Clinical application of spectral CT perfusion scanning in evaluating the blood supply source of portal vein tumor thrombus in hepatocellular carcinoma
PurposeTo evaluate the characteristic of blood supply of liver portal vein tumor thrombus (PVTT) using perfusion indexes and spectral parameters.MethodsBetween July 2020 and December 2022, the study enrolled 25 liver cancer patients completed with PVTT (male=20, female=5; age 41-74 years (59.48 ± 9....
| Main Authors: | , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Frontiers Media S.A.
2024-01-01
|
| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2023.1348679/full |
| _version_ | 1797353641922789376 |
|---|---|
| author | Chunhan Pan Feng Dai Liuli Sheng Kang Li Wei Qiao Zheng Kang Xiuming Zhang |
| author_facet | Chunhan Pan Feng Dai Liuli Sheng Kang Li Wei Qiao Zheng Kang Xiuming Zhang |
| author_sort | Chunhan Pan |
| collection | DOAJ |
| description | PurposeTo evaluate the characteristic of blood supply of liver portal vein tumor thrombus (PVTT) using perfusion indexes and spectral parameters.MethodsBetween July 2020 and December 2022, the study enrolled 25 liver cancer patients completed with PVTT (male=20, female=5; age 41-74 years (59.48 ± 9.12)) from the Interventional Department of Jiangsu Cancer Hospital. There were 11 cases of type III PVTT, 12 of type II PVTT, and 2 of type I PVTT (Cheng’s classification). All patients underwent spectral perfusion scans through dual-layer spectral detector computed tomography. The PVTTs were divided into proximal and distal groups based on the distance between the tumor thrombus and the main portal vein. The perfusion analysis was performed on the 120-kVp conventional images to generate hepatic perfusion index (HPI). The spectral based images (SBIs) during the artery and venous peak phases were extracted from the perfusion data. The iodine map and 40&100-keV virtual monoenergetic image (VMI) were generated from SBI data. HPI, iodine concentration (IC), CT value at 40 and 100-keV, and spectral slope (40-100keV) of the primary lesion, proximal and distal PVTT, and liver parenchyma were measured and compared. The correlation between the primary lesion and proximal and distal PVTT was analyzed.ResultsThe IC and spectral slope during the arterial and venous peak phases and HPI of the primary lesion, proximal PVTT, and distal PVTT were highly correlated (P<0.001). The differences between the IC and spectral slope during the arterial and venous peak phases and HPI of the primary lesion, proximal PVTT were statistically significant (P<0.001). The differences between the IC during venous peak phase and HPI of primary lesion, distal PVTT were statistically significant (P<0.001), and there was no statistically significant difference in arterial phase IC, arterial and venous phase spectral slopes.ConclusionThe IC, slope, and HPI of the distal and proximal PVTT were highly correlated with the primary lesion, indicating that PVTT was similar to the primary lesion in the liver that they were both mainly supplied by the hepatic artery. However, there was still significant heterogeneity between the proximal PVTT and the primary lesion, while the difference in the distal PVTT was relatively small. |
| first_indexed | 2024-03-08T13:33:59Z |
| format | Article |
| id | doaj.art-ffeb95a95319457681ddebd73d744840 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-03-08T13:33:59Z |
| publishDate | 2024-01-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-ffeb95a95319457681ddebd73d7448402024-01-17T04:37:06ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2024-01-011310.3389/fonc.2023.13486791348679Clinical application of spectral CT perfusion scanning in evaluating the blood supply source of portal vein tumor thrombus in hepatocellular carcinomaChunhan Pan0Feng Dai1Liuli Sheng2Kang Li3Wei Qiao4Zheng Kang5Xiuming Zhang6Department of Radiology, The Affiliated Cancer Hospital of Nanjing Medical University, Jiangsu Cancer Hospital and Jiangsu Institute of Cancer Research, Nanjing, ChinaDepartment of Intervention, The Second Hospital of Nanjing, Nanjing, ChinaDepartment of Radiology, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research and The Affiliated Cancer Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Radiology, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research and The Affiliated Cancer Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Radiology, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research and The Affiliated Cancer Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Radiology, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research and The Affiliated Cancer Hospital of Nanjing Medical University, Nanjing, ChinaDepartment of Radiology, Jiangsu Cancer Hospital, Jiangsu Institute of Cancer Research and The Affiliated Cancer Hospital of Nanjing Medical University, Nanjing, ChinaPurposeTo evaluate the characteristic of blood supply of liver portal vein tumor thrombus (PVTT) using perfusion indexes and spectral parameters.MethodsBetween July 2020 and December 2022, the study enrolled 25 liver cancer patients completed with PVTT (male=20, female=5; age 41-74 years (59.48 ± 9.12)) from the Interventional Department of Jiangsu Cancer Hospital. There were 11 cases of type III PVTT, 12 of type II PVTT, and 2 of type I PVTT (Cheng’s classification). All patients underwent spectral perfusion scans through dual-layer spectral detector computed tomography. The PVTTs were divided into proximal and distal groups based on the distance between the tumor thrombus and the main portal vein. The perfusion analysis was performed on the 120-kVp conventional images to generate hepatic perfusion index (HPI). The spectral based images (SBIs) during the artery and venous peak phases were extracted from the perfusion data. The iodine map and 40&100-keV virtual monoenergetic image (VMI) were generated from SBI data. HPI, iodine concentration (IC), CT value at 40 and 100-keV, and spectral slope (40-100keV) of the primary lesion, proximal and distal PVTT, and liver parenchyma were measured and compared. The correlation between the primary lesion and proximal and distal PVTT was analyzed.ResultsThe IC and spectral slope during the arterial and venous peak phases and HPI of the primary lesion, proximal PVTT, and distal PVTT were highly correlated (P<0.001). The differences between the IC and spectral slope during the arterial and venous peak phases and HPI of the primary lesion, proximal PVTT were statistically significant (P<0.001). The differences between the IC during venous peak phase and HPI of primary lesion, distal PVTT were statistically significant (P<0.001), and there was no statistically significant difference in arterial phase IC, arterial and venous phase spectral slopes.ConclusionThe IC, slope, and HPI of the distal and proximal PVTT were highly correlated with the primary lesion, indicating that PVTT was similar to the primary lesion in the liver that they were both mainly supplied by the hepatic artery. However, there was still significant heterogeneity between the proximal PVTT and the primary lesion, while the difference in the distal PVTT was relatively small.https://www.frontiersin.org/articles/10.3389/fonc.2023.1348679/fullPVTThepatocellular carcinoma (HCC)spectral computed tomographyspectral based imagevirtual monoenergetic images |
| spellingShingle | Chunhan Pan Feng Dai Liuli Sheng Kang Li Wei Qiao Zheng Kang Xiuming Zhang Clinical application of spectral CT perfusion scanning in evaluating the blood supply source of portal vein tumor thrombus in hepatocellular carcinoma Frontiers in Oncology PVTT hepatocellular carcinoma (HCC) spectral computed tomography spectral based image virtual monoenergetic images |
| title | Clinical application of spectral CT perfusion scanning in evaluating the blood supply source of portal vein tumor thrombus in hepatocellular carcinoma |
| title_full | Clinical application of spectral CT perfusion scanning in evaluating the blood supply source of portal vein tumor thrombus in hepatocellular carcinoma |
| title_fullStr | Clinical application of spectral CT perfusion scanning in evaluating the blood supply source of portal vein tumor thrombus in hepatocellular carcinoma |
| title_full_unstemmed | Clinical application of spectral CT perfusion scanning in evaluating the blood supply source of portal vein tumor thrombus in hepatocellular carcinoma |
| title_short | Clinical application of spectral CT perfusion scanning in evaluating the blood supply source of portal vein tumor thrombus in hepatocellular carcinoma |
| title_sort | clinical application of spectral ct perfusion scanning in evaluating the blood supply source of portal vein tumor thrombus in hepatocellular carcinoma |
| topic | PVTT hepatocellular carcinoma (HCC) spectral computed tomography spectral based image virtual monoenergetic images |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2023.1348679/full |
| work_keys_str_mv | AT chunhanpan clinicalapplicationofspectralctperfusionscanninginevaluatingthebloodsupplysourceofportalveintumorthrombusinhepatocellularcarcinoma AT fengdai clinicalapplicationofspectralctperfusionscanninginevaluatingthebloodsupplysourceofportalveintumorthrombusinhepatocellularcarcinoma AT liulisheng clinicalapplicationofspectralctperfusionscanninginevaluatingthebloodsupplysourceofportalveintumorthrombusinhepatocellularcarcinoma AT kangli clinicalapplicationofspectralctperfusionscanninginevaluatingthebloodsupplysourceofportalveintumorthrombusinhepatocellularcarcinoma AT weiqiao clinicalapplicationofspectralctperfusionscanninginevaluatingthebloodsupplysourceofportalveintumorthrombusinhepatocellularcarcinoma AT zhengkang clinicalapplicationofspectralctperfusionscanninginevaluatingthebloodsupplysourceofportalveintumorthrombusinhepatocellularcarcinoma AT xiumingzhang clinicalapplicationofspectralctperfusionscanninginevaluatingthebloodsupplysourceofportalveintumorthrombusinhepatocellularcarcinoma |