Lipid and lipoprotein concentrations during pregnancy and associations with ethnicity
Abstract Background To describe ethnic differences in concentrations of lipids and lipoproteins, and their changes, during pregnancy to postpartum. Methods This was a population-based cohort study conducted in primary antenatal care in Norway. The participants (n = 806) were healthy, pregnant women,...
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| Format: | Article |
| Language: | English |
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BMC
2022-03-01
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| Series: | BMC Pregnancy and Childbirth |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12884-022-04524-2 |
| _version_ | 1811335593227976704 |
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| author | Christin W. Waage Ibrahim Mdala Hein Stigum Anne Karen Jenum Kåre I. Birkeland Nilam Shakeel Trond M. Michelsen Kåre R. Richardsen Line Sletner |
| author_facet | Christin W. Waage Ibrahim Mdala Hein Stigum Anne Karen Jenum Kåre I. Birkeland Nilam Shakeel Trond M. Michelsen Kåre R. Richardsen Line Sletner |
| author_sort | Christin W. Waage |
| collection | DOAJ |
| description | Abstract Background To describe ethnic differences in concentrations of lipids and lipoproteins, and their changes, during pregnancy to postpartum. Methods This was a population-based cohort study conducted in primary antenatal care in Norway. The participants (n = 806) were healthy, pregnant women, 59% were ethnic minorities. Outcomes were triglycerides, total cholesterol, HDL- and LDL-cholesterol, analysed from fasting blood samples drawn at gestational age (weeks) 15, 28 and 14 weeks postpartum. We performed linear regression models and linear mixed models to explore the total effect of ethnicity on the outcomes, adjusting for gestational age /week postpartum, maternal age and education. The analyses are corrected for multiple testing using the Bonferroni correction. Results At gestational age 15, triglyceride concentrations were lower in women of African origin (1.03 mmol/mol (95% CI: 0.90, 1.16)) and higher in women of South Asian (primarily Pakistan and Sri Lanka) origin (1.42 mmol/mol (1.35, 1.49)) and East Asian (primarily Vietnam, Philippines and Thailand) origin (1.58 mmol/mol (1.43, 1.73)) compared with Western Europeans (1.26 mmol/mol (1.20, 1.32)). Women of Asian and African origin had a smaller increase in triglycerides, LDL- and total cholesterol from gestational age 15 to 28. At gestational age 28, LDL-cholesterol levels were lowest among East Asians (3.03 mmol/mol (2.72, 3.34)) compared with Western Europeans (3.62 mmol/mol (3.50, 3.74)). Triglycerides and HDL-cholesterol were lower postpartum than at gestational age 15 in all groups, but the concentration of LDL-cholesterol was higher, except in Africans. South and East Asian women had lower HDL-cholesterol and higher triglycerides postpartum, while African women had lower triglycerides than Western Europeans. Conclusion We found significant differences in the concentrations of lipids and lipoproteins and their changes during pregnancy and the early postpartum period related to ethnic origin. |
| first_indexed | 2024-04-13T17:26:31Z |
| format | Article |
| id | doaj.art-ffebf5acd0424a20a36d66d08d98a77a |
| institution | Directory Open Access Journal |
| issn | 1471-2393 |
| language | English |
| last_indexed | 2024-04-13T17:26:31Z |
| publishDate | 2022-03-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Pregnancy and Childbirth |
| spelling | doaj.art-ffebf5acd0424a20a36d66d08d98a77a2022-12-22T02:37:46ZengBMCBMC Pregnancy and Childbirth1471-23932022-03-0122111210.1186/s12884-022-04524-2Lipid and lipoprotein concentrations during pregnancy and associations with ethnicityChristin W. Waage0Ibrahim Mdala1Hein Stigum2Anne Karen Jenum3Kåre I. Birkeland4Nilam Shakeel5Trond M. Michelsen6Kåre R. Richardsen7Line Sletner8General Practice Research Unit (AFE), Department of General Practice, Institute of Health and Society, University of OsloGeneral Practice Research Unit (AFE), Department of General Practice, Institute of Health and Society, University of OsloGeneral Practice Research Unit (AFE), Department of General Practice, Institute of Health and Society, University of OsloGeneral Practice Research Unit (AFE), Department of General Practice, Institute of Health and Society, University of OsloInstitute of Clinical Medicine, Faculty of Medicine, University of OsloGeneral Practice Research Unit (AFE), Department of General Practice, Institute of Health and Society, University of OsloInstitute of Clinical Medicine, Faculty of Medicine, University of OsloDepartment of Physiotherapy, Oslo Metropolitan UniversityInstitute of Clinical Medicine, Faculty of Medicine, University of OsloAbstract Background To describe ethnic differences in concentrations of lipids and lipoproteins, and their changes, during pregnancy to postpartum. Methods This was a population-based cohort study conducted in primary antenatal care in Norway. The participants (n = 806) were healthy, pregnant women, 59% were ethnic minorities. Outcomes were triglycerides, total cholesterol, HDL- and LDL-cholesterol, analysed from fasting blood samples drawn at gestational age (weeks) 15, 28 and 14 weeks postpartum. We performed linear regression models and linear mixed models to explore the total effect of ethnicity on the outcomes, adjusting for gestational age /week postpartum, maternal age and education. The analyses are corrected for multiple testing using the Bonferroni correction. Results At gestational age 15, triglyceride concentrations were lower in women of African origin (1.03 mmol/mol (95% CI: 0.90, 1.16)) and higher in women of South Asian (primarily Pakistan and Sri Lanka) origin (1.42 mmol/mol (1.35, 1.49)) and East Asian (primarily Vietnam, Philippines and Thailand) origin (1.58 mmol/mol (1.43, 1.73)) compared with Western Europeans (1.26 mmol/mol (1.20, 1.32)). Women of Asian and African origin had a smaller increase in triglycerides, LDL- and total cholesterol from gestational age 15 to 28. At gestational age 28, LDL-cholesterol levels were lowest among East Asians (3.03 mmol/mol (2.72, 3.34)) compared with Western Europeans (3.62 mmol/mol (3.50, 3.74)). Triglycerides and HDL-cholesterol were lower postpartum than at gestational age 15 in all groups, but the concentration of LDL-cholesterol was higher, except in Africans. South and East Asian women had lower HDL-cholesterol and higher triglycerides postpartum, while African women had lower triglycerides than Western Europeans. Conclusion We found significant differences in the concentrations of lipids and lipoproteins and their changes during pregnancy and the early postpartum period related to ethnic origin.https://doi.org/10.1186/s12884-022-04524-2EthnicityLipidsPregnancyPostpartum |
| spellingShingle | Christin W. Waage Ibrahim Mdala Hein Stigum Anne Karen Jenum Kåre I. Birkeland Nilam Shakeel Trond M. Michelsen Kåre R. Richardsen Line Sletner Lipid and lipoprotein concentrations during pregnancy and associations with ethnicity BMC Pregnancy and Childbirth Ethnicity Lipids Pregnancy Postpartum |
| title | Lipid and lipoprotein concentrations during pregnancy and associations with ethnicity |
| title_full | Lipid and lipoprotein concentrations during pregnancy and associations with ethnicity |
| title_fullStr | Lipid and lipoprotein concentrations during pregnancy and associations with ethnicity |
| title_full_unstemmed | Lipid and lipoprotein concentrations during pregnancy and associations with ethnicity |
| title_short | Lipid and lipoprotein concentrations during pregnancy and associations with ethnicity |
| title_sort | lipid and lipoprotein concentrations during pregnancy and associations with ethnicity |
| topic | Ethnicity Lipids Pregnancy Postpartum |
| url | https://doi.org/10.1186/s12884-022-04524-2 |
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