In situ X-ray-assisted electron microscopy staining for large biological samples

In situ X-ray-assisted electron microscopy staining for large biological samples

Electron microscopy of biological tissue has recently seen an unprecedented increase in imaging throughput moving the ultrastructural analysis of large tissue blocks such as whole brains into the realm of the feasible. However, homogeneous, high-quality electron microscopy staining of large biologic...

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Bibliographic Details
Main Authors: Sebastian Ströh, Eric W Hammerschmith, David W Tank, H Sebastian Seung, Adrian Andreas Wanner
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2022-10-01
Series:eLife
Subjects:
electron microscopy
osmium staining
whole brain
connectomics
Online Access:https://elifesciences.org/articles/72147

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