Stress, genomic adaptation, and the evolutionary trade-off
Cells are constantly exposed to various internal and external stresses. The importance of cellular stress and its implication to disease conditions have become popular research topics. Many ongoing investigations focus on the sources of stress, their specific molecular mechanisms and interactions, e...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2014-04-01
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| Series: | Frontiers in Genetics |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fgene.2014.00092/full |
| _version_ | 1818063855040856064 |
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| author | Steven D. Horne Saroj K. Chowdhury Henry HQ Heng Henry HQ Heng |
| author_facet | Steven D. Horne Saroj K. Chowdhury Henry HQ Heng Henry HQ Heng |
| author_sort | Steven D. Horne |
| collection | DOAJ |
| description | Cells are constantly exposed to various internal and external stresses. The importance of cellular stress and its implication to disease conditions have become popular research topics. Many ongoing investigations focus on the sources of stress, their specific molecular mechanisms and interactions, especially regarding their contributions to many common and complex diseases through defined molecular pathways. Numerous molecular mechanisms have been linked to ER stress along with many unexpected findings, drastically increasing the complexity of our molecular understanding and challenging how to apply individual mechanism-based knowledge in the clinic. A newly emergent genome theory searches for the synthesis of a general evolutionary mechanism that unifies different types of stress and functional relationships from a genome-defined system point of view. Herein, we discuss the evolutionary relationship between stress and somatic cell adaptation under physiological, pathological, and somatic cell survival conditions, the multiple meanings to achieve adaptation and its potential trade-off. In particular, we purposely defocus from specific stresses and mechanisms by redirecting attention towards studying underlying general mechanisms. |
| first_indexed | 2024-12-10T14:26:44Z |
| format | Article |
| id | doaj.art-fffa29b398604d3c88435f5b686fe12e |
| institution | Directory Open Access Journal |
| issn | 1664-8021 |
| language | English |
| last_indexed | 2024-12-10T14:26:44Z |
| publishDate | 2014-04-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Genetics |
| spelling | doaj.art-fffa29b398604d3c88435f5b686fe12e2022-12-22T01:45:03ZengFrontiers Media S.A.Frontiers in Genetics1664-80212014-04-01510.3389/fgene.2014.0009288292Stress, genomic adaptation, and the evolutionary trade-offSteven D. Horne0Saroj K. Chowdhury1Henry HQ Heng2Henry HQ Heng3Wayne State University School of MedicineJohn D. Dingell VA Medical CenterWayne State University School of MedicineWayne State University School of MedicineCells are constantly exposed to various internal and external stresses. The importance of cellular stress and its implication to disease conditions have become popular research topics. Many ongoing investigations focus on the sources of stress, their specific molecular mechanisms and interactions, especially regarding their contributions to many common and complex diseases through defined molecular pathways. Numerous molecular mechanisms have been linked to ER stress along with many unexpected findings, drastically increasing the complexity of our molecular understanding and challenging how to apply individual mechanism-based knowledge in the clinic. A newly emergent genome theory searches for the synthesis of a general evolutionary mechanism that unifies different types of stress and functional relationships from a genome-defined system point of view. Herein, we discuss the evolutionary relationship between stress and somatic cell adaptation under physiological, pathological, and somatic cell survival conditions, the multiple meanings to achieve adaptation and its potential trade-off. In particular, we purposely defocus from specific stresses and mechanisms by redirecting attention towards studying underlying general mechanisms.http://journal.frontiersin.org/Journal/10.3389/fgene.2014.00092/fullChromosomal Instabilitystress responsegenome instabilityGenome theorySomatic evolution |
| spellingShingle | Steven D. Horne Saroj K. Chowdhury Henry HQ Heng Henry HQ Heng Stress, genomic adaptation, and the evolutionary trade-off Frontiers in Genetics Chromosomal Instability stress response genome instability Genome theory Somatic evolution |
| title | Stress, genomic adaptation, and the evolutionary trade-off |
| title_full | Stress, genomic adaptation, and the evolutionary trade-off |
| title_fullStr | Stress, genomic adaptation, and the evolutionary trade-off |
| title_full_unstemmed | Stress, genomic adaptation, and the evolutionary trade-off |
| title_short | Stress, genomic adaptation, and the evolutionary trade-off |
| title_sort | stress genomic adaptation and the evolutionary trade off |
| topic | Chromosomal Instability stress response genome instability Genome theory Somatic evolution |
| url | http://journal.frontiersin.org/Journal/10.3389/fgene.2014.00092/full |
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