Survival and Prognostic Factors for Outcome after Radiotherapy for T2 Glottic Carcinoma
Background: Local recurrence after radiotherapy for T2 glottic carcinoma remains an issue and identifying patients at risk for relapse is, therefore, important. This study aimed to assess the oncological outcomes and prognostic factors in a consecutive series of patients treated with radiotherapy fo...
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| Format: | Article |
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MDPI AG
2019-09-01
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| Series: | Cancers |
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| Online Access: | https://www.mdpi.com/2072-6694/11/9/1319 |
| _version_ | 1797708162629894144 |
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| author | Martine Hendriksma Marc A.P. van Ruler Berit M. Verbist Martin A. de Jong Ton P.M Langeveld Peter Paul G. van Benthem Elisabeth V. Sjögren |
| author_facet | Martine Hendriksma Marc A.P. van Ruler Berit M. Verbist Martin A. de Jong Ton P.M Langeveld Peter Paul G. van Benthem Elisabeth V. Sjögren |
| author_sort | Martine Hendriksma |
| collection | DOAJ |
| description | Background: Local recurrence after radiotherapy for T2 glottic carcinoma remains an issue and identifying patients at risk for relapse is, therefore, important. This study aimed to assess the oncological outcomes and prognostic factors in a consecutive series of patients treated with radiotherapy for T2N0 glottic carcinoma. Methods: Patients with T2N0 glottic carcinoma treated with radiotherapy were included in this retrospective study. Five- and ten-year local control (LC), overall survival (OS), disease-specific survival (DSS), and laryngeal preservation (LP) rates were calculated with the Kaplan−Meier method. The impact of prognostic variables was evaluated with the log-rank test. Results: Ninety-four patients were included for analysis. LC, OS, DSS, and LP rates were 70.5, 63.7, 86.0, and 74.7%, respectively at five years and 65.8, 41.0, 75.6, and 72.4% at 10 years. In total, 46 scans were included in the analyses. Vertical involvement of the anterior commissure on imaging showed a significant impact on LC. Conclusions:<b> </b>In accordance with previously described surgical risk factors, we identified vertical involvement of the anterior commissure on imaging as a prognostic factor for radiation failure. |
| first_indexed | 2024-03-12T06:18:20Z |
| format | Article |
| id | doaj.art-ffee2a8adc4142028eda818f0ff71506 |
| institution | Directory Open Access Journal |
| issn | 2072-6694 |
| language | English |
| last_indexed | 2024-03-12T06:18:20Z |
| publishDate | 2019-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cancers |
| spelling | doaj.art-ffee2a8adc4142028eda818f0ff715062023-09-03T02:27:47ZengMDPI AGCancers2072-66942019-09-01119131910.3390/cancers11091319cancers11091319Survival and Prognostic Factors for Outcome after Radiotherapy for T2 Glottic CarcinomaMartine Hendriksma0Marc A.P. van Ruler1Berit M. Verbist2Martin A. de Jong3Ton P.M Langeveld4Peter Paul G. van Benthem5Elisabeth V. Sjögren6Department of Otorhinolaryngology, Head & Neck Surgery, Leiden University Medical Center, 2300 RC Leiden, The NetherlandsDepartment of Radiation Oncology, Haaglanden Medical Center, 2300 RC The Hague, The NetherlandsDepartment of Radiology, Leiden University Medical Center, 2300 RC Leiden, The NetherlandsDepartment of Radiation Oncology, Leiden University Medical Center, 2300 RC Leiden, The NetherlandsDepartment of Otorhinolaryngology, Head & Neck Surgery, Leiden University Medical Center, 2300 RC Leiden, The NetherlandsDepartment of Otorhinolaryngology, Head & Neck Surgery, Leiden University Medical Center, 2300 RC Leiden, The NetherlandsDepartment of Otorhinolaryngology, Head & Neck Surgery, Leiden University Medical Center, 2300 RC Leiden, The NetherlandsBackground: Local recurrence after radiotherapy for T2 glottic carcinoma remains an issue and identifying patients at risk for relapse is, therefore, important. This study aimed to assess the oncological outcomes and prognostic factors in a consecutive series of patients treated with radiotherapy for T2N0 glottic carcinoma. Methods: Patients with T2N0 glottic carcinoma treated with radiotherapy were included in this retrospective study. Five- and ten-year local control (LC), overall survival (OS), disease-specific survival (DSS), and laryngeal preservation (LP) rates were calculated with the Kaplan−Meier method. The impact of prognostic variables was evaluated with the log-rank test. Results: Ninety-four patients were included for analysis. LC, OS, DSS, and LP rates were 70.5, 63.7, 86.0, and 74.7%, respectively at five years and 65.8, 41.0, 75.6, and 72.4% at 10 years. In total, 46 scans were included in the analyses. Vertical involvement of the anterior commissure on imaging showed a significant impact on LC. Conclusions:<b> </b>In accordance with previously described surgical risk factors, we identified vertical involvement of the anterior commissure on imaging as a prognostic factor for radiation failure.https://www.mdpi.com/2072-6694/11/9/1319early glottic cancerradiotherapylocal controlsurvivalanterior commissure |
| spellingShingle | Martine Hendriksma Marc A.P. van Ruler Berit M. Verbist Martin A. de Jong Ton P.M Langeveld Peter Paul G. van Benthem Elisabeth V. Sjögren Survival and Prognostic Factors for Outcome after Radiotherapy for T2 Glottic Carcinoma Cancers early glottic cancer radiotherapy local control survival anterior commissure |
| title | Survival and Prognostic Factors for Outcome after Radiotherapy for T2 Glottic Carcinoma |
| title_full | Survival and Prognostic Factors for Outcome after Radiotherapy for T2 Glottic Carcinoma |
| title_fullStr | Survival and Prognostic Factors for Outcome after Radiotherapy for T2 Glottic Carcinoma |
| title_full_unstemmed | Survival and Prognostic Factors for Outcome after Radiotherapy for T2 Glottic Carcinoma |
| title_short | Survival and Prognostic Factors for Outcome after Radiotherapy for T2 Glottic Carcinoma |
| title_sort | survival and prognostic factors for outcome after radiotherapy for t2 glottic carcinoma |
| topic | early glottic cancer radiotherapy local control survival anterior commissure |
| url | https://www.mdpi.com/2072-6694/11/9/1319 |
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