Polyphenols from the Mediterranean herb rosemary (Rosmarinus officinalis) for prostate cancer
The Mediterranean diet is rich in fruits and vegetables and has been associated with a variety of health benefits including cancer prevention. One aspect of the diet that has not received enough attention is Mediterranean herbs. Specifically, rosemary and its polyphenolic diterpenes (carnosic acid...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2013-03-01
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| Series: | Frontiers in Pharmacology |
| Subjects: | |
| Online Access: | http://journal.frontiersin.org/Journal/10.3389/fphar.2013.00029/full |
| _version_ | 1828810230290448384 |
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| author | Sakina M Petiwala Angela G Puthenveetil Jeremy eJohnson Jeremy eJohnson |
| author_facet | Sakina M Petiwala Angela G Puthenveetil Jeremy eJohnson Jeremy eJohnson |
| author_sort | Sakina M Petiwala |
| collection | DOAJ |
| description | The Mediterranean diet is rich in fruits and vegetables and has been associated with a variety of health benefits including cancer prevention. One aspect of the diet that has not received enough attention is Mediterranean herbs. Specifically, rosemary and its polyphenolic diterpenes (carnosic acid and carnosol) are known to possess antioxidant activity that may be beneficial for cancer control. Herein, we describe the in vitro and in vivo studies carried out towards understanding the molecular mechanisms of carnosic acid and carnosol leading to inhibition of prostate cancer. The reported findings suggest that these polyphenols target multiple signaling pathways involved in cell cycle modulation and apoptosis. Further work is required to understand its potential for health promotion and potential drug discovery for prostate cancer chemoprevention. |
| first_indexed | 2024-12-12T09:08:44Z |
| format | Article |
| id | doaj.art-fffb9294d2814bf2819c1098f3ad8a8d |
| institution | Directory Open Access Journal |
| issn | 1663-9812 |
| language | English |
| last_indexed | 2024-12-12T09:08:44Z |
| publishDate | 2013-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Pharmacology |
| spelling | doaj.art-fffb9294d2814bf2819c1098f3ad8a8d2022-12-22T00:29:35ZengFrontiers Media S.A.Frontiers in Pharmacology1663-98122013-03-01410.3389/fphar.2013.0002942634Polyphenols from the Mediterranean herb rosemary (Rosmarinus officinalis) for prostate cancerSakina M Petiwala0Angela G Puthenveetil1Jeremy eJohnson2Jeremy eJohnson3University of Illinois at Chicago - College of PharmacyUniversity of Illinois at Chicago - College of PharmacyUniversity of Illinois at Chicago - College of PharmacyUniversity of Illinois Cancer CenterThe Mediterranean diet is rich in fruits and vegetables and has been associated with a variety of health benefits including cancer prevention. One aspect of the diet that has not received enough attention is Mediterranean herbs. Specifically, rosemary and its polyphenolic diterpenes (carnosic acid and carnosol) are known to possess antioxidant activity that may be beneficial for cancer control. Herein, we describe the in vitro and in vivo studies carried out towards understanding the molecular mechanisms of carnosic acid and carnosol leading to inhibition of prostate cancer. The reported findings suggest that these polyphenols target multiple signaling pathways involved in cell cycle modulation and apoptosis. Further work is required to understand its potential for health promotion and potential drug discovery for prostate cancer chemoprevention.http://journal.frontiersin.org/Journal/10.3389/fphar.2013.00029/fullDiterpenesprostate cancercarnosolcarnosic acidrosemary extract |
| spellingShingle | Sakina M Petiwala Angela G Puthenveetil Jeremy eJohnson Jeremy eJohnson Polyphenols from the Mediterranean herb rosemary (Rosmarinus officinalis) for prostate cancer Frontiers in Pharmacology Diterpenes prostate cancer carnosol carnosic acid rosemary extract |
| title | Polyphenols from the Mediterranean herb rosemary (Rosmarinus officinalis) for prostate cancer |
| title_full | Polyphenols from the Mediterranean herb rosemary (Rosmarinus officinalis) for prostate cancer |
| title_fullStr | Polyphenols from the Mediterranean herb rosemary (Rosmarinus officinalis) for prostate cancer |
| title_full_unstemmed | Polyphenols from the Mediterranean herb rosemary (Rosmarinus officinalis) for prostate cancer |
| title_short | Polyphenols from the Mediterranean herb rosemary (Rosmarinus officinalis) for prostate cancer |
| title_sort | polyphenols from the mediterranean herb rosemary rosmarinus officinalis for prostate cancer |
| topic | Diterpenes prostate cancer carnosol carnosic acid rosemary extract |
| url | http://journal.frontiersin.org/Journal/10.3389/fphar.2013.00029/full |
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