Neuroprotective effects of taurine and 3-hydroxypyridine derivatives in the intracerebral hemorrhage model in rats
Introduction: At present, the problem of pharmacological correction of free radical processess emerges full-blown. The aim of the study is an experimental study of the neuroprotective effect of taurine and 3-hydroxypyridine derivatives. Materials and methods: The study was perform...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Belgorod National Research University
2019-09-01
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| Series: | Research Results in Pharmacology |
| Online Access: | https://rrpharmacology.pensoft.net/article/36988/download/pdf/ |
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| author | Natalia I. Nesterova Olesya V. Shcheblykina Pavel D. Kolesnichenko Arkady V. Nesterov Dmitry V. Shcheblykin Dmitry Yakovlev |
| author_facet | Natalia I. Nesterova Olesya V. Shcheblykina Pavel D. Kolesnichenko Arkady V. Nesterov Dmitry V. Shcheblykin Dmitry Yakovlev |
| author_sort | Natalia I. Nesterova |
| collection | DOAJ |
| description | Introduction: At present, the problem of pharmacological correction of free radical processess emerges full-blown. The aim of the study is an experimental study of the neuroprotective effect of taurine and 3-hydroxypyridine derivatives.
Materials and methods: The study was performed in Wistar rats. The neuroprotective effect of the substances was studied in the intracerebral hemorrhage model.
Results and discussion: The administration of the studied substances had a positive effect on the survival of the animals within the first day (50% of rats died in the control group, 30% – in the Mexidol- and Ethoxidol-treated groups, and 20% – in LKhT 3-17-treated group). Within the first day after the surgery, all rats with stroke had severe neurological disorders. However, by the 3rd day, the Ethoxidol- and LKhT 3-17-treated rats had a lower neurological deficit. By Day 14, all groups of animals treated with the test substances had a lower severity of post-stroke disorders than those in the control group, which was evident as a 1.5-time lower McGraw Stroke Index score. LKhT 3-17 substance showed the most pronounced neuroprotective effect.
Conclusions: The studied derivatives of taurine and 3-hydroxypyridine have a neuroprotective effect, which is manifested in the lower severity of neurological disorders,a more rapid reduction in the signs of neurodegeneration and accelerated hemorrhage processes. |
| first_indexed | 2024-03-09T09:29:35Z |
| format | Article |
| id | doaj.art-ffdfd14eb10b40f99fe84c0319d0b0f0 |
| institution | Directory Open Access Journal |
| issn | 2658-381X |
| language | English |
| last_indexed | 2024-03-09T09:29:35Z |
| publishDate | 2019-09-01 |
| publisher | Belgorod National Research University |
| record_format | Article |
| series | Research Results in Pharmacology |
| spelling | doaj.art-ffdfd14eb10b40f99fe84c0319d0b0f02023-12-02T05:02:43ZengBelgorod National Research UniversityResearch Results in Pharmacology2658-381X2019-09-0153879410.3897/rrpharmacology.5.3698836988Neuroprotective effects of taurine and 3-hydroxypyridine derivatives in the intracerebral hemorrhage model in ratsNatalia I. Nesterova0Olesya V. Shcheblykina1Pavel D. Kolesnichenko2Arkady V. Nesterov3Dmitry V. Shcheblykin4Dmitry Yakovlev5All-Russian Scientific Center for Safety of Biologically Active SubstancesAll-Russian Scientific Center for Safety of Biologically Active SubstancesAll-Russian Scientific Center for Safety of Biologically Active SubstancesAll-Russian Scientific Center for Safety of Biologically Active SubstancesAll-Russian Scientific Center for Safety of Biologically Active SubstancesAll-Russian Scientific Center for Safety of Biologically Active SubstancesIntroduction: At present, the problem of pharmacological correction of free radical processess emerges full-blown. The aim of the study is an experimental study of the neuroprotective effect of taurine and 3-hydroxypyridine derivatives. Materials and methods: The study was performed in Wistar rats. The neuroprotective effect of the substances was studied in the intracerebral hemorrhage model. Results and discussion: The administration of the studied substances had a positive effect on the survival of the animals within the first day (50% of rats died in the control group, 30% – in the Mexidol- and Ethoxidol-treated groups, and 20% – in LKhT 3-17-treated group). Within the first day after the surgery, all rats with stroke had severe neurological disorders. However, by the 3rd day, the Ethoxidol- and LKhT 3-17-treated rats had a lower neurological deficit. By Day 14, all groups of animals treated with the test substances had a lower severity of post-stroke disorders than those in the control group, which was evident as a 1.5-time lower McGraw Stroke Index score. LKhT 3-17 substance showed the most pronounced neuroprotective effect. Conclusions: The studied derivatives of taurine and 3-hydroxypyridine have a neuroprotective effect, which is manifested in the lower severity of neurological disorders,a more rapid reduction in the signs of neurodegeneration and accelerated hemorrhage processes.https://rrpharmacology.pensoft.net/article/36988/download/pdf/ |
| spellingShingle | Natalia I. Nesterova Olesya V. Shcheblykina Pavel D. Kolesnichenko Arkady V. Nesterov Dmitry V. Shcheblykin Dmitry Yakovlev Neuroprotective effects of taurine and 3-hydroxypyridine derivatives in the intracerebral hemorrhage model in rats Research Results in Pharmacology |
| title | Neuroprotective effects of taurine and 3-hydroxypyridine derivatives in the intracerebral hemorrhage model in rats |
| title_full | Neuroprotective effects of taurine and 3-hydroxypyridine derivatives in the intracerebral hemorrhage model in rats |
| title_fullStr | Neuroprotective effects of taurine and 3-hydroxypyridine derivatives in the intracerebral hemorrhage model in rats |
| title_full_unstemmed | Neuroprotective effects of taurine and 3-hydroxypyridine derivatives in the intracerebral hemorrhage model in rats |
| title_short | Neuroprotective effects of taurine and 3-hydroxypyridine derivatives in the intracerebral hemorrhage model in rats |
| title_sort | neuroprotective effects of taurine and 3 hydroxypyridine derivatives in the intracerebral hemorrhage model in rats |
| url | https://rrpharmacology.pensoft.net/article/36988/download/pdf/ |
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