Toward Long-Term-Dispersible, Metal-Free Single-Chain Nanoparticles
We report herein on a new platform for synthesizing stable, inert, and dispersible metal-free single-chain nanoparticles (SCNPs) via intramolecular metal-traceless azide–alkyne click chemistry. It is well known that SCNPs synthesized via Cu(I)-catalyzed azide–alkyne cycloaddition (CuAAC) often exper...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-04-01
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| Series: | Nanomaterials |
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| Online Access: | https://www.mdpi.com/2079-4991/13/8/1394 |
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| author | Agustín Blázquez-Martín Ainara Ruiz-Bardillo Ester Verde-Sesto Amaia Iturrospe Arantxa Arbe José A. Pomposo |
| author_facet | Agustín Blázquez-Martín Ainara Ruiz-Bardillo Ester Verde-Sesto Amaia Iturrospe Arantxa Arbe José A. Pomposo |
| author_sort | Agustín Blázquez-Martín |
| collection | DOAJ |
| description | We report herein on a new platform for synthesizing stable, inert, and dispersible metal-free single-chain nanoparticles (SCNPs) via intramolecular metal-traceless azide–alkyne click chemistry. It is well known that SCNPs synthesized via Cu(I)-catalyzed azide–alkyne cycloaddition (CuAAC) often experience metal-induced aggregation issues during storage. Moreover, the presence of metal traces limits its use in a number of potential applications. To address these problems, we selected a bifunctional cross-linker molecule, <i>sym</i>-dibenzo-1,5-cyclooctadiene-3,7-diyne (DIBOD). DIBOD has two highly strained alkyne bonds that allow for the synthesis of metal-free SCNPs. We demonstrate the utility of this new approach by synthesizing metal-free polystyrene (PS)-SCNPs without significant aggregation issues during storage, as demonstrated by small-angle X-ray scattering (SAXS) experiments. Notably, this method paves the way for the synthesis of long-term-dispersible, metal-free SCNPs from potentially any polymer precursor decorated with azide functional groups. |
| first_indexed | 2024-03-11T04:40:55Z |
| format | Article |
| id | doaj.art-ffe983d8792549418989b2fbbf6d3170 |
| institution | Directory Open Access Journal |
| issn | 2079-4991 |
| language | English |
| last_indexed | 2024-03-11T04:40:55Z |
| publishDate | 2023-04-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nanomaterials |
| spelling | doaj.art-ffe983d8792549418989b2fbbf6d31702023-11-17T20:43:51ZengMDPI AGNanomaterials2079-49912023-04-01138139410.3390/nano13081394Toward Long-Term-Dispersible, Metal-Free Single-Chain NanoparticlesAgustín Blázquez-Martín0Ainara Ruiz-Bardillo1Ester Verde-Sesto2Amaia Iturrospe3Arantxa Arbe4José A. Pomposo5Centro de Física de Materiales (CSIC, UPV/EHU)-Materials Physics Center (MPC), 20018 Donostia-San Sebastián, SpainCentro de Física de Materiales (CSIC, UPV/EHU)-Materials Physics Center (MPC), 20018 Donostia-San Sebastián, SpainCentro de Física de Materiales (CSIC, UPV/EHU)-Materials Physics Center (MPC), 20018 Donostia-San Sebastián, SpainCentro de Física de Materiales (CSIC, UPV/EHU)-Materials Physics Center (MPC), 20018 Donostia-San Sebastián, SpainCentro de Física de Materiales (CSIC, UPV/EHU)-Materials Physics Center (MPC), 20018 Donostia-San Sebastián, SpainCentro de Física de Materiales (CSIC, UPV/EHU)-Materials Physics Center (MPC), 20018 Donostia-San Sebastián, SpainWe report herein on a new platform for synthesizing stable, inert, and dispersible metal-free single-chain nanoparticles (SCNPs) via intramolecular metal-traceless azide–alkyne click chemistry. It is well known that SCNPs synthesized via Cu(I)-catalyzed azide–alkyne cycloaddition (CuAAC) often experience metal-induced aggregation issues during storage. Moreover, the presence of metal traces limits its use in a number of potential applications. To address these problems, we selected a bifunctional cross-linker molecule, <i>sym</i>-dibenzo-1,5-cyclooctadiene-3,7-diyne (DIBOD). DIBOD has two highly strained alkyne bonds that allow for the synthesis of metal-free SCNPs. We demonstrate the utility of this new approach by synthesizing metal-free polystyrene (PS)-SCNPs without significant aggregation issues during storage, as demonstrated by small-angle X-ray scattering (SAXS) experiments. Notably, this method paves the way for the synthesis of long-term-dispersible, metal-free SCNPs from potentially any polymer precursor decorated with azide functional groups.https://www.mdpi.com/2079-4991/13/8/1394single-chain nanoparticles (SCNPs)metal-free click chemistryintramolecular cross-linking<i>sym</i>-dibenzo-1,5-cyclooctadiene-3,7-diyne (DIBOD)strain-promoted azide−alkyne cycloaddition (SPAAC) |
| spellingShingle | Agustín Blázquez-Martín Ainara Ruiz-Bardillo Ester Verde-Sesto Amaia Iturrospe Arantxa Arbe José A. Pomposo Toward Long-Term-Dispersible, Metal-Free Single-Chain Nanoparticles Nanomaterials single-chain nanoparticles (SCNPs) metal-free click chemistry intramolecular cross-linking <i>sym</i>-dibenzo-1,5-cyclooctadiene-3,7-diyne (DIBOD) strain-promoted azide−alkyne cycloaddition (SPAAC) |
| title | Toward Long-Term-Dispersible, Metal-Free Single-Chain Nanoparticles |
| title_full | Toward Long-Term-Dispersible, Metal-Free Single-Chain Nanoparticles |
| title_fullStr | Toward Long-Term-Dispersible, Metal-Free Single-Chain Nanoparticles |
| title_full_unstemmed | Toward Long-Term-Dispersible, Metal-Free Single-Chain Nanoparticles |
| title_short | Toward Long-Term-Dispersible, Metal-Free Single-Chain Nanoparticles |
| title_sort | toward long term dispersible metal free single chain nanoparticles |
| topic | single-chain nanoparticles (SCNPs) metal-free click chemistry intramolecular cross-linking <i>sym</i>-dibenzo-1,5-cyclooctadiene-3,7-diyne (DIBOD) strain-promoted azide−alkyne cycloaddition (SPAAC) |
| url | https://www.mdpi.com/2079-4991/13/8/1394 |
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