Impact of HCV viremia on HBV biomarkers in patients coinfected with HBV and HCV
Abstract Backgrounds: Hepatitis B virus (HBV) biomarkers reflect the status of HBV infection; however, their role in patients with chronic hepatitis B and C (HBV/HCV) coinfection remains unknown. This study evaluated the characteristics of HBV biomarkers in patients with chronic HBV/HCV coinfection....
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
BMC
2022-04-01
|
| Series: | BMC Infectious Diseases |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12879-022-07326-1 |
| _version_ | 1819209954125414400 |
|---|---|
| author | Chih-Wei Tseng Wen-Chun Liu Chi-Yi Chen Ting-Tsung Chang Kuo-Chih Tseng |
| author_facet | Chih-Wei Tseng Wen-Chun Liu Chi-Yi Chen Ting-Tsung Chang Kuo-Chih Tseng |
| author_sort | Chih-Wei Tseng |
| collection | DOAJ |
| description | Abstract Backgrounds: Hepatitis B virus (HBV) biomarkers reflect the status of HBV infection; however, their role in patients with chronic hepatitis B and C (HBV/HCV) coinfection remains unknown. This study evaluated the characteristics of HBV biomarkers in patients with chronic HBV/HCV coinfection. Methods One hundred untreated HBV/HCV coinfected patients were enrolled. Active viral infection was defined as viral load above 2000 U/L and 15 U/L for HBV and HCV, respectively. Blood samples were analyzed for HBV biomarkers, including hepatitis B surface antigen (HBsAg), hepatitis B core-related antigen (HBcrAg), HBV DNA, and HBV pregenomic RNA (HBV pgRNA). The impact of HCV viremia was also studied. Results A total of 15 patients were HBV-inactive/HCV-inactive, 63 patients were HBV-inactive/HCV-active, 14 patients were HBV-active/HCV-inactive and 8 patients were HBV-active/HCV-active. A total of 71 (71%) patients were active HCV and 22 (22%) were active HBV. HBsAg, HBcrAg, and HBV DNA correlated with each other (P < 0.001). HBV pgRNA displayed no correlations with HBV DNA, HBsAg, or HBcrAg. Patients with HCV viremia had significantly lower HBV DNA, HBsAg, and HBcrAg levels as well as higher HBV pgRNA levels and lower HBV DNA:pgRNA ratio than those without viremia (HBV DNA, P < 0.001; HBsAg, P = 0.015; HBcrAg, P = 0.006; HBV pgRNA, P = 0.073; and HBV DNA:pgRNA ratio, P < 0.001). Conclusions In patients coinfected with HBV and HCV, HBsAg, HBcrAg, and HBV DNA significantly correlated with each other. HBV and HCV coinfected patients with HCV viremia have lower HBV DNA, HBsAg, HBcrAg, and HBV DNA:pgRNA ratio as well as higher HBV pgRNA levels. |
| first_indexed | 2024-12-23T06:03:29Z |
| format | Article |
| id | doaj.art-ffe6d6a5f4b545de91071be512b18d0b |
| institution | Directory Open Access Journal |
| issn | 1471-2334 |
| language | English |
| last_indexed | 2024-12-23T06:03:29Z |
| publishDate | 2022-04-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Infectious Diseases |
| spelling | doaj.art-ffe6d6a5f4b545de91071be512b18d0b2022-12-21T17:57:38ZengBMCBMC Infectious Diseases1471-23342022-04-012211910.1186/s12879-022-07326-1Impact of HCV viremia on HBV biomarkers in patients coinfected with HBV and HCVChih-Wei Tseng0Wen-Chun Liu1Chi-Yi Chen2Ting-Tsung Chang3Kuo-Chih Tseng4Department of Internal Medicine, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical FoundationDepartment of Internal Medicine, National Cheng Kung University HospitalDepartment of Internal Medicine, Ditmanson Medical Foundation Chia-Yi Christian HospitalDepartment of Internal Medicine, National Cheng Kung University HospitalDepartment of Internal Medicine, Dalin Tzu Chi Hospital, Buddhist Tzu Chi Medical FoundationAbstract Backgrounds: Hepatitis B virus (HBV) biomarkers reflect the status of HBV infection; however, their role in patients with chronic hepatitis B and C (HBV/HCV) coinfection remains unknown. This study evaluated the characteristics of HBV biomarkers in patients with chronic HBV/HCV coinfection. Methods One hundred untreated HBV/HCV coinfected patients were enrolled. Active viral infection was defined as viral load above 2000 U/L and 15 U/L for HBV and HCV, respectively. Blood samples were analyzed for HBV biomarkers, including hepatitis B surface antigen (HBsAg), hepatitis B core-related antigen (HBcrAg), HBV DNA, and HBV pregenomic RNA (HBV pgRNA). The impact of HCV viremia was also studied. Results A total of 15 patients were HBV-inactive/HCV-inactive, 63 patients were HBV-inactive/HCV-active, 14 patients were HBV-active/HCV-inactive and 8 patients were HBV-active/HCV-active. A total of 71 (71%) patients were active HCV and 22 (22%) were active HBV. HBsAg, HBcrAg, and HBV DNA correlated with each other (P < 0.001). HBV pgRNA displayed no correlations with HBV DNA, HBsAg, or HBcrAg. Patients with HCV viremia had significantly lower HBV DNA, HBsAg, and HBcrAg levels as well as higher HBV pgRNA levels and lower HBV DNA:pgRNA ratio than those without viremia (HBV DNA, P < 0.001; HBsAg, P = 0.015; HBcrAg, P = 0.006; HBV pgRNA, P = 0.073; and HBV DNA:pgRNA ratio, P < 0.001). Conclusions In patients coinfected with HBV and HCV, HBsAg, HBcrAg, and HBV DNA significantly correlated with each other. HBV and HCV coinfected patients with HCV viremia have lower HBV DNA, HBsAg, HBcrAg, and HBV DNA:pgRNA ratio as well as higher HBV pgRNA levels.https://doi.org/10.1186/s12879-022-07326-1Hepatitis B surface antigenHepatitis B core-related antigenHBV pregenomic RNAHBV/HCV coinfection |
| spellingShingle | Chih-Wei Tseng Wen-Chun Liu Chi-Yi Chen Ting-Tsung Chang Kuo-Chih Tseng Impact of HCV viremia on HBV biomarkers in patients coinfected with HBV and HCV BMC Infectious Diseases Hepatitis B surface antigen Hepatitis B core-related antigen HBV pregenomic RNA HBV/HCV coinfection |
| title | Impact of HCV viremia on HBV biomarkers in patients coinfected with HBV and HCV |
| title_full | Impact of HCV viremia on HBV biomarkers in patients coinfected with HBV and HCV |
| title_fullStr | Impact of HCV viremia on HBV biomarkers in patients coinfected with HBV and HCV |
| title_full_unstemmed | Impact of HCV viremia on HBV biomarkers in patients coinfected with HBV and HCV |
| title_short | Impact of HCV viremia on HBV biomarkers in patients coinfected with HBV and HCV |
| title_sort | impact of hcv viremia on hbv biomarkers in patients coinfected with hbv and hcv |
| topic | Hepatitis B surface antigen Hepatitis B core-related antigen HBV pregenomic RNA HBV/HCV coinfection |
| url | https://doi.org/10.1186/s12879-022-07326-1 |
| work_keys_str_mv | AT chihweitseng impactofhcvviremiaonhbvbiomarkersinpatientscoinfectedwithhbvandhcv AT wenchunliu impactofhcvviremiaonhbvbiomarkersinpatientscoinfectedwithhbvandhcv AT chiyichen impactofhcvviremiaonhbvbiomarkersinpatientscoinfectedwithhbvandhcv AT tingtsungchang impactofhcvviremiaonhbvbiomarkersinpatientscoinfectedwithhbvandhcv AT kuochihtseng impactofhcvviremiaonhbvbiomarkersinpatientscoinfectedwithhbvandhcv |