Hyperphosphorylation of Tau Due to the Interference of Protein Phosphatase Methylesterase-1 Overexpression by MiR-125b-5p in Melatonin Receptor Knockout Mice

Hyperphosphorylation of Tau Due to the Interference of Protein Phosphatase Methylesterase-1 Overexpression by MiR-125b-5p in Melatonin Receptor Knockout Mice

Melatonin has been indicated to ameliorate tau hyperphosphorylation in the pathogenesis of tau diseases, but the role of melatonin-receptor signal transduction has not been clearly discovered. In this study, we found intensive tau hyperphosphorylation in melatonin receptor knockout mice. Bielschowsk...

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Bibliographic Details
Main Authors: Han Zhao, Lingyan Feng, Wei Zhong, Hongyan Zhen, Qingjia Chi, Xiang Wang
Format: Article
Language:English
Published: MDPI AG 2021-10-01
Series:International Journal of Molecular Sciences
Subjects:
melatonin
PME-1
mmu-miR-125b-5p
neurofibrillary tangles
protein phosphatase 2A
tau
Online Access:https://www.mdpi.com/1422-0067/22/21/11850

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