Non-Metabolic Functions of PKM2 Contribute to Cervical Cancer Cell Proliferation Induced by the HPV16 E7 Oncoprotein

Non-Metabolic Functions of PKM2 Contribute to Cervical Cancer Cell Proliferation Induced by the HPV16 E7 Oncoprotein

Pyruvate kinase M2 (PKM2) mainly catalyzes glycolysis, but it also exerts non-glycolytic functions in several cancers. While it has been shown to interact with the human papillomavirus 16 (HPV16) E7 oncoprotein, the functional significance of PKM2 in HPV-associated cervical cancer has been elusive....

Full description

Bibliographic Details
Main Authors: Seoung-Ae Lee, Charles Ho, Madison Troxler, Chin-Yo Lin, Sang-Hyuk Chung
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Viruses
Subjects:
HPV16 E7
cervical cancer
PKM2
ML265
non-pyruvate kinase function
Online Access:https://www.mdpi.com/1999-4915/13/3/433

Similar Items

Similar Items