Histopathological effects of intramuscular metamizole sodium on rat sciatic nerve
Objective(s): We investigated the histopathological effects of metamizole sodium (MS) on the sciatic nerve. Materials and Methods: This study was performed using 48 adult male Wistar albino rats. Ten groups were constituted with 6 rats in each group. MS injection into the sciatic nerve (group 1), M...
| Main Authors: | , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Mashhad University of Medical Sciences
2016-08-01
|
| Series: | Iranian Journal of Basic Medical Sciences |
| Subjects: | |
| Online Access: | http://ijbms.mums.ac.ir/article_7463_283eaf5cd5eec9688b21f0aba98ea54a.pdf |
| _version_ | 1811283039008849920 |
|---|---|
| author | Abdurrahman Emir Yıldıray Kalkan Habib Bostan |
| author_facet | Abdurrahman Emir Yıldıray Kalkan Habib Bostan |
| author_sort | Abdurrahman Emir |
| collection | DOAJ |
| description | Objective(s): We investigated the histopathological effects of metamizole sodium (MS) on the sciatic nerve. Materials and Methods: This study was performed using 48 adult male Wistar albino rats. Ten groups were constituted with 6 rats in each group. MS injection into the sciatic nerve (group 1), MS injection into the muscle [group 3 (50 mg/kg, 0.4 ml) and group 5 (50 mg/kg, 0.8 ml)], MS injection into the muscle cavity in the vicinity of the sciatic nerve [group 2 (50 mg/kg, 0.4 ml) and group 4 (50 mg/kg, 0.8 ml)], normal saline injection into the muscle in the vicinity of the sciatic nerve [group 6A (0.4 ml) and 6B (0.8 ml)], subjected to injury by drilling the entire layer of nerve without injecting any drug, normal saline injection in the sciatic nerve, and control group. Nerve and muscle samples were taken 7 days after administrations. Tissue sections were stained using a hematoxylin and eosin-Luxol® fast blue stain, assessed by a histologist. Results: The levels of axonal degeneration of the rats in groups 1, 2, 3, 4, 5, 6A, and 8 were found to be significantly higher compared to the levels of the rats in the control group (P |
| first_indexed | 2024-04-13T02:03:22Z |
| format | Article |
| id | doaj.art-fff7378b9ce24d3ea0a021e24fa1a2e2 |
| institution | Directory Open Access Journal |
| issn | 2008-3866 2008-3874 |
| language | English |
| last_indexed | 2024-04-13T02:03:22Z |
| publishDate | 2016-08-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Basic Medical Sciences |
| spelling | doaj.art-fff7378b9ce24d3ea0a021e24fa1a2e22022-12-22T03:07:33ZengMashhad University of Medical SciencesIranian Journal of Basic Medical Sciences2008-38662008-38742016-08-0119882983610.22038/ijbms.2016.74637463Histopathological effects of intramuscular metamizole sodium on rat sciatic nerveAbdurrahman Emir0Yıldıray Kalkan1Habib Bostan2Bitlis Branch Directorate, Council of Forensic Medicine, The Ministry of Justice, Bitlis, TurkeyDepartment of Histology, Medical Faculty, Recep Tayyip Erdoğan University, Rize, TurkeyThe Ministry of Justice, Council of Forensic Medicine, Istanbul, TurkeyObjective(s): We investigated the histopathological effects of metamizole sodium (MS) on the sciatic nerve. Materials and Methods: This study was performed using 48 adult male Wistar albino rats. Ten groups were constituted with 6 rats in each group. MS injection into the sciatic nerve (group 1), MS injection into the muscle [group 3 (50 mg/kg, 0.4 ml) and group 5 (50 mg/kg, 0.8 ml)], MS injection into the muscle cavity in the vicinity of the sciatic nerve [group 2 (50 mg/kg, 0.4 ml) and group 4 (50 mg/kg, 0.8 ml)], normal saline injection into the muscle in the vicinity of the sciatic nerve [group 6A (0.4 ml) and 6B (0.8 ml)], subjected to injury by drilling the entire layer of nerve without injecting any drug, normal saline injection in the sciatic nerve, and control group. Nerve and muscle samples were taken 7 days after administrations. Tissue sections were stained using a hematoxylin and eosin-Luxol® fast blue stain, assessed by a histologist. Results: The levels of axonal degeneration of the rats in groups 1, 2, 3, 4, 5, 6A, and 8 were found to be significantly higher compared to the levels of the rats in the control group (Phttp://ijbms.mums.ac.ir/article_7463_283eaf5cd5eec9688b21f0aba98ea54a.pdfHistopathologyMetamizoleRatSciatic nerve |
| spellingShingle | Abdurrahman Emir Yıldıray Kalkan Habib Bostan Histopathological effects of intramuscular metamizole sodium on rat sciatic nerve Iranian Journal of Basic Medical Sciences Histopathology Metamizole Rat Sciatic nerve |
| title | Histopathological effects of intramuscular metamizole sodium on rat sciatic nerve |
| title_full | Histopathological effects of intramuscular metamizole sodium on rat sciatic nerve |
| title_fullStr | Histopathological effects of intramuscular metamizole sodium on rat sciatic nerve |
| title_full_unstemmed | Histopathological effects of intramuscular metamizole sodium on rat sciatic nerve |
| title_short | Histopathological effects of intramuscular metamizole sodium on rat sciatic nerve |
| title_sort | histopathological effects of intramuscular metamizole sodium on rat sciatic nerve |
| topic | Histopathology Metamizole Rat Sciatic nerve |
| url | http://ijbms.mums.ac.ir/article_7463_283eaf5cd5eec9688b21f0aba98ea54a.pdf |
| work_keys_str_mv | AT abdurrahmanemir histopathologicaleffectsofintramuscularmetamizolesodiumonratsciaticnerve AT yıldıraykalkan histopathologicaleffectsofintramuscularmetamizolesodiumonratsciaticnerve AT habibbostan histopathologicaleffectsofintramuscularmetamizolesodiumonratsciaticnerve |