Biomimetic design of bioartificial scaffolds for the in vitro modelling of human cardiac fibrosis

Biomimetic design of bioartificial scaffolds for the in vitro modelling of human cardiac fibrosis

In vitro models of pathological cardiac tissue have attracted interest as predictive platforms for preclinical validation of therapies. However, models reproducing specific pathological features, such as cardiac fibrosis size (i.e., thickness and width) and stage of development are missing. This res...

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Bibliographic Details
Main Authors: Mattia Spedicati, Gerardina Ruocco, Alice Zoso, Leonardo Mortati, Andrea Lapini, Andrea Delledonne, Carla Divieto, Veronica Romano, Clotilde Castaldo, Franca Di Meglio, Daria Nurzynska, Irene Carmagnola, Valeria Chiono
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-11-01
Series:Frontiers in Bioengineering and Biotechnology
Subjects:
bioartificial scaffold
cardiac fibrosis
in vitro model
poly(caprolactone)
gelatin
extracellular matrix
Online Access:https://www.frontiersin.org/articles/10.3389/fbioe.2022.983872/full

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