Formulation and characterization of gastroretentive discs containing famotidine
In this work a different type of formulation, as disc, containing a selected mucoadhesive polymer, fillers, and binders were investigated for their potential as a mucoadhesive gastroretentive delivery system to deliver famotidine in the stomach. Various types of hydrophilic diluents were evaluated f...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Instituto de Tecnologia do Paraná (Tecpar)
2011-04-01
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| Series: | Brazilian Archives of Biology and Technology |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132011000200010 |
| _version_ | 1819057918252679168 |
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| author | Jignyasha Amitkumar Raval Madhabhai M Patel |
| author_facet | Jignyasha Amitkumar Raval Madhabhai M Patel |
| author_sort | Jignyasha Amitkumar Raval |
| collection | DOAJ |
| description | In this work a different type of formulation, as disc, containing a selected mucoadhesive polymer, fillers, and binders were investigated for their potential as a mucoadhesive gastroretentive delivery system to deliver famotidine in the stomach. Various types of hydrophilic diluents were evaluated for their swelling and mucoadhesive property and one (polyvinylpyrrolidone, PVP) was selected to combine with the selected mucoadhesive polymer (polyethylene oxide, PEO). Discs with different ratios of PEO and PVP were prepared and evaluated for swelling, dissolution, and mucoadhesion. The swelling property of the discs increased as the concentration of PEO was increased and also did the mucoadhesion. These discs retained their integrity and adherence onto gastric mucosa for more than 10 h under in-vitro conditions. The PEO, in combination with PVP, yielded a non-disintegrating type mucoadhesive dosage form which was suitable for gastroretentive applications to achieve the desired release profile of the drug. |
| first_indexed | 2024-12-21T13:46:56Z |
| format | Article |
| id | doaj.art-ffe12e7f668f407f9a07bb81306bdc99 |
| institution | Directory Open Access Journal |
| issn | 1516-8913 1678-4324 |
| language | English |
| last_indexed | 2024-12-21T13:46:56Z |
| publishDate | 2011-04-01 |
| publisher | Instituto de Tecnologia do Paraná (Tecpar) |
| record_format | Article |
| series | Brazilian Archives of Biology and Technology |
| spelling | doaj.art-ffe12e7f668f407f9a07bb81306bdc992022-12-21T19:01:51ZengInstituto de Tecnologia do Paraná (Tecpar)Brazilian Archives of Biology and Technology1516-89131678-43242011-04-0154229330010.1590/S1516-89132011000200010Formulation and characterization of gastroretentive discs containing famotidineJignyasha Amitkumar RavalMadhabhai M PatelIn this work a different type of formulation, as disc, containing a selected mucoadhesive polymer, fillers, and binders were investigated for their potential as a mucoadhesive gastroretentive delivery system to deliver famotidine in the stomach. Various types of hydrophilic diluents were evaluated for their swelling and mucoadhesive property and one (polyvinylpyrrolidone, PVP) was selected to combine with the selected mucoadhesive polymer (polyethylene oxide, PEO). Discs with different ratios of PEO and PVP were prepared and evaluated for swelling, dissolution, and mucoadhesion. The swelling property of the discs increased as the concentration of PEO was increased and also did the mucoadhesion. These discs retained their integrity and adherence onto gastric mucosa for more than 10 h under in-vitro conditions. The PEO, in combination with PVP, yielded a non-disintegrating type mucoadhesive dosage form which was suitable for gastroretentive applications to achieve the desired release profile of the drug.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132011000200010mucoadhesiondiscsgastroretentivepolyethylene oxidepolyvinylpyrrolidone |
| spellingShingle | Jignyasha Amitkumar Raval Madhabhai M Patel Formulation and characterization of gastroretentive discs containing famotidine Brazilian Archives of Biology and Technology mucoadhesion discs gastroretentive polyethylene oxide polyvinylpyrrolidone |
| title | Formulation and characterization of gastroretentive discs containing famotidine |
| title_full | Formulation and characterization of gastroretentive discs containing famotidine |
| title_fullStr | Formulation and characterization of gastroretentive discs containing famotidine |
| title_full_unstemmed | Formulation and characterization of gastroretentive discs containing famotidine |
| title_short | Formulation and characterization of gastroretentive discs containing famotidine |
| title_sort | formulation and characterization of gastroretentive discs containing famotidine |
| topic | mucoadhesion discs gastroretentive polyethylene oxide polyvinylpyrrolidone |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S1516-89132011000200010 |
| work_keys_str_mv | AT jignyashaamitkumarraval formulationandcharacterizationofgastroretentivediscscontainingfamotidine AT madhabhaimpatel formulationandcharacterizationofgastroretentivediscscontainingfamotidine |