Facile construction of gold- and BODIPY-coordinated liposomal nanocomplexes for enhanced photothermal therapy of cancer
Photothermal therapy (PTT) has attracted extensive attention in cancer treatment because of its advantages of non-invasive and few side effects. Gold nanoparticles and boron-fluorine-dipyrrole (BODIPY) dye have been used as photothermal agents (PTAs), but they have problems such as easy aggregation,...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-05-01
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| Series: | Materials & Design |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S0264127524002685 |
| _version_ | 1797216000388628480 |
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| author | Yuran Wang Xudong Li Ya Wang Haijun Chen Yu Gao Yuxiang Lin |
| author_facet | Yuran Wang Xudong Li Ya Wang Haijun Chen Yu Gao Yuxiang Lin |
| author_sort | Yuran Wang |
| collection | DOAJ |
| description | Photothermal therapy (PTT) has attracted extensive attention in cancer treatment because of its advantages of non-invasive and few side effects. Gold nanoparticles and boron-fluorine-dipyrrole (BODIPY) dye have been used as photothermal agents (PTAs), but they have problems such as easy aggregation, poor water solubility and low photothermal conversion efficiency. In this work, we used conventional liposomes for in situ generation of small gold nanoparticles and sequentially loading BODIPY to overcome the drawbacks of the two PTAs and simultaneously realize enhanced PTT. Gold- and BODIPY-coordinated liposomal nanocomplexes LAB with small gold nanoparticles adsorbed on the surface and BODIPY entrapped inside showed uniform size of about 100 nm with good stability. LAB demonstrated laser-responsive drug release property, good cellular uptake efficiency and tumor accumulation ability. After laser irradiation, LAB can exert enhanced PTT in cancer cell lines by reducing mitochondrial membrane potential and increase intracellular reactive oxygen species level to promote cell apoptosis. In tumor-bearing mice, LAB showed fantastic tumor inhibition effect with good biosafety. This work provides a convenient method to develop PTA combinations for enhanced PTT, which could lay the foundation for the green construction of new PTAs for PTT by employing clinically used formulations and PTAs. |
| first_indexed | 2024-04-24T11:39:00Z |
| format | Article |
| id | doaj.art-fff8db61afa84ae8ba441136f0523497 |
| institution | Directory Open Access Journal |
| issn | 0264-1275 |
| language | English |
| last_indexed | 2024-04-24T11:39:00Z |
| publishDate | 2024-05-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials & Design |
| spelling | doaj.art-fff8db61afa84ae8ba441136f05234972024-04-10T04:28:29ZengElsevierMaterials & Design0264-12752024-05-01241112895Facile construction of gold- and BODIPY-coordinated liposomal nanocomplexes for enhanced photothermal therapy of cancerYuran Wang0Xudong Li1Ya Wang2Haijun Chen3Yu Gao4Yuxiang Lin5Department of Breast Surgery, Fujian Medical University Union Hospital, Fuzhou 350001, Fujian, China; Cancer Metastasis Alert and Prevention Centre, College of Chemistry, and Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy, Fuzhou University, Fuzhou 350108, ChinaCancer Metastasis Alert and Prevention Centre, College of Chemistry, and Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy, Fuzhou University, Fuzhou 350108, ChinaCancer Metastasis Alert and Prevention Centre, College of Chemistry, and Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy, Fuzhou University, Fuzhou 350108, ChinaKey Laboratory of Molecule Synthesis and Function Discovery (Fujian Province University), College of Chemistry, Fuzhou University, Fuzhou, Fujian 350116, ChinaCancer Metastasis Alert and Prevention Centre, College of Chemistry, and Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy, Fuzhou University, Fuzhou 350108, China; Corresponding authors at: Department of Breast Surgery, Fujian Medical University Union Hospital, Fuzhou, 350001, Fujian, China (Yuxiang Lin); Cancer Metastasis Alert and Prevention Centre, College of Chemistry, and Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy, Fuzhou University, Fuzhou 350108, China (Yu Gao).Department of Breast Surgery, Fujian Medical University Union Hospital, Fuzhou 350001, Fujian, China; Department of General Surgery, Fujian Medical University Union Hospital, Fuzhou 350001, Fujian, China; Breast Cancer Institute, Fujian Medical University, Fuzhou 350001, Fujian, China; Corresponding authors at: Department of Breast Surgery, Fujian Medical University Union Hospital, Fuzhou, 350001, Fujian, China (Yuxiang Lin); Cancer Metastasis Alert and Prevention Centre, College of Chemistry, and Fujian Provincial Key Laboratory of Cancer Metastasis Chemoprevention and Chemotherapy, Fuzhou University, Fuzhou 350108, China (Yu Gao).Photothermal therapy (PTT) has attracted extensive attention in cancer treatment because of its advantages of non-invasive and few side effects. Gold nanoparticles and boron-fluorine-dipyrrole (BODIPY) dye have been used as photothermal agents (PTAs), but they have problems such as easy aggregation, poor water solubility and low photothermal conversion efficiency. In this work, we used conventional liposomes for in situ generation of small gold nanoparticles and sequentially loading BODIPY to overcome the drawbacks of the two PTAs and simultaneously realize enhanced PTT. Gold- and BODIPY-coordinated liposomal nanocomplexes LAB with small gold nanoparticles adsorbed on the surface and BODIPY entrapped inside showed uniform size of about 100 nm with good stability. LAB demonstrated laser-responsive drug release property, good cellular uptake efficiency and tumor accumulation ability. After laser irradiation, LAB can exert enhanced PTT in cancer cell lines by reducing mitochondrial membrane potential and increase intracellular reactive oxygen species level to promote cell apoptosis. In tumor-bearing mice, LAB showed fantastic tumor inhibition effect with good biosafety. This work provides a convenient method to develop PTA combinations for enhanced PTT, which could lay the foundation for the green construction of new PTAs for PTT by employing clinically used formulations and PTAs.http://www.sciencedirect.com/science/article/pii/S0264127524002685BODIPYGold nanoparticlesLipid nanocomplexesAnti-tumorSynergistic photothermal therapy |
| spellingShingle | Yuran Wang Xudong Li Ya Wang Haijun Chen Yu Gao Yuxiang Lin Facile construction of gold- and BODIPY-coordinated liposomal nanocomplexes for enhanced photothermal therapy of cancer Materials & Design BODIPY Gold nanoparticles Lipid nanocomplexes Anti-tumor Synergistic photothermal therapy |
| title | Facile construction of gold- and BODIPY-coordinated liposomal nanocomplexes for enhanced photothermal therapy of cancer |
| title_full | Facile construction of gold- and BODIPY-coordinated liposomal nanocomplexes for enhanced photothermal therapy of cancer |
| title_fullStr | Facile construction of gold- and BODIPY-coordinated liposomal nanocomplexes for enhanced photothermal therapy of cancer |
| title_full_unstemmed | Facile construction of gold- and BODIPY-coordinated liposomal nanocomplexes for enhanced photothermal therapy of cancer |
| title_short | Facile construction of gold- and BODIPY-coordinated liposomal nanocomplexes for enhanced photothermal therapy of cancer |
| title_sort | facile construction of gold and bodipy coordinated liposomal nanocomplexes for enhanced photothermal therapy of cancer |
| topic | BODIPY Gold nanoparticles Lipid nanocomplexes Anti-tumor Synergistic photothermal therapy |
| url | http://www.sciencedirect.com/science/article/pii/S0264127524002685 |
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