Synthesis, antitumour and antioxidant activities of novel α,β-unsaturated ketones and related heterocyclic analogues: EGFR inhibition and molecular modelling study

Synthesis, antitumour and antioxidant activities of novel α,β-unsaturated ketones and related heterocyclic analogues: EGFR inhibition and molecular modelling study

New α,β-unsaturated ketones 4a,b; 5a–c; and 6a,b; as well as 4-H pyran 7; pyrazoline 8a,b; isoxazoline 9; pyridine 10–11; and quinoline-4-carboxylic acid 12a,b derivatives were synthesized and evaluated for in vitro antitumour activity against HepG2, MCF-7, HeLa, and PC-3 cancer cell lines. Antioxid...

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Bibliographic Details
Main Authors: Walaa M. El-Husseiny, Magda A.-A. El-Sayed, Naglaa I. Abdel-Aziz, Adel S. El-Azab, Esam R. Ahmed, Alaa A.-M. Abdel-Aziz
Format: Article
Language:English
Published: Taylor & Francis Group 2018-01-01
Series:Journal of Enzyme Inhibition and Medicinal Chemistry
Subjects:
α,β-Unsaturated ketone
antitumour activity
antioxidant effect
EGFR inhibition
molecular docking
Online Access:http://dx.doi.org/10.1080/14756366.2018.1434519

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