Within subject rise in serum TNFα to IL-10 ratio is associated with poorer attention, decision-making and working memory in jockeys
Jockeys work in high-risk environments that rely heavily on attention- and decision-making to perform well and safely. Workplace stress literature has often overlooked the impact of stress on cognition, and designs that include physiological measures are rare. This study assessed the prospective con...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2022-05-01
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| Series: | Comprehensive Psychoneuroendocrinology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666497622000224 |
| _version_ | 1818275122574786560 |
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| author | Stefan Piantella William T. O'Brien Matthew W. Hale Paul Maruff Stuart J. McDonald Bradley J. Wright |
| author_facet | Stefan Piantella William T. O'Brien Matthew W. Hale Paul Maruff Stuart J. McDonald Bradley J. Wright |
| author_sort | Stefan Piantella |
| collection | DOAJ |
| description | Jockeys work in high-risk environments that rely heavily on attention- and decision-making to perform well and safely. Workplace stress literature has often overlooked the impact of stress on cognition, and designs that include physiological measures are rare. This study assessed the prospective concurrent relationships between workplace stress, depression symptoms and low-grade inflammation with cognitive performance among professional jockeys. Professional jockeys (N = 35, Mage = 32.29) provided information on workplace stress and depression symptoms, with serum levels of inflammatory cytokines (IL-6, IL-10, TNFα) and cytokine balance (IL-6: IL-10, TNFα: IL-10) quantified with SIMOA, and cognitive performance with CogSport computer-based testing battery. These measures were repeated after a twelve-month interval. Increased workplace stress between testing intervals was associated to an increased cytokine imbalance (β = 0.447, p = .015) after controlling for age and gender. Increases in cytokine imbalance occurred in unison with decreases in attention (β = 0.516, p = .002), decision-making (β = 0.452, p = .009) and working memory (β = 0.492, p = .004). These preliminary findings suggest the underlying mechanisms linking workplace stress and reduced cognitive performance may be influenced by measures of low-grade inflammation and specifically a cytokine imbalance. Our findings suggest a measure of cytokine balance may explain the heterogenous findings in previous studies that have focussed solely on the association of workplace stress with pro-inflammatory cytokines. Future work is needed however, to provide a broader evidence-base for our claims to better inform designs to intervene in the higher workplace stress-poorer cognition relationship. |
| first_indexed | 2024-12-12T22:24:44Z |
| format | Article |
| id | doaj.art-fff6b85beabc4568af9fd19bf2c099bf |
| institution | Directory Open Access Journal |
| issn | 2666-4976 |
| language | English |
| last_indexed | 2024-12-12T22:24:44Z |
| publishDate | 2022-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Comprehensive Psychoneuroendocrinology |
| spelling | doaj.art-fff6b85beabc4568af9fd19bf2c099bf2022-12-22T00:09:49ZengElsevierComprehensive Psychoneuroendocrinology2666-49762022-05-0110100131Within subject rise in serum TNFα to IL-10 ratio is associated with poorer attention, decision-making and working memory in jockeysStefan Piantella0William T. O'Brien1Matthew W. Hale2Paul Maruff3Stuart J. McDonald4Bradley J. Wright5Department of Psychology and Counselling, La Trobe University, Melbourne, VIC, AustraliaDepartment of Neuroscience, Central Clinical School, Monash University, Melbourne, VIC, AustraliaDepartment of Psychology and Counselling, La Trobe University, Melbourne, VIC, AustraliaThe Florey Institute, The University of Melbourne, Melbourne, VIC, AustraliaDepartment of Neuroscience, Central Clinical School, Monash University, Melbourne, VIC, AustraliaDepartment of Psychology and Counselling, La Trobe University, Melbourne, VIC, Australia; Corresponding author. School of Psychology and Public Health, La Trobe University, Melbourne, VIC, Australia.Jockeys work in high-risk environments that rely heavily on attention- and decision-making to perform well and safely. Workplace stress literature has often overlooked the impact of stress on cognition, and designs that include physiological measures are rare. This study assessed the prospective concurrent relationships between workplace stress, depression symptoms and low-grade inflammation with cognitive performance among professional jockeys. Professional jockeys (N = 35, Mage = 32.29) provided information on workplace stress and depression symptoms, with serum levels of inflammatory cytokines (IL-6, IL-10, TNFα) and cytokine balance (IL-6: IL-10, TNFα: IL-10) quantified with SIMOA, and cognitive performance with CogSport computer-based testing battery. These measures were repeated after a twelve-month interval. Increased workplace stress between testing intervals was associated to an increased cytokine imbalance (β = 0.447, p = .015) after controlling for age and gender. Increases in cytokine imbalance occurred in unison with decreases in attention (β = 0.516, p = .002), decision-making (β = 0.452, p = .009) and working memory (β = 0.492, p = .004). These preliminary findings suggest the underlying mechanisms linking workplace stress and reduced cognitive performance may be influenced by measures of low-grade inflammation and specifically a cytokine imbalance. Our findings suggest a measure of cytokine balance may explain the heterogenous findings in previous studies that have focussed solely on the association of workplace stress with pro-inflammatory cytokines. Future work is needed however, to provide a broader evidence-base for our claims to better inform designs to intervene in the higher workplace stress-poorer cognition relationship.http://www.sciencedirect.com/science/article/pii/S2666497622000224Effort-reward imbalanceInflammationCognitionLongitudinalCRPCogSport |
| spellingShingle | Stefan Piantella William T. O'Brien Matthew W. Hale Paul Maruff Stuart J. McDonald Bradley J. Wright Within subject rise in serum TNFα to IL-10 ratio is associated with poorer attention, decision-making and working memory in jockeys Comprehensive Psychoneuroendocrinology Effort-reward imbalance Inflammation Cognition Longitudinal CRP CogSport |
| title | Within subject rise in serum TNFα to IL-10 ratio is associated with poorer attention, decision-making and working memory in jockeys |
| title_full | Within subject rise in serum TNFα to IL-10 ratio is associated with poorer attention, decision-making and working memory in jockeys |
| title_fullStr | Within subject rise in serum TNFα to IL-10 ratio is associated with poorer attention, decision-making and working memory in jockeys |
| title_full_unstemmed | Within subject rise in serum TNFα to IL-10 ratio is associated with poorer attention, decision-making and working memory in jockeys |
| title_short | Within subject rise in serum TNFα to IL-10 ratio is associated with poorer attention, decision-making and working memory in jockeys |
| title_sort | within subject rise in serum tnfα to il 10 ratio is associated with poorer attention decision making and working memory in jockeys |
| topic | Effort-reward imbalance Inflammation Cognition Longitudinal CRP CogSport |
| url | http://www.sciencedirect.com/science/article/pii/S2666497622000224 |
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