Bimodal Nd-Doped LuVO<sub>4</sub> Nanoprobes Functionalized with Polyacrilic Acid for X-Ray Computed Tomography and NIR Luminescent Imaging
Uniform Nd<sup>3+</sup>-doped LuVO<sub>4</sub> nanophosphors have been synthesized for the first time in literature by using a poliol-based method at 120 °C from Nd<sup>3+</sup> and vanadate precursors. After optimizing the Nd doping level, these phosphor...
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MDPI AG
2020-01-01
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| Series: | Nanomaterials |
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| Online Access: | https://www.mdpi.com/2079-4991/10/1/149 |
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| author | Nuria O Nuñez Fernando Cussó Eugenio Cantelar Beatriz Martin-Gracia Jesús M de la Fuente Ariadna Corral Marcin Balcerzyk Manuel Ocaña |
| author_facet | Nuria O Nuñez Fernando Cussó Eugenio Cantelar Beatriz Martin-Gracia Jesús M de la Fuente Ariadna Corral Marcin Balcerzyk Manuel Ocaña |
| author_sort | Nuria O Nuñez |
| collection | DOAJ |
| description | Uniform Nd<sup>3+</sup>-doped LuVO<sub>4</sub> nanophosphors have been synthesized for the first time in literature by using a poliol-based method at 120 °C from Nd<sup>3+</sup> and vanadate precursors. After optimizing the Nd doping level, these phosphors present intense luminescence in the near-infrared biological windows. The X-ray attenuation capacity of the optimum nanophosphor has been found to be higher than that of a commercial X-ray computed tomography contrast agent. After surface coating with polyacrylic acid, such nanoparticles present high colloidal stability in physiological pH medium and high cell viability. Because of these properties, the developed Nd<sup>3+</sup>-doped LuVO<sub>4</sub> nanoparticles have potential applications as a bimodal probe for NIR luminescent bioimaging and X-ray computed tomography. |
| first_indexed | 2024-12-11T07:15:25Z |
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| institution | Directory Open Access Journal |
| issn | 2079-4991 |
| language | English |
| last_indexed | 2024-12-11T07:15:25Z |
| publishDate | 2020-01-01 |
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| series | Nanomaterials |
| spelling | doaj.art-fffeade6907d44fb9bf7e626d2be002b2022-12-22T01:16:14ZengMDPI AGNanomaterials2079-49912020-01-0110114910.3390/nano10010149nano10010149Bimodal Nd-Doped LuVO<sub>4</sub> Nanoprobes Functionalized with Polyacrilic Acid for X-Ray Computed Tomography and NIR Luminescent ImagingNuria O Nuñez0Fernando Cussó1Eugenio Cantelar2Beatriz Martin-Gracia3Jesús M de la Fuente4Ariadna Corral5Marcin Balcerzyk6Manuel Ocaña7Instituto de Ciencia de Materiales de Sevilla, CSIC-US, Américo Vespucio 49, Isla de la Cartuja, 41092 Sevilla, SpainDepartamento de Física de Materiales, C-04, Universidad Autónoma de Madrid, 28049 Madrid, SpainDepartamento de Física de Materiales, C-04, Universidad Autónoma de Madrid, 28049 Madrid, SpainInstituto de Ciencia de Materiales de Aragón, CSIC/UniZar and CIBER-BBN, Edificio I+D, Mariano Esquillor s/n, 50018 Zaragoza, SpainInstituto de Ciencia de Materiales de Aragón, CSIC/UniZar and CIBER-BBN, Edificio I+D, Mariano Esquillor s/n, 50018 Zaragoza, SpainCentro Nacional de Aceleradores (CNA) (Universidad de Sevilla, Junta de Andalucía, CSIC), c/Thomas Alva Edison 7, Isla de la Cartuja, 41092 Sevilla, SpainCentro Nacional de Aceleradores (CNA) (Universidad de Sevilla, Junta de Andalucía, CSIC), c/Thomas Alva Edison 7, Isla de la Cartuja, 41092 Sevilla, SpainInstituto de Ciencia de Materiales de Sevilla, CSIC-US, Américo Vespucio 49, Isla de la Cartuja, 41092 Sevilla, SpainUniform Nd<sup>3+</sup>-doped LuVO<sub>4</sub> nanophosphors have been synthesized for the first time in literature by using a poliol-based method at 120 °C from Nd<sup>3+</sup> and vanadate precursors. After optimizing the Nd doping level, these phosphors present intense luminescence in the near-infrared biological windows. The X-ray attenuation capacity of the optimum nanophosphor has been found to be higher than that of a commercial X-ray computed tomography contrast agent. After surface coating with polyacrylic acid, such nanoparticles present high colloidal stability in physiological pH medium and high cell viability. Because of these properties, the developed Nd<sup>3+</sup>-doped LuVO<sub>4</sub> nanoparticles have potential applications as a bimodal probe for NIR luminescent bioimaging and X-ray computed tomography.https://www.mdpi.com/2079-4991/10/1/149nanoparticlesluvo<sub>4</sub>neodymiumpolyacrilic acidnir luminescencex-ray computed tomography |
| spellingShingle | Nuria O Nuñez Fernando Cussó Eugenio Cantelar Beatriz Martin-Gracia Jesús M de la Fuente Ariadna Corral Marcin Balcerzyk Manuel Ocaña Bimodal Nd-Doped LuVO<sub>4</sub> Nanoprobes Functionalized with Polyacrilic Acid for X-Ray Computed Tomography and NIR Luminescent Imaging Nanomaterials nanoparticles luvo<sub>4</sub> neodymium polyacrilic acid nir luminescence x-ray computed tomography |
| title | Bimodal Nd-Doped LuVO<sub>4</sub> Nanoprobes Functionalized with Polyacrilic Acid for X-Ray Computed Tomography and NIR Luminescent Imaging |
| title_full | Bimodal Nd-Doped LuVO<sub>4</sub> Nanoprobes Functionalized with Polyacrilic Acid for X-Ray Computed Tomography and NIR Luminescent Imaging |
| title_fullStr | Bimodal Nd-Doped LuVO<sub>4</sub> Nanoprobes Functionalized with Polyacrilic Acid for X-Ray Computed Tomography and NIR Luminescent Imaging |
| title_full_unstemmed | Bimodal Nd-Doped LuVO<sub>4</sub> Nanoprobes Functionalized with Polyacrilic Acid for X-Ray Computed Tomography and NIR Luminescent Imaging |
| title_short | Bimodal Nd-Doped LuVO<sub>4</sub> Nanoprobes Functionalized with Polyacrilic Acid for X-Ray Computed Tomography and NIR Luminescent Imaging |
| title_sort | bimodal nd doped luvo sub 4 sub nanoprobes functionalized with polyacrilic acid for x ray computed tomography and nir luminescent imaging |
| topic | nanoparticles luvo<sub>4</sub> neodymium polyacrilic acid nir luminescence x-ray computed tomography |
| url | https://www.mdpi.com/2079-4991/10/1/149 |
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