Obesity as potential breast cancer risk factor for postmenopausal women
Breast cancer is the second highest prevalent cancer globally after lung cancer with 2.09 million cases during 2018. Adults about 1.9 billion were overweight and over 650 million out of these were obese during 2016. There is a significant relationship between breast cancer risk and obesity. Prematur...
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
KeAi Communications Co., Ltd.
2021-03-01
|
| Series: | Genes and Diseases |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2352304219300753 |
| _version_ | 1797707632940679168 |
|---|---|
| author | Swati Sucharita Mohanty Prafulla Kumar Mohanty |
| author_facet | Swati Sucharita Mohanty Prafulla Kumar Mohanty |
| author_sort | Swati Sucharita Mohanty |
| collection | DOAJ |
| description | Breast cancer is the second highest prevalent cancer globally after lung cancer with 2.09 million cases during 2018. Adults about 1.9 billion were overweight and over 650 million out of these were obese during 2016. There is a significant relationship between breast cancer risk and obesity. Premature menopause and premenopausal obesity diminish the risk whereas postmenopausal obesity amplifies the risk, because adipose tissue acts as the major reservoir for estrogen biosynthesis after menopause. Lofty estrogen levels in serum along with enhanced peripheral site production of estrogen have been viewed as major reasons of developing breast cancer in overweight postmenopausal women. This review explains body fat as a peripheral site for estrogen biosynthesis, estrogen exposure affecting body fat distribution, and the mechanism of estrogen production from body fats. |
| first_indexed | 2024-03-12T06:10:15Z |
| format | Article |
| id | doaj.art-ffedb7833c564a949d20d83aa8ecb594 |
| institution | Directory Open Access Journal |
| issn | 2352-3042 |
| language | English |
| last_indexed | 2024-03-12T06:10:15Z |
| publishDate | 2021-03-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Genes and Diseases |
| spelling | doaj.art-ffedb7833c564a949d20d83aa8ecb5942023-09-03T03:13:54ZengKeAi Communications Co., Ltd.Genes and Diseases2352-30422021-03-0182117123Obesity as potential breast cancer risk factor for postmenopausal womenSwati Sucharita Mohanty0Prafulla Kumar Mohanty1Corresponding author.; Cytogenetics Laboratory, P.G. Department of Zoology, Utkal University, Bhubaneswar, 751004, Odisha, IndiaCytogenetics Laboratory, P.G. Department of Zoology, Utkal University, Bhubaneswar, 751004, Odisha, IndiaBreast cancer is the second highest prevalent cancer globally after lung cancer with 2.09 million cases during 2018. Adults about 1.9 billion were overweight and over 650 million out of these were obese during 2016. There is a significant relationship between breast cancer risk and obesity. Premature menopause and premenopausal obesity diminish the risk whereas postmenopausal obesity amplifies the risk, because adipose tissue acts as the major reservoir for estrogen biosynthesis after menopause. Lofty estrogen levels in serum along with enhanced peripheral site production of estrogen have been viewed as major reasons of developing breast cancer in overweight postmenopausal women. This review explains body fat as a peripheral site for estrogen biosynthesis, estrogen exposure affecting body fat distribution, and the mechanism of estrogen production from body fats.http://www.sciencedirect.com/science/article/pii/S2352304219300753AdipocyteAromataseBreast cancerEstrogenObesity |
| spellingShingle | Swati Sucharita Mohanty Prafulla Kumar Mohanty Obesity as potential breast cancer risk factor for postmenopausal women Genes and Diseases Adipocyte Aromatase Breast cancer Estrogen Obesity |
| title | Obesity as potential breast cancer risk factor for postmenopausal women |
| title_full | Obesity as potential breast cancer risk factor for postmenopausal women |
| title_fullStr | Obesity as potential breast cancer risk factor for postmenopausal women |
| title_full_unstemmed | Obesity as potential breast cancer risk factor for postmenopausal women |
| title_short | Obesity as potential breast cancer risk factor for postmenopausal women |
| title_sort | obesity as potential breast cancer risk factor for postmenopausal women |
| topic | Adipocyte Aromatase Breast cancer Estrogen Obesity |
| url | http://www.sciencedirect.com/science/article/pii/S2352304219300753 |
| work_keys_str_mv | AT swatisucharitamohanty obesityaspotentialbreastcancerriskfactorforpostmenopausalwomen AT prafullakumarmohanty obesityaspotentialbreastcancerriskfactorforpostmenopausalwomen |