Polyglutamine induced misfolding of huntingtin exon1 is modulated by the flanking sequences.

Polyglutamine induced misfolding of huntingtin exon1 is modulated by the flanking sequences.

Polyglutamine (polyQ) expansion in exon1 (XN1) of the huntingtin protein is linked to Huntington's disease. When the number of glutamines exceeds a threshold of approximately 36-40 repeats, XN1 can readily form amyloid aggregates similar to those associated with disease. Many experiments sugges...

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Bibliographic Details
Main Authors:	Vinal V Lakhani, Feng Ding, Nikolay V Dokholyan
Format:	Article
Language:	English
Published:	Public Library of Science (PLoS) 2010-04-01
Series:	PLoS Computational Biology
Online Access:	http://europepmc.org/articles/PMC2861695?pdf=render

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