Cellular and molecular aspects at invasive tumor front in oral squamous cell carcinoma (Part-II)
Oral squamous cell carcinoma (OSCC) is the most prevalent malignant cancer in the oral cavity. Despite considerable advances in diagnostic and therapeutic field, its prognosis remains poor. Grading by histopathological features does not influence prognosis until deeply invasive margins are evaluated...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2016-01-01
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| Series: | SRM Journal of Research in Dental Sciences |
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| Online Access: | http://www.srmjrds.in/article.asp?issn=0976-433X;year=2016;volume=7;issue=4;spage=235;epage=241;aulast=Chaudhari |
| _version_ | 1811291670137798656 |
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| author | Rekha Bhaskar Chaudhari |
| author_facet | Rekha Bhaskar Chaudhari |
| author_sort | Rekha Bhaskar Chaudhari |
| collection | DOAJ |
| description | Oral squamous cell carcinoma (OSCC) is the most prevalent malignant cancer in the oral cavity. Despite considerable advances in diagnostic and therapeutic field, its prognosis remains poor. Grading by histopathological features does not influence prognosis until deeply invasive margins are evaluated by pathologists. The most invasive part of malignant tumor reflects disturbance in molecular mechanism, alteration in gene expression that controls cell differentiation, growth, death (apoptosis) as well as interactions between cancer cells and stromal components that may lead to the formation of oncofetal extracellular matrix, enabling tumor cell phenotype transition and migration. In recent years, analysis of cell proliferation, DNA content, and epithelial-mesenchymal transition (EMT) phenomenon has been used in an attempt to identify new prognostic indicators. Great interest is also shown in matrix metalloproteinase which plays a key role in invasion and metastasis. This review focuses on altered pathways in OSCC at gene expression and protein level, role of proteinases and EMT phenomenon in tumor progression, invasion, and metastasis with respect to invasive tumor front. |
| first_indexed | 2024-04-13T04:32:51Z |
| format | Article |
| id | doaj.art-fff95446f2534386965285738c588d83 |
| institution | Directory Open Access Journal |
| issn | 2772-5243 2772-5251 |
| language | English |
| last_indexed | 2024-04-13T04:32:51Z |
| publishDate | 2016-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | SRM Journal of Research in Dental Sciences |
| spelling | doaj.art-fff95446f2534386965285738c588d832022-12-22T03:02:16ZengWolters Kluwer Medknow PublicationsSRM Journal of Research in Dental Sciences2772-52432772-52512016-01-017423524110.4103/0976-433X.195635Cellular and molecular aspects at invasive tumor front in oral squamous cell carcinoma (Part-II)Rekha Bhaskar ChaudhariOral squamous cell carcinoma (OSCC) is the most prevalent malignant cancer in the oral cavity. Despite considerable advances in diagnostic and therapeutic field, its prognosis remains poor. Grading by histopathological features does not influence prognosis until deeply invasive margins are evaluated by pathologists. The most invasive part of malignant tumor reflects disturbance in molecular mechanism, alteration in gene expression that controls cell differentiation, growth, death (apoptosis) as well as interactions between cancer cells and stromal components that may lead to the formation of oncofetal extracellular matrix, enabling tumor cell phenotype transition and migration. In recent years, analysis of cell proliferation, DNA content, and epithelial-mesenchymal transition (EMT) phenomenon has been used in an attempt to identify new prognostic indicators. Great interest is also shown in matrix metalloproteinase which plays a key role in invasion and metastasis. This review focuses on altered pathways in OSCC at gene expression and protein level, role of proteinases and EMT phenomenon in tumor progression, invasion, and metastasis with respect to invasive tumor front.http://www.srmjrds.in/article.asp?issn=0976-433X;year=2016;volume=7;issue=4;spage=235;epage=241;aulast=Chaudharigenetic markersmatrix metalloproteinasesmolecular factorsoral squamous cell carcinomatumor budding and epithelial-mesenchymal transition |
| spellingShingle | Rekha Bhaskar Chaudhari Cellular and molecular aspects at invasive tumor front in oral squamous cell carcinoma (Part-II) SRM Journal of Research in Dental Sciences genetic markers matrix metalloproteinases molecular factors oral squamous cell carcinoma tumor budding and epithelial-mesenchymal transition |
| title | Cellular and molecular aspects at invasive tumor front in oral squamous cell carcinoma (Part-II) |
| title_full | Cellular and molecular aspects at invasive tumor front in oral squamous cell carcinoma (Part-II) |
| title_fullStr | Cellular and molecular aspects at invasive tumor front in oral squamous cell carcinoma (Part-II) |
| title_full_unstemmed | Cellular and molecular aspects at invasive tumor front in oral squamous cell carcinoma (Part-II) |
| title_short | Cellular and molecular aspects at invasive tumor front in oral squamous cell carcinoma (Part-II) |
| title_sort | cellular and molecular aspects at invasive tumor front in oral squamous cell carcinoma part ii |
| topic | genetic markers matrix metalloproteinases molecular factors oral squamous cell carcinoma tumor budding and epithelial-mesenchymal transition |
| url | http://www.srmjrds.in/article.asp?issn=0976-433X;year=2016;volume=7;issue=4;spage=235;epage=241;aulast=Chaudhari |
| work_keys_str_mv | AT rekhabhaskarchaudhari cellularandmolecularaspectsatinvasivetumorfrontinoralsquamouscellcarcinomapartii |