) is a histone acetylation inhibitor that associates with p53, p63 and histone complexes. Staining with anti-NIR antibodies revealed that the protein is localized at the nucleolus. The nucleolar localization of NIR was lost upon RNase...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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University of Belgrade, University of Novi Sad
2013-01-01
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| Series: | Archives of Biological Sciences |
| Subjects: | |
| Online Access: | http://www.doiserbia.nb.rs/img/doi/0354-4664/2013/0354-46641303929K.pdf |
| _version_ | 1828298080360857600 |
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| author | Kang Min Kook Han Seung Jin |
| author_facet | Kang Min Kook Han Seung Jin |
| author_sort | Kang Min Kook |
| collection | DOAJ |
| description | A novel inhibitor of histone acetyltransferase repressor (NIR) is a histone acetylation inhibitor that associates with p53, p63 and histone complexes. Staining with anti-NIR antibodies revealed that the protein is localized at the nucleolus. The nucleolar localization of NIR was lost upon RNase treatment, whereas its localization was unaffected by treatment with DNase. These results indicate that NIR directly or indirectly binds RNA in the nucleolus. The expression of NIR protein was higher in cancer cell lines than in non-cancer cell lines. The proliferation rate of human embryonic kidney 293T cells was higher following the ectopic expression of NIR than following the ectopic expression of green fluorescent protein (GFP). In summary, NIR is an RNA-associated protein that is involved in the cell proliferation regulation. |
| first_indexed | 2024-04-13T12:35:57Z |
| format | Article |
| id | doaj.art-ffdf0cfe2a3048699e8613290d606e4f |
| institution | Directory Open Access Journal |
| issn | 0354-4664 1821-4339 |
| language | English |
| last_indexed | 2024-04-13T12:35:57Z |
| publishDate | 2013-01-01 |
| publisher | University of Belgrade, University of Novi Sad |
| record_format | Article |
| series | Archives of Biological Sciences |
| spelling | doaj.art-ffdf0cfe2a3048699e8613290d606e4f2022-12-22T02:46:40ZengUniversity of Belgrade, University of Novi SadArchives of Biological Sciences0354-46641821-43392013-01-0165392993710.2298/ABS1303929KNIR is a nucleolar RNA-binding protein that is involved in cell proliferationKang Min KookHan Seung JinA novel inhibitor of histone acetyltransferase repressor (NIR) is a histone acetylation inhibitor that associates with p53, p63 and histone complexes. Staining with anti-NIR antibodies revealed that the protein is localized at the nucleolus. The nucleolar localization of NIR was lost upon RNase treatment, whereas its localization was unaffected by treatment with DNase. These results indicate that NIR directly or indirectly binds RNA in the nucleolus. The expression of NIR protein was higher in cancer cell lines than in non-cancer cell lines. The proliferation rate of human embryonic kidney 293T cells was higher following the ectopic expression of NIR than following the ectopic expression of green fluorescent protein (GFP). In summary, NIR is an RNA-associated protein that is involved in the cell proliferation regulation.http://www.doiserbia.nb.rs/img/doi/0354-4664/2013/0354-46641303929K.pdfcell cyclecell proliferationNIRnucleolusRNA-binding protein |
| spellingShingle | Kang Min Kook Han Seung Jin NIR is a nucleolar RNA-binding protein that is involved in cell proliferation Archives of Biological Sciences cell cycle cell proliferation NIR nucleolus RNA-binding protein |
| title | NIR is a nucleolar RNA-binding protein that is involved in cell proliferation |
| title_full | NIR is a nucleolar RNA-binding protein that is involved in cell proliferation |
| title_fullStr | NIR is a nucleolar RNA-binding protein that is involved in cell proliferation |
| title_full_unstemmed | NIR is a nucleolar RNA-binding protein that is involved in cell proliferation |
| title_short | NIR is a nucleolar RNA-binding protein that is involved in cell proliferation |
| title_sort | nir is a nucleolar rna binding protein that is involved in cell proliferation |
| topic | cell cycle cell proliferation NIR nucleolus RNA-binding protein |
| url | http://www.doiserbia.nb.rs/img/doi/0354-4664/2013/0354-46641303929K.pdf |
| work_keys_str_mv | AT kangminkook nirisanucleolarrnabindingproteinthatisinvolvedincellproliferation AT hanseungjin nirisanucleolarrnabindingproteinthatisinvolvedincellproliferation |