Antibiotic use in Brazilian hospitals in the 21st century: a systematic review
Abstract INTRODUCTION This systematic review aimed to assess antibiotic use in Brazilian hospitals in the 21st century, as well as to understand the different drug utilization metrics adopted to assess the consumption of these drugs. METHODS We systematically reviewed five databases (MEDLINE [Me...
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| Format: | Article |
| Language: | English |
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Sociedade Brasileira de Medicina Tropical (SBMT)
2021-06-01
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| Series: | Revista da Sociedade Brasileira de Medicina Tropical |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822021000100325&tlng=en |
| _version_ | 1817978955523686400 |
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| author | Lucas Borges Pereira Maria Olívia Barboza Zanetti Larissa Pombeiro Sponchiado João Paulo Vilela Rodrigues Marília Silveira de Almeida Campos Fabiana Rossi Varallo Leonardo Régis Leira Pereira |
| author_facet | Lucas Borges Pereira Maria Olívia Barboza Zanetti Larissa Pombeiro Sponchiado João Paulo Vilela Rodrigues Marília Silveira de Almeida Campos Fabiana Rossi Varallo Leonardo Régis Leira Pereira |
| author_sort | Lucas Borges Pereira |
| collection | DOAJ |
| description | Abstract INTRODUCTION This systematic review aimed to assess antibiotic use in Brazilian hospitals in the 21st century, as well as to understand the different drug utilization metrics adopted to assess the consumption of these drugs. METHODS We systematically reviewed five databases (MEDLINE [Medical Literature Analysis and Retrieval System Online], CENTRAL [The Cochrane Central Register of Controlled Trials], EMBASE® [Excerpta Medica Database], Scopus [Elsevier’s abstract and citation database], and LILACS [Literatura Latino-Americana e do Caribe em Ciências da Saúde]) for observational or experimental studies that assessed antibiotic utilization in Brazilian hospitals. The main outcomes were the drug utilization metrics and the consumption of antibiotics. RESULTS We included 23 studies, of which 43.5% were carried out in adult and pediatric care units, 39.1% in adult units, and 17.4% in pediatric units. Regarding the complexity of healthcare, 26.1% of the studies were performed in intensive care units. Two drug utilization metrics were used in these studies: the defined daily dose (DDD) and the percentage of antibiotic prescriptions. The most commonly used antibiotic classes were third-generation cephalosporins, carbapenems, fluoroquinolones, and combinations of penicillins when the DDD was the adopted drug utilization metric. CONCLUSIONS Although few studies have been conducted, existing data indicate a high use of broad-spectrum antibiotics. We found that the lack of standardized antibiotic utilization metrics impaired the mapping of drug consumption at the national level. |
| first_indexed | 2024-04-13T22:36:46Z |
| format | Article |
| id | doaj.art-fff4887ea642489ab7b39380299b2dc3 |
| institution | Directory Open Access Journal |
| issn | 1678-9849 |
| language | English |
| last_indexed | 2024-04-13T22:36:46Z |
| publishDate | 2021-06-01 |
| publisher | Sociedade Brasileira de Medicina Tropical (SBMT) |
| record_format | Article |
| series | Revista da Sociedade Brasileira de Medicina Tropical |
| spelling | doaj.art-fff4887ea642489ab7b39380299b2dc32022-12-22T02:26:46ZengSociedade Brasileira de Medicina Tropical (SBMT)Revista da Sociedade Brasileira de Medicina Tropical1678-98492021-06-015410.1590/0037-8682-0861-2020Antibiotic use in Brazilian hospitals in the 21st century: a systematic reviewLucas Borges Pereirahttps://orcid.org/0000-0002-5957-9286Maria Olívia Barboza Zanettihttps://orcid.org/0000-0002-9551-4711Larissa Pombeiro Sponchiadohttps://orcid.org/0000-0003-1469-4034João Paulo Vilela Rodrigueshttps://orcid.org/0000-0002-5785-1418Marília Silveira de Almeida Camposhttps://orcid.org/0000-0003-2420-4641Fabiana Rossi Varallohttps://orcid.org/0000-0003-4016-1442Leonardo Régis Leira Pereirahttps://orcid.org/0000-0002-8609-1390Abstract INTRODUCTION This systematic review aimed to assess antibiotic use in Brazilian hospitals in the 21st century, as well as to understand the different drug utilization metrics adopted to assess the consumption of these drugs. METHODS We systematically reviewed five databases (MEDLINE [Medical Literature Analysis and Retrieval System Online], CENTRAL [The Cochrane Central Register of Controlled Trials], EMBASE® [Excerpta Medica Database], Scopus [Elsevier’s abstract and citation database], and LILACS [Literatura Latino-Americana e do Caribe em Ciências da Saúde]) for observational or experimental studies that assessed antibiotic utilization in Brazilian hospitals. The main outcomes were the drug utilization metrics and the consumption of antibiotics. RESULTS We included 23 studies, of which 43.5% were carried out in adult and pediatric care units, 39.1% in adult units, and 17.4% in pediatric units. Regarding the complexity of healthcare, 26.1% of the studies were performed in intensive care units. Two drug utilization metrics were used in these studies: the defined daily dose (DDD) and the percentage of antibiotic prescriptions. The most commonly used antibiotic classes were third-generation cephalosporins, carbapenems, fluoroquinolones, and combinations of penicillins when the DDD was the adopted drug utilization metric. CONCLUSIONS Although few studies have been conducted, existing data indicate a high use of broad-spectrum antibiotics. We found that the lack of standardized antibiotic utilization metrics impaired the mapping of drug consumption at the national level.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822021000100325&tlng=enDrug utilizationPharmacoepidemiologyAnti-bacterial agentesDrug resistanceBacteriaAntimicrobial stewardship |
| spellingShingle | Lucas Borges Pereira Maria Olívia Barboza Zanetti Larissa Pombeiro Sponchiado João Paulo Vilela Rodrigues Marília Silveira de Almeida Campos Fabiana Rossi Varallo Leonardo Régis Leira Pereira Antibiotic use in Brazilian hospitals in the 21st century: a systematic review Revista da Sociedade Brasileira de Medicina Tropical Drug utilization Pharmacoepidemiology Anti-bacterial agentes Drug resistance Bacteria Antimicrobial stewardship |
| title | Antibiotic use in Brazilian hospitals in the 21st century: a systematic review |
| title_full | Antibiotic use in Brazilian hospitals in the 21st century: a systematic review |
| title_fullStr | Antibiotic use in Brazilian hospitals in the 21st century: a systematic review |
| title_full_unstemmed | Antibiotic use in Brazilian hospitals in the 21st century: a systematic review |
| title_short | Antibiotic use in Brazilian hospitals in the 21st century: a systematic review |
| title_sort | antibiotic use in brazilian hospitals in the 21st century a systematic review |
| topic | Drug utilization Pharmacoepidemiology Anti-bacterial agentes Drug resistance Bacteria Antimicrobial stewardship |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0037-86822021000100325&tlng=en |
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