A moderate dosage of coffee causes acute retinal capillary perfusion decrease in healthy young individuals
Abstract Aim: Caffeinated beverages are very popular across populations and cultures, but quantitative evidence of the acute effects of moderate coffee doses on retinal perfusion is sparse and contradicting. Thus, the aim of this randomized, cross-over and parallel-group design study was to investig...
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| Format: | Article |
| Language: | English |
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BMC
2022-11-01
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| Series: | BMC Ophthalmology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12886-022-02638-x |
| _version_ | 1811208078449704960 |
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| author | Xiaofeng Zhu Jiong Zhu Yongyi Wang Zhongdi Chu Ruikang K. Wang Yi Xu Lina Lu Haidong Zou |
| author_facet | Xiaofeng Zhu Jiong Zhu Yongyi Wang Zhongdi Chu Ruikang K. Wang Yi Xu Lina Lu Haidong Zou |
| author_sort | Xiaofeng Zhu |
| collection | DOAJ |
| description | Abstract Aim: Caffeinated beverages are very popular across populations and cultures, but quantitative evidence of the acute effects of moderate coffee doses on retinal perfusion is sparse and contradicting. Thus, the aim of this randomized, cross-over and parallel-group design study was to investigate whether moderate consumption of coffee alters macular retinal capillary perfusion in young healthy individuals. Methods: Twenty-seven young healthy individuals were recruited for this study. Acute changes in retinal microvasculature were assessed using spectral-domain optical coherence tomography angiography (SD-OCTA) at baseline, 0.5 h, and 2 h after intake of coffee, or water. Meanwhile, cerebral blood flow (CBF) and retina-choroid blood flow were evaluated in a parallel-group design (4 participants each in coffee or water group) using magnetic resonance imaging (MRI) with pseudo-continuous arterial spin labeling sequences. Results: Two hours after coffee intake, blood caffeine concentration increased from 0 to 5.05 ± 1.36 µg/mL. Coffee caused a significant decrease in retinal vessel diameter index (VDI) (19.05 ± 0.24 versus [vs] 19.13 ± 0.26; p < 0.001) and CBF in the frontal lobe (77.47 ± 15.21 mL/100 mL/min vs. 84.13 ± 15.55 mL/100 mL/min; p < 0.05) 2 h after intake. However, it significantly increased retina-choroid blood flow after 0.5 and 2 h (163.18 ± 61.07 mL/100 mL/min vs. 132.68 ± 70.47 mL/100 mL/min, p < 0.001, and 161.21 ± 47.95 vs. 132.68 ± 70.47; p < 0.001, respectively). Conclusion: This is the first study to demonstrate the acute effects of daily dose coffee consumption on retinal capillary perfusion using SD-OCTA combinate with blood flow MRI. The findings imply that although moderate coffee intake caused a significant increase in retina-choroid blood flow, there was a significant acute decrease both in macular retinal capillary perfusion and CBF. |
| first_indexed | 2024-04-12T04:16:17Z |
| format | Article |
| id | doaj.art-fff19c8b93274d088594c66a61d273a4 |
| institution | Directory Open Access Journal |
| issn | 1471-2415 |
| language | English |
| last_indexed | 2024-04-12T04:16:17Z |
| publishDate | 2022-11-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Ophthalmology |
| spelling | doaj.art-fff19c8b93274d088594c66a61d273a42022-12-22T03:48:24ZengBMCBMC Ophthalmology1471-24152022-11-0122111010.1186/s12886-022-02638-xA moderate dosage of coffee causes acute retinal capillary perfusion decrease in healthy young individualsXiaofeng Zhu0Jiong Zhu1Yongyi Wang2Zhongdi Chu3Ruikang K. Wang4Yi Xu5Lina Lu6Haidong Zou7Department of Preventive Ophthalmology, Shanghai Eye Disease Prevention and Treatment Center, Shanghai Eye HospitalDepartment of Radiology, Renji Hospital, Shanghai Jiao Tong University School of MedicineDepartment of Medical Administration, Huizhou First HospitalDepartments of Bioengineering and Ophthalmology, University of WashingtonDepartments of Bioengineering and Ophthalmology, University of WashingtonDepartment of Preventive Ophthalmology, Shanghai Eye Disease Prevention and Treatment Center, Shanghai Eye HospitalDepartment of Preventive Ophthalmology, Shanghai Eye Disease Prevention and Treatment Center, Shanghai Eye HospitalDepartment of Preventive Ophthalmology, Shanghai Eye Disease Prevention and Treatment Center, Shanghai Eye HospitalAbstract Aim: Caffeinated beverages are very popular across populations and cultures, but quantitative evidence of the acute effects of moderate coffee doses on retinal perfusion is sparse and contradicting. Thus, the aim of this randomized, cross-over and parallel-group design study was to investigate whether moderate consumption of coffee alters macular retinal capillary perfusion in young healthy individuals. Methods: Twenty-seven young healthy individuals were recruited for this study. Acute changes in retinal microvasculature were assessed using spectral-domain optical coherence tomography angiography (SD-OCTA) at baseline, 0.5 h, and 2 h after intake of coffee, or water. Meanwhile, cerebral blood flow (CBF) and retina-choroid blood flow were evaluated in a parallel-group design (4 participants each in coffee or water group) using magnetic resonance imaging (MRI) with pseudo-continuous arterial spin labeling sequences. Results: Two hours after coffee intake, blood caffeine concentration increased from 0 to 5.05 ± 1.36 µg/mL. Coffee caused a significant decrease in retinal vessel diameter index (VDI) (19.05 ± 0.24 versus [vs] 19.13 ± 0.26; p < 0.001) and CBF in the frontal lobe (77.47 ± 15.21 mL/100 mL/min vs. 84.13 ± 15.55 mL/100 mL/min; p < 0.05) 2 h after intake. However, it significantly increased retina-choroid blood flow after 0.5 and 2 h (163.18 ± 61.07 mL/100 mL/min vs. 132.68 ± 70.47 mL/100 mL/min, p < 0.001, and 161.21 ± 47.95 vs. 132.68 ± 70.47; p < 0.001, respectively). Conclusion: This is the first study to demonstrate the acute effects of daily dose coffee consumption on retinal capillary perfusion using SD-OCTA combinate with blood flow MRI. The findings imply that although moderate coffee intake caused a significant increase in retina-choroid blood flow, there was a significant acute decrease both in macular retinal capillary perfusion and CBF.https://doi.org/10.1186/s12886-022-02638-xRetinal microcirculationRetinal capillary perfusionCaffeine consumptionSpectral-domain optical coherence tomography angiographyMagnetic resonance imaging |
| spellingShingle | Xiaofeng Zhu Jiong Zhu Yongyi Wang Zhongdi Chu Ruikang K. Wang Yi Xu Lina Lu Haidong Zou A moderate dosage of coffee causes acute retinal capillary perfusion decrease in healthy young individuals BMC Ophthalmology Retinal microcirculation Retinal capillary perfusion Caffeine consumption Spectral-domain optical coherence tomography angiography Magnetic resonance imaging |
| title | A moderate dosage of coffee causes acute retinal capillary perfusion decrease in healthy young individuals |
| title_full | A moderate dosage of coffee causes acute retinal capillary perfusion decrease in healthy young individuals |
| title_fullStr | A moderate dosage of coffee causes acute retinal capillary perfusion decrease in healthy young individuals |
| title_full_unstemmed | A moderate dosage of coffee causes acute retinal capillary perfusion decrease in healthy young individuals |
| title_short | A moderate dosage of coffee causes acute retinal capillary perfusion decrease in healthy young individuals |
| title_sort | moderate dosage of coffee causes acute retinal capillary perfusion decrease in healthy young individuals |
| topic | Retinal microcirculation Retinal capillary perfusion Caffeine consumption Spectral-domain optical coherence tomography angiography Magnetic resonance imaging |
| url | https://doi.org/10.1186/s12886-022-02638-x |
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