Prevalence of anti- beta2GPI antibodies and their isotypes in patients with renal diseases and clinical suspicion of antiphospholipid syndrome
Background: Antiphospholipid antibodies (aPL) are autoantibodies that are associated with a clinical state of hypercoagulability and diverse clinical manifestations collectively known as antiphospholipid syndrome (APS). Objectives: To investigate the prevalence of anti-beta2glycoproteinI-antibodies...
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| Format: | Article |
| Language: | English |
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Society of Diabetic Nephropathy Prevention
2013-07-01
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| Series: | Journal of Nephropathology |
| Subjects: | |
| Online Access: | https://nephropathol.com/PDF/jnp-2-181.pdf |
| _version_ | 1797827951791702016 |
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| author | Sabiha Anis Ejaz Ahmed Rana Muzaffar |
| author_facet | Sabiha Anis Ejaz Ahmed Rana Muzaffar |
| author_sort | Sabiha Anis |
| collection | DOAJ |
| description | Background: Antiphospholipid antibodies (aPL) are autoantibodies that are associated with a clinical state of hypercoagulability and diverse clinical manifestations collectively known as antiphospholipid syndrome (APS). Objectives: To investigate the prevalence of anti-beta2glycoproteinI-antibodies (anti-β2GPI) and their isotypes in patients with renal diseases and clinical suspicion of antiphospholipid syndrome (APS). Patients and Methods: This is a retrospective study in which we have analyzed the prevalence of anti-β2GPI and its isotypes in 170 patients on initial testing and in 29 patients repeated after 12 weeks for confirmation of APS. The clinical information was provided by the treating physicians or retrieved from the clinical records. The tests for anti-β2GPI screening and its isotypes (IgG, IgM and IgA) detection were assessed. Results: On initial samples, anti-β2GPI was positive in 118patients. IgA-β2GPI positivity (93; 79%) was significantly higher than IgM and IgG isotypes. Out of anti-β2GPI positive patients, clinical features in 95 patients were suggestive of APS or had SLE. Of these, IgA isotypes was found in 66% (P = 0.010), IgM in 31% (P = 0.033), and IgG in 11% (P = 0.033). On repeat testing, anti-β2GPI was persistently found In 22 patients with a continual predominance of IgA-anti-β2GPI over IgM and IgG isotypes (91% vs. 45.5% and 18% respectively). Conclusions: Our results show that IgA-anti-β2GPI antibodies are the most prevalent isotypes in patients with renal disease or on renal replacement therapy in our population. Thus inclusion of IgA-anti-β2GPI in the testing repertoire may increase the diagnostic sensitivity for APS in patients with renal diseases. |
| first_indexed | 2024-04-09T12:56:39Z |
| format | Article |
| id | doaj.art-ffe4fea3f3d246898f21ed2b3402afb3 |
| institution | Directory Open Access Journal |
| issn | 2251-8363 2251-8819 |
| language | English |
| last_indexed | 2024-04-09T12:56:39Z |
| publishDate | 2013-07-01 |
| publisher | Society of Diabetic Nephropathy Prevention |
| record_format | Article |
| series | Journal of Nephropathology |
| spelling | doaj.art-ffe4fea3f3d246898f21ed2b3402afb32023-05-13T11:43:00ZengSociety of Diabetic Nephropathy PreventionJournal of Nephropathology2251-83632251-88192013-07-012318118910.12860/JNP.2013.29JNP_20130930161421Prevalence of anti- beta2GPI antibodies and their isotypes in patients with renal diseases and clinical suspicion of antiphospholipid syndromeSabiha Anis0Ejaz Ahmed1Rana Muzaffar2Department of Molecular Diagnostics and Immunology, Sindh Institute of Urology and Transplantation, Karachi, Pakistan.Department of Nephrology, Sindh Institute of Urology and Transplantation, Karachi, Pakistan.Department of Molecular Diagnostics and Immunology, Sindh Institute of Urology and Transplantation, Karachi, Pakistan.Background: Antiphospholipid antibodies (aPL) are autoantibodies that are associated with a clinical state of hypercoagulability and diverse clinical manifestations collectively known as antiphospholipid syndrome (APS). Objectives: To investigate the prevalence of anti-beta2glycoproteinI-antibodies (anti-β2GPI) and their isotypes in patients with renal diseases and clinical suspicion of antiphospholipid syndrome (APS). Patients and Methods: This is a retrospective study in which we have analyzed the prevalence of anti-β2GPI and its isotypes in 170 patients on initial testing and in 29 patients repeated after 12 weeks for confirmation of APS. The clinical information was provided by the treating physicians or retrieved from the clinical records. The tests for anti-β2GPI screening and its isotypes (IgG, IgM and IgA) detection were assessed. Results: On initial samples, anti-β2GPI was positive in 118patients. IgA-β2GPI positivity (93; 79%) was significantly higher than IgM and IgG isotypes. Out of anti-β2GPI positive patients, clinical features in 95 patients were suggestive of APS or had SLE. Of these, IgA isotypes was found in 66% (P = 0.010), IgM in 31% (P = 0.033), and IgG in 11% (P = 0.033). On repeat testing, anti-β2GPI was persistently found In 22 patients with a continual predominance of IgA-anti-β2GPI over IgM and IgG isotypes (91% vs. 45.5% and 18% respectively). Conclusions: Our results show that IgA-anti-β2GPI antibodies are the most prevalent isotypes in patients with renal disease or on renal replacement therapy in our population. Thus inclusion of IgA-anti-β2GPI in the testing repertoire may increase the diagnostic sensitivity for APS in patients with renal diseases.https://nephropathol.com/PDF/jnp-2-181.pdfiga-anti-β2gpianti-β2-glycoproteini antibodiesantiphospholipid syndromearterio-venous-fistula-formation failuresrenal apsrenal transplant recipientssystemic lupus erythematosus |
| spellingShingle | Sabiha Anis Ejaz Ahmed Rana Muzaffar Prevalence of anti- beta2GPI antibodies and their isotypes in patients with renal diseases and clinical suspicion of antiphospholipid syndrome Journal of Nephropathology iga-anti-β2gpi anti-β2-glycoproteini antibodies antiphospholipid syndrome arterio-venous-fistula-formation failures renal aps renal transplant recipients systemic lupus erythematosus |
| title | Prevalence of anti- beta2GPI antibodies and their isotypes in patients with renal diseases and clinical suspicion of antiphospholipid syndrome |
| title_full | Prevalence of anti- beta2GPI antibodies and their isotypes in patients with renal diseases and clinical suspicion of antiphospholipid syndrome |
| title_fullStr | Prevalence of anti- beta2GPI antibodies and their isotypes in patients with renal diseases and clinical suspicion of antiphospholipid syndrome |
| title_full_unstemmed | Prevalence of anti- beta2GPI antibodies and their isotypes in patients with renal diseases and clinical suspicion of antiphospholipid syndrome |
| title_short | Prevalence of anti- beta2GPI antibodies and their isotypes in patients with renal diseases and clinical suspicion of antiphospholipid syndrome |
| title_sort | prevalence of anti beta2gpi antibodies and their isotypes in patients with renal diseases and clinical suspicion of antiphospholipid syndrome |
| topic | iga-anti-β2gpi anti-β2-glycoproteini antibodies antiphospholipid syndrome arterio-venous-fistula-formation failures renal aps renal transplant recipients systemic lupus erythematosus |
| url | https://nephropathol.com/PDF/jnp-2-181.pdf |
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