A novel hyaluronidase from brown spider (Loxosceles intermedia) venom (Dietrich's Hyaluronidase): from cloning to functional characterization.

A novel hyaluronidase from brown spider (Loxosceles intermedia) venom (Dietrich's Hyaluronidase): from cloning to functional characterization.

Loxoscelism is the designation given to clinical symptoms evoked by Loxosceles spider's bites. Clinical manifestations include skin necrosis with gravitational spreading and systemic disturbs. The venom contains several enzymatic toxins. Herein, we describe the cloning, expression, refolding an...

Full description

Bibliographic Details
Main Authors:	Valéria Pereira Ferrer, Thiago Lopes de Mari, Luiza Helena Gremski, Dilza Trevisan Silva, Rafael Bertoni da Silveira, Waldemiro Gremski, Olga Meiri Chaim, Andrea Senff-Ribeiro, Helena Bonciani Nader, Silvio Sanches Veiga
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2013-01-01
Series:	PLoS Neglected Tropical Diseases
Online Access:	http://europepmc.org/articles/PMC3642055?pdf=render

Similar Items

Brown Spider (Loxosceles genus) Venom Toxins: Tools for Biological Purposes
by: Andrea Senff-Ribeiro, et al.
Published: (2011-03-01)

TCTP from <i>Loxosceles Intermedia</i> (Brown Spider) Venom Contributes to the Allergic and Inflammatory Response of Cutaneous Loxoscelism
by: Marianna Boia-Ferreira, et al.
Published: (2019-11-01)

Insights into brown spider and loxoscelism
by: MH Appel, et al.
Published: (2005-12-01)

Insights into brown spider and loxoscelism
by: M H Appel, et al.
Published: (2005-12-01)

Brown Spider (<i>Loxosceles</i>) Venom Toxins as Potential Biotools for the Development of Novel Therapeutics
by: Daniele Chaves-Moreira, et al.
Published: (2019-06-01)

Comparative Biochemical, Structural, and Functional Analysis of Recombinant Phospholipases D from Three <i>Loxosceles</i> Spider Venoms
by: Hanna Câmara da Justa, et al.
Published: (2023-07-01)

Highlights in the knowledge of brown spider toxins
by: Daniele Chaves-Moreira, et al.
Published: (2017-03-01)

Evaluation of the effects of Loxosceles intermedia’s venom in zebrafish
by: Ollavo Nogueira Tozzi, et al.
Published: (2022-01-01)

Purification and characterization of a hyaluronidase from venom of the spider Vitalius dubius (Araneae, Theraphosidae)
by: Rafael Sutti, et al.
Published: (2014-02-01)

Brown Spider Venom Phospholipase-D Activity upon Different Lipid Substrates
by: Daniele Chaves-Moreira, et al.
Published: (2023-01-01)

The hyaluronidase activities of some Southeast Asian snake venoms.
by: Pukrittayakamee, S, et al.
Published: (1988)

Isolation, N-glycosylations and Function of a Hyaluronidase-Like Enzyme from the Venom of the Spider Cupiennius salei.
by: Olivier Biner, et al.
Published: (2015-01-01)

Experiences with hyaluronidase
by: Mascati Naumann
Published: (1953-01-01)

Effects of copaiba oil on dermonecrosis induced by Loxosceles intermedia venom
by: Mara Fernandes Ribeiro, et al.
Published: (2019-04-01)

Hyaluronidases in Human Diseases
by: Aditya Kaul, et al.
Published: (2021-03-01)

Hyaluronan breakdown by snake venom hyaluronidases: From toxins delivery to immunopathology
by: Felipe Silva de França, et al.
Published: (2023-03-01)

Arthropod venom Hyaluronidases: biochemical properties and potential applications in medicine and biotechnology
by: Karla C F Bordon, et al.
Published: (2015-11-01)

Extracellular matrix molecules as targets for brown spider venom toxins
by: S.S. Veiga, et al.
Published: (2001-07-01)

Forty Years of the Description of Brown Spider Venom Phospholipases-D
by: Luiza Helena Gremski, et al.
Published: (2020-03-01)

Characterization of a monoclonal antibody that neutralizes the hyaluronidase activity of Russell's viper venom.
by: Pukrittayakamee, S, et al.
Published: (1990)

Involvement of hyaluronidases in colorectal cancer
by: Bouga Helen, et al.
Published: (2010-09-01)

Hyaluronidase sensitivity: Our experience
by: Rahul Mayor, et al.
Published: (2016-01-01)

Systemic Loxoscelism, Less Frequent but More Deadly: The Involvement of Phospholipases D in the Pathophysiology of Envenomation
by: Luiza Helena Gremski, et al.
Published: (2022-12-01)

Evaluation of the efficacy of vacuum cleaners for the integrated control of brown spider Loxosceles intermedia
by: E. N. Ramires, et al.
Published: (2007-01-01)

Tetracycline Reduces Kidney Damage Induced by Loxosceles Spider Venom
by: Cinthya Kimori Okamoto, et al.
Published: (2017-03-01)

Pioneering Study on Rhopalurus crassicauda Scorpion Venom: Isolation and Characterization of the Major Toxin and Hyaluronidase
by: Caio B. Abreu, et al.
Published: (2020-08-01)

Prospective Use of Brown Spider Venom Toxins as Therapeutic and Biotechnological Inputs
by: Luiza Helena Gremski, et al.
Published: (2021-06-01)

Study of the immunotoxic properties of pegylated hyaluronidase
by: K. I. Ershov, et al.
Published: (2023-10-01)

Periorbital myxedema treated with intralesional hyaluronidase
by: Aleksandra L. Lindgren, et al.
Published: (2020-09-01)

Role of Hyaluronidase (Hyalase) in management of pterygium
by: Rohatgi Rajendra, et al.
Published: (1971-01-01)

Protective Effectiveness of an Immunization Protocol Against the Toxic Effects of Loxosceles intermedia Venom in Rabbits
by: Ana Luísa Soares de Miranda, et al.
Published: (2022-05-01)

Isolation and Identification of Hyaluronidase Producing Staphylococcus aureus
by: Furqan M. K, et al.
Published: (2016-06-01)

Industrialization possibilities of purified pig sperm hyaluronidase
by: Soojin Park, et al.
Published: (2023-11-01)

Hyaluronidase pharmacological properties and clinical application in ophthalmology
by: V. E. Zabanova, et al.
Published: (2020-08-01)

Observaticns On The Treatment Of Ganglion With Intralesisonal Injection Of Hyaluronidase
by: Dy. Ila Saha, et al.
Published: (1981-12-01)

Hyaluronidase facilitated subcutaneous immunoglobulin in primary immunodeficiency
by: Jolles S
Published: (2013-09-01)

Pretibial myxedema treated with intralesional hyaluronidase and triamcinolone
by: Natalie Kudlak, DO, et al.
Published: (2020-09-01)

Cloning and expression of the enzymatic region of Streptococcal hyaluronidase
by: Nafiseh Al-Sadat Mirjamali, et al.
Published: (2014-09-01)

Structure-based virtual screening to predict Loxosceles spider venom natural inhibitors
by: Haitham Ahmed Al-Madhagi
Published: (2023-03-01)

<i>Loxosceles gaucho</i> Spider Venom: An Untapped Source of Antimicrobial Agents
by: Paula J Segura-Ramírez, et al.
Published: (2018-12-01)