Association of cerebellar and pre-motor cortex gray matter density with subjective intoxication and subjective response following acute alcohol intake
Abstract Acute alcohol intake produces subjective intoxication (SI) and response (SR; e.g., valanced stimulation and sedation), which has important implications for alcohol-related risk. Individuals who experience less SI may be more likely to engage in risky behaviors while drinking. Gray matter mo...
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| Format: | Article |
| Language: | English |
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Nature Portfolio
2023-05-01
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| Series: | Scientific Reports |
| Online Access: | https://doi.org/10.1038/s41598-023-34546-5 |
| _version_ | 1797832130873524224 |
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| author | Bethany A. Stennett-Blackmon Landrew Sevel Jeff Boissoneault |
| author_facet | Bethany A. Stennett-Blackmon Landrew Sevel Jeff Boissoneault |
| author_sort | Bethany A. Stennett-Blackmon |
| collection | DOAJ |
| description | Abstract Acute alcohol intake produces subjective intoxication (SI) and response (SR; e.g., valanced stimulation and sedation), which has important implications for alcohol-related risk. Individuals who experience less SI may be more likely to engage in risky behaviors while drinking. Gray matter morphometry in brain regions underlying cognitive and affective processes may help to inform individual differences in subjective intoxication and response. The subjective effects of alcohol vary between limbs of the blood alcohol concentration (BAC) curve (i.e., whether BAC is rising or falling; acute tolerance). We examined the relationship between gray matter density (GMD) and SI/SR as a function of BAC limb. Healthy social drinkers (N = 89; 55 women) completed an alcohol challenge paradigm (target BAC = 0.08 g/dL) and structural magnetic resonance imaging (MRI). Participants completed measures of SR and SI on ascending and descending BAC limbs. Association between GMD and SI/SR on each limb were assessed using whole-brain, voxel-wise general linear models. GMD estimates were extracted from significant clusters. Differences in association of GMD and SI/SR between limbs were assessed using hierarchical regression. Significant associations of SI with GMD on the ascending limb were observed in the cerebellum. A significant association between SR and GMD on the descending limb were observed in the pre-motor cortex (BA6) and cerebellum. We identified common and unique associations among cerebellum and pre-central gyrus structures with SI and SR between BAC limbs. Functional imaging studies may further clarify unique dimensions of subjective alcohol effects linked to the observed structural associations. |
| first_indexed | 2024-04-09T14:02:51Z |
| format | Article |
| id | doaj.art-ffee5c1bf3c040799bb8bc2aee09ab3c |
| institution | Directory Open Access Journal |
| issn | 2045-2322 |
| language | English |
| last_indexed | 2024-04-09T14:02:51Z |
| publishDate | 2023-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Scientific Reports |
| spelling | doaj.art-ffee5c1bf3c040799bb8bc2aee09ab3c2023-05-07T11:13:24ZengNature PortfolioScientific Reports2045-23222023-05-011311810.1038/s41598-023-34546-5Association of cerebellar and pre-motor cortex gray matter density with subjective intoxication and subjective response following acute alcohol intakeBethany A. Stennett-Blackmon0Landrew Sevel1Jeff Boissoneault2Department of Clinical and Health Psychology, University of FloridaOsher Center for Integrative Health, Vanderbilt University Medical CenterDepartment of Clinical and Health Psychology, University of FloridaAbstract Acute alcohol intake produces subjective intoxication (SI) and response (SR; e.g., valanced stimulation and sedation), which has important implications for alcohol-related risk. Individuals who experience less SI may be more likely to engage in risky behaviors while drinking. Gray matter morphometry in brain regions underlying cognitive and affective processes may help to inform individual differences in subjective intoxication and response. The subjective effects of alcohol vary between limbs of the blood alcohol concentration (BAC) curve (i.e., whether BAC is rising or falling; acute tolerance). We examined the relationship between gray matter density (GMD) and SI/SR as a function of BAC limb. Healthy social drinkers (N = 89; 55 women) completed an alcohol challenge paradigm (target BAC = 0.08 g/dL) and structural magnetic resonance imaging (MRI). Participants completed measures of SR and SI on ascending and descending BAC limbs. Association between GMD and SI/SR on each limb were assessed using whole-brain, voxel-wise general linear models. GMD estimates were extracted from significant clusters. Differences in association of GMD and SI/SR between limbs were assessed using hierarchical regression. Significant associations of SI with GMD on the ascending limb were observed in the cerebellum. A significant association between SR and GMD on the descending limb were observed in the pre-motor cortex (BA6) and cerebellum. We identified common and unique associations among cerebellum and pre-central gyrus structures with SI and SR between BAC limbs. Functional imaging studies may further clarify unique dimensions of subjective alcohol effects linked to the observed structural associations.https://doi.org/10.1038/s41598-023-34546-5 |
| spellingShingle | Bethany A. Stennett-Blackmon Landrew Sevel Jeff Boissoneault Association of cerebellar and pre-motor cortex gray matter density with subjective intoxication and subjective response following acute alcohol intake Scientific Reports |
| title | Association of cerebellar and pre-motor cortex gray matter density with subjective intoxication and subjective response following acute alcohol intake |
| title_full | Association of cerebellar and pre-motor cortex gray matter density with subjective intoxication and subjective response following acute alcohol intake |
| title_fullStr | Association of cerebellar and pre-motor cortex gray matter density with subjective intoxication and subjective response following acute alcohol intake |
| title_full_unstemmed | Association of cerebellar and pre-motor cortex gray matter density with subjective intoxication and subjective response following acute alcohol intake |
| title_short | Association of cerebellar and pre-motor cortex gray matter density with subjective intoxication and subjective response following acute alcohol intake |
| title_sort | association of cerebellar and pre motor cortex gray matter density with subjective intoxication and subjective response following acute alcohol intake |
| url | https://doi.org/10.1038/s41598-023-34546-5 |
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