Disturbance of skin sensation and autism spectrum disorder: A bidirectional Mendelian randomization study
Abstract Background and aim Patients with autism spectrum disorder (ASD) commonly experience aberrant skin sensation sensitivity; however, the causal relationship is not yet clear. This study uses a bidirectional Mendelian randomization (MR) method to explore the relationship between disturbance of...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2023-11-01
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| Series: | Brain and Behavior |
| Subjects: | |
| Online Access: | https://doi.org/10.1002/brb3.3238 |
| _version_ | 1797632598686564352 |
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| author | Xiao Zhong Letong Wang Lin Xu Jie Lian Jie Chen Xinxin Gong Yongcong Shao |
| author_facet | Xiao Zhong Letong Wang Lin Xu Jie Lian Jie Chen Xinxin Gong Yongcong Shao |
| author_sort | Xiao Zhong |
| collection | DOAJ |
| description | Abstract Background and aim Patients with autism spectrum disorder (ASD) commonly experience aberrant skin sensation sensitivity; however, the causal relationship is not yet clear. This study uses a bidirectional Mendelian randomization (MR) method to explore the relationship between disturbance of skin sensation (DSS) and ASD. Methods Single‐nucleotide polymorphisms (SNPs) extracted from the summary data of genome‐wide association studies were used as genetic instruments. MR was performed using the inverse‐variance‐weighted method, with alternate methods (e.g., weighted median, MR‐Egger, simple mode, weighted mode, and MR‐pleiotropy residual sum and outlier) and multiple sensitivity analyses to assess horizontal pleiotropy and remove outliers. Results The results of the analysis using six SNPs as genetic instruments showed that the DSS is associated with an increased risk of ASD (odds ratio = 1.126, 95% confidence interval = 1.029–1.132; p = .010). The results of the sensitivity analyses were robust with no evidence of pleiotropy. The reverse MR analyses showed no causal effects of ASD on DSS. Conclusion This study's findings suggest that DSS has potential causal effects on ASD, whereas ASD has no effect on DSS. Thus, skin sensitivity may represent a behavioral marker of ASD, by which some populations could be subtyped in the future. |
| first_indexed | 2024-03-11T11:40:08Z |
| format | Article |
| id | doaj.art-fffc8afd896945519119b3200d093992 |
| institution | Directory Open Access Journal |
| issn | 2162-3279 |
| language | English |
| last_indexed | 2024-03-11T11:40:08Z |
| publishDate | 2023-11-01 |
| publisher | Wiley |
| record_format | Article |
| series | Brain and Behavior |
| spelling | doaj.art-fffc8afd896945519119b3200d0939922023-11-10T06:53:59ZengWileyBrain and Behavior2162-32792023-11-011311n/an/a10.1002/brb3.3238Disturbance of skin sensation and autism spectrum disorder: A bidirectional Mendelian randomization studyXiao Zhong0Letong Wang1Lin Xu2Jie Lian3Jie Chen4Xinxin Gong5Yongcong Shao6School of Psychology Beijing Sport University Beijing ChinaSchool of Psychology Beijing Sport University Beijing ChinaSchool of Psychology Beijing Sport University Beijing ChinaSchool of Psychology Beijing Sport University Beijing ChinaSchool of Psychology Beijing Sport University Beijing ChinaSchool of Psychology Beijing Sport University Beijing ChinaSchool of Psychology Beijing Sport University Beijing ChinaAbstract Background and aim Patients with autism spectrum disorder (ASD) commonly experience aberrant skin sensation sensitivity; however, the causal relationship is not yet clear. This study uses a bidirectional Mendelian randomization (MR) method to explore the relationship between disturbance of skin sensation (DSS) and ASD. Methods Single‐nucleotide polymorphisms (SNPs) extracted from the summary data of genome‐wide association studies were used as genetic instruments. MR was performed using the inverse‐variance‐weighted method, with alternate methods (e.g., weighted median, MR‐Egger, simple mode, weighted mode, and MR‐pleiotropy residual sum and outlier) and multiple sensitivity analyses to assess horizontal pleiotropy and remove outliers. Results The results of the analysis using six SNPs as genetic instruments showed that the DSS is associated with an increased risk of ASD (odds ratio = 1.126, 95% confidence interval = 1.029–1.132; p = .010). The results of the sensitivity analyses were robust with no evidence of pleiotropy. The reverse MR analyses showed no causal effects of ASD on DSS. Conclusion This study's findings suggest that DSS has potential causal effects on ASD, whereas ASD has no effect on DSS. Thus, skin sensitivity may represent a behavioral marker of ASD, by which some populations could be subtyped in the future.https://doi.org/10.1002/brb3.3238autism spectrum disorderdisturbance of skin sensationMendelian randomization |
| spellingShingle | Xiao Zhong Letong Wang Lin Xu Jie Lian Jie Chen Xinxin Gong Yongcong Shao Disturbance of skin sensation and autism spectrum disorder: A bidirectional Mendelian randomization study Brain and Behavior autism spectrum disorder disturbance of skin sensation Mendelian randomization |
| title | Disturbance of skin sensation and autism spectrum disorder: A bidirectional Mendelian randomization study |
| title_full | Disturbance of skin sensation and autism spectrum disorder: A bidirectional Mendelian randomization study |
| title_fullStr | Disturbance of skin sensation and autism spectrum disorder: A bidirectional Mendelian randomization study |
| title_full_unstemmed | Disturbance of skin sensation and autism spectrum disorder: A bidirectional Mendelian randomization study |
| title_short | Disturbance of skin sensation and autism spectrum disorder: A bidirectional Mendelian randomization study |
| title_sort | disturbance of skin sensation and autism spectrum disorder a bidirectional mendelian randomization study |
| topic | autism spectrum disorder disturbance of skin sensation Mendelian randomization |
| url | https://doi.org/10.1002/brb3.3238 |
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