Norlobaridone Inhibits Quorum Sensing-Dependent Biofilm Formation and Some Virulence Factors in <i>Pseudomonas aeruginosa</i> by Disrupting Its Transcriptional Activator Protein LasR Dimerization

Norlobaridone Inhibits Quorum Sensing-Dependent Biofilm Formation and Some Virulence Factors in <i>Pseudomonas aeruginosa</i> by Disrupting Its Transcriptional Activator Protein LasR Dimerization

In the present study, norlobaridone (NBD) was isolated from <i>Parmotrema</i> and then evaluated as a new potent quorum sensing (QS) inhibitor against <i>Pseudomonas aeruginosa</i> biofilm development. This phenolic natural product was found to reduce <i>P. aeruginosa&l...

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Bibliographic Details
Main Authors:	Raya Soltane, Ahlam Alasiri, Mostafa N. Taha, Rehab H. Abd El-Aleam, Kawthar Saad Alghamdi, Mosad A. Ghareeb, Doaa El-Ghareeb Keshek, Susana M. Cardoso, Ahmed M. Sayed
Format:	Article
Language:	English
Published:	MDPI AG 2023-10-01
Series:	Biomolecules
Subjects:	quorum sensing <i>Pseudomonas aeruginosa</i> LuxR-type receptors assay LasR thermal shift assay MD simulation
Online Access:	https://www.mdpi.com/2218-273X/13/11/1573

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