Bone Allografts: Products and Clinical Applications in Iran
Bone allografts have become an accepted technology to replace bone loss due to common diseases, such as tumor resection, trauma, and failed total joint arthroplasty. This study briefly reviews a branch of regenerative medicine related to bone allografts and its related aspects. As new allografts sti...
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| Format: | Article |
| Language: | English |
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Urmia University of Medical Sciences
2021-11-01
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| Series: | Journal of Research in Applied and Basic Medical Sciences |
| Subjects: | |
| Online Access: | http://ijrabms.umsu.ac.ir/article-1-154-en.pdf |
| _version_ | 1797743352260591616 |
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| author | Ali Golchin Reza Samanipour Parviz Ranjbarvan |
| author_facet | Ali Golchin Reza Samanipour Parviz Ranjbarvan |
| author_sort | Ali Golchin |
| collection | DOAJ |
| description | Bone allografts have become an accepted technology to replace bone loss due to common diseases, such as tumor resection, trauma, and failed total joint arthroplasty. This study briefly reviews a branch of regenerative medicine related to bone allografts and its related aspects. As new allografts stimulate an immune rejection response, bone grafts are usually prepared by freezing or freeze-drying to decrease the immune system responses. The notable biological events of associations, such as hemorrhage and inflammation, osteogenesis, osteoinduction, osteoconduction, and impressive remodeling, result in a load-bearing structure. Generally, cancellous allografts are effectively incorporated, while cortical grafts remain an admixture of viable regenerated bone and old necrotic bone for a prolonged duration. Massive bone allografts used in reconstructing tumor resection have a long-term successful outcome in about 80 percent of the procedures. Similar success has been reported for its use in total joint revision surgery and other clinical applications. The significant complications reported for grafting procedures are infection, bone graft fracture, nonunion at the graft-host juncture, and rare massive allograft resorption. Although bone allografting is a successful therapeutic approach, emerging technologies will introduce more efficient bones by mobilizing the adjunctive growth factors, cell and gene-based therapies, and tissue engineering techniques. The primary and applicable knowledge of bone allografts is essential; however, continual investigations are necessary. |
| first_indexed | 2024-03-12T14:55:13Z |
| format | Article |
| id | doaj.art-fff652f182ef4538b5c6d5fcff833973 |
| institution | Directory Open Access Journal |
| issn | 2717-0098 |
| language | English |
| last_indexed | 2024-03-12T14:55:13Z |
| publishDate | 2021-11-01 |
| publisher | Urmia University of Medical Sciences |
| record_format | Article |
| series | Journal of Research in Applied and Basic Medical Sciences |
| spelling | doaj.art-fff652f182ef4538b5c6d5fcff8339732023-08-15T04:52:27ZengUrmia University of Medical SciencesJournal of Research in Applied and Basic Medical Sciences2717-00982021-11-01729499Bone Allografts: Products and Clinical Applications in IranAli Golchin0Reza Samanipour1Parviz Ranjbarvan2 Regenerative Medicine Group (REMED), Universal Scientific Education and Research Network (USERN), Tehran, Iran; Department of Tissue Engineering and Applied Cell Sciences, School of Advanced Technologies in Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran Regenerative Medicine Group (REMED), Universal Scientific Education and Research Network (USERN), Tehran, Iran; Bone allografts have become an accepted technology to replace bone loss due to common diseases, such as tumor resection, trauma, and failed total joint arthroplasty. This study briefly reviews a branch of regenerative medicine related to bone allografts and its related aspects. As new allografts stimulate an immune rejection response, bone grafts are usually prepared by freezing or freeze-drying to decrease the immune system responses. The notable biological events of associations, such as hemorrhage and inflammation, osteogenesis, osteoinduction, osteoconduction, and impressive remodeling, result in a load-bearing structure. Generally, cancellous allografts are effectively incorporated, while cortical grafts remain an admixture of viable regenerated bone and old necrotic bone for a prolonged duration. Massive bone allografts used in reconstructing tumor resection have a long-term successful outcome in about 80 percent of the procedures. Similar success has been reported for its use in total joint revision surgery and other clinical applications. The significant complications reported for grafting procedures are infection, bone graft fracture, nonunion at the graft-host juncture, and rare massive allograft resorption. Although bone allografting is a successful therapeutic approach, emerging technologies will introduce more efficient bones by mobilizing the adjunctive growth factors, cell and gene-based therapies, and tissue engineering techniques. The primary and applicable knowledge of bone allografts is essential; however, continual investigations are necessary.http://ijrabms.umsu.ac.ir/article-1-154-en.pdfbone allograftsbone regenerationregenerative medicineorthopedic surgerydentistry |
| spellingShingle | Ali Golchin Reza Samanipour Parviz Ranjbarvan Bone Allografts: Products and Clinical Applications in Iran Journal of Research in Applied and Basic Medical Sciences bone allografts bone regeneration regenerative medicine orthopedic surgery dentistry |
| title | Bone Allografts: Products and Clinical Applications in Iran |
| title_full | Bone Allografts: Products and Clinical Applications in Iran |
| title_fullStr | Bone Allografts: Products and Clinical Applications in Iran |
| title_full_unstemmed | Bone Allografts: Products and Clinical Applications in Iran |
| title_short | Bone Allografts: Products and Clinical Applications in Iran |
| title_sort | bone allografts products and clinical applications in iran |
| topic | bone allografts bone regeneration regenerative medicine orthopedic surgery dentistry |
| url | http://ijrabms.umsu.ac.ir/article-1-154-en.pdf |
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