Effectiveness and Safety of Short-term Regimen for Multidrug-resistant Tuberculosis Treatment: A Systematic Review of Cohort Studies
This systematic review explores the effectiveness and safety of a short-term regimen (STR) in treating multidrug-resistant tuberculosis (MDR-TB). We use several cohort studies which were searched using standardized Preferred Reporting Items for Systematic Reviews and Meta-Analyses. The keywords were...
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| Format: | Article |
| Language: | English |
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Oman Medical Specialty Board
2022-01-01
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| Series: | Oman Medical Journal |
| Subjects: | |
| Online Access: | https://omjournal.org/articleDetails.aspx?coType=1&aId=3064 |
| _version_ | 1819279089799790592 |
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| author | Putu Nandika Mahardani Dyah Kanya Wati Azriel Siloam Ni Putu Ayu Savitri Arya Krisna Manggala |
| author_facet | Putu Nandika Mahardani Dyah Kanya Wati Azriel Siloam Ni Putu Ayu Savitri Arya Krisna Manggala |
| author_sort | Putu Nandika Mahardani |
| collection | DOAJ |
| description | This systematic review explores the effectiveness and safety of a short-term regimen (STR) in treating multidrug-resistant tuberculosis (MDR-TB). We use several cohort studies which were searched using standardized Preferred Reporting Items for Systematic Reviews and Meta-Analyses. The keywords were used based on problem, intervention, comparison, and outcome consisted of MDR-TB and STR. Seven cohort studies were selected from 314 studies. The result showed that STR has better therapeutic efficacy and shorter duration than the 2011 World Health Organization regimen for MDR-TB with success rates above 50% in respective studies. The most effective regimen was kanamycin-high-dose isoniazid-clofazimine-ethambutol-prothionamide-pyrazinamide-gatifloxacin in the intensive phase for four months and clofazimine-ethambutol-pyrazinamide-gatifloxacin-prothionamide in the continuation phase for eight months. Gastrointestinal problems, ototoxicity, dysglycemia, and liver problems were the most reported side effects. STR provides good effectiveness in MDR-TB treatment in terms of treatment success rate and short therapy duration. |
| first_indexed | 2024-12-24T00:22:22Z |
| format | Article |
| id | doaj.art-ffe6a1ae8f17449596cdbbbf8b5491b6 |
| institution | Directory Open Access Journal |
| issn | 1999-768X 2070-5204 |
| language | English |
| last_indexed | 2024-12-24T00:22:22Z |
| publishDate | 2022-01-01 |
| publisher | Oman Medical Specialty Board |
| record_format | Article |
| series | Oman Medical Journal |
| spelling | doaj.art-ffe6a1ae8f17449596cdbbbf8b5491b62022-12-21T17:24:33ZengOman Medical Specialty BoardOman Medical Journal1999-768X2070-52042022-01-01371e337e33710.5001/omj.2021.64Effectiveness and Safety of Short-term Regimen for Multidrug-resistant Tuberculosis Treatment: A Systematic Review of Cohort StudiesPutu Nandika Mahardani0Dyah Kanya Wati1Azriel Siloam2Ni Putu Ayu Savitri3Arya Krisna Manggala4School of Medicine, Faculty of Medicine, Udayana University, Bali, IndonesiaPediatric Emergency and Intensive Care Sanglah Public Hospital, Faculty of Medicine, Udayana University, Bali, IndonesiaSchool of Medicine, Faculty of Medicine, Udayana University, Bali, IndonesiaSchool of Medicine, Faculty of Medicine, Udayana University, Bali, IndonesiaSchool of Medicine, Faculty of Medicine, Udayana University, Bali, IndonesiaThis systematic review explores the effectiveness and safety of a short-term regimen (STR) in treating multidrug-resistant tuberculosis (MDR-TB). We use several cohort studies which were searched using standardized Preferred Reporting Items for Systematic Reviews and Meta-Analyses. The keywords were used based on problem, intervention, comparison, and outcome consisted of MDR-TB and STR. Seven cohort studies were selected from 314 studies. The result showed that STR has better therapeutic efficacy and shorter duration than the 2011 World Health Organization regimen for MDR-TB with success rates above 50% in respective studies. The most effective regimen was kanamycin-high-dose isoniazid-clofazimine-ethambutol-prothionamide-pyrazinamide-gatifloxacin in the intensive phase for four months and clofazimine-ethambutol-pyrazinamide-gatifloxacin-prothionamide in the continuation phase for eight months. Gastrointestinal problems, ototoxicity, dysglycemia, and liver problems were the most reported side effects. STR provides good effectiveness in MDR-TB treatment in terms of treatment success rate and short therapy duration.https://omjournal.org/articleDetails.aspx?coType=1&aId=3064tuberculosismultidrug-resistantduration of therapysafety |
| spellingShingle | Putu Nandika Mahardani Dyah Kanya Wati Azriel Siloam Ni Putu Ayu Savitri Arya Krisna Manggala Effectiveness and Safety of Short-term Regimen for Multidrug-resistant Tuberculosis Treatment: A Systematic Review of Cohort Studies Oman Medical Journal tuberculosis multidrug-resistant duration of therapy safety |
| title | Effectiveness and Safety of Short-term Regimen for Multidrug-resistant Tuberculosis Treatment: A Systematic Review of Cohort Studies |
| title_full | Effectiveness and Safety of Short-term Regimen for Multidrug-resistant Tuberculosis Treatment: A Systematic Review of Cohort Studies |
| title_fullStr | Effectiveness and Safety of Short-term Regimen for Multidrug-resistant Tuberculosis Treatment: A Systematic Review of Cohort Studies |
| title_full_unstemmed | Effectiveness and Safety of Short-term Regimen for Multidrug-resistant Tuberculosis Treatment: A Systematic Review of Cohort Studies |
| title_short | Effectiveness and Safety of Short-term Regimen for Multidrug-resistant Tuberculosis Treatment: A Systematic Review of Cohort Studies |
| title_sort | effectiveness and safety of short term regimen for multidrug resistant tuberculosis treatment a systematic review of cohort studies |
| topic | tuberculosis multidrug-resistant duration of therapy safety |
| url | https://omjournal.org/articleDetails.aspx?coType=1&aId=3064 |
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