Ultrahigh speed endoscopic swept source optical coherence tomography using a VCSEL light source and micromotor catheter
We developed an ultrahigh speed endoscopic swept source optical coherence tomography (OCT) system for clinical gastroenterology using a vertical-cavity surface-emitting laser (VCSEL) and micromotor based imaging catheter, which provided an imaging speed of 600 kHz axial scan rate and 8 μm axial reso...
| Main Authors: | , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | en_US |
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SPIE
2015
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| Online Access: | http://hdl.handle.net/1721.1/100219 https://orcid.org/0000-0003-4811-3429 https://orcid.org/0000-0002-2570-0770 https://orcid.org/0000-0003-3237-4034 https://orcid.org/0000-0002-0828-4357 https://orcid.org/0000-0002-2976-6195 |
| _version_ | 1810989018493485056 |
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| author | Tsai, Tsung-Han Lee, Hsiang-Chieh Liang, Kaicheng Potsaid, Benjamin M. Tao, Yuankai K. Jayaraman, Vijaysekhar Kraus, Martin F. Hornegger, Joachim Figueiredo, Marisa Huang, Qin Mashimo, Hiroshi Cable, Alex E. Fujimoto, James G. Ahsen, Osman Oguz Giacomelli, Michael Gene |
| author2 | Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science |
| author_facet | Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science Tsai, Tsung-Han Lee, Hsiang-Chieh Liang, Kaicheng Potsaid, Benjamin M. Tao, Yuankai K. Jayaraman, Vijaysekhar Kraus, Martin F. Hornegger, Joachim Figueiredo, Marisa Huang, Qin Mashimo, Hiroshi Cable, Alex E. Fujimoto, James G. Ahsen, Osman Oguz Giacomelli, Michael Gene |
| author_sort | Tsai, Tsung-Han |
| collection | MIT |
| description | We developed an ultrahigh speed endoscopic swept source optical coherence tomography (OCT) system for clinical gastroenterology using a vertical-cavity surface-emitting laser (VCSEL) and micromotor based imaging catheter, which provided an imaging speed of 600 kHz axial scan rate and 8 μm axial resolution in tissue. The micromotor catheter was 3.2 mm in diameter and could be introduced through the 3.7 mm accessory port of an endoscope. Imaging was performed at 400 frames per second with an 8 μm spot size using a pullback to generate volumetric data over 16 mm with a pixel spacing of 5 μm in the longitudinal direction. Three-dimensional OCT (3D-OCT) imaging was performed in patients with a cross section of pathologies undergoing standard upper and lower endoscopy at the Veterans Affairs Boston Healthcare System (VABHS). Patients with Barrett’s esophagus, dysplasia, and inflammatory bowel disease were imaged. The use of distally actuated imaging catheters allowed OCT imaging with more flexibility such as volumetric imaging in the terminal ileum and the assessment of the hiatal hernia using retroflex imaging. The high rotational stability of the micromotor enabled 3D volumetric imaging with micron scale volumetric accuracy for both en face and cross-sectional imaging. The ability to perform 3D OCT imaging in the GI tract with microscopic accuracy should enable a wide range of studies to investigate the ability of OCT to detect pathology as well as assess treatment response. |
| first_indexed | 2024-09-23T12:15:14Z |
| format | Article |
| id | mit-1721.1/100219 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T12:15:14Z |
| publishDate | 2015 |
| publisher | SPIE |
| record_format | dspace |
| spelling | mit-1721.1/1002192022-09-28T00:50:04Z Ultrahigh speed endoscopic swept source optical coherence tomography using a VCSEL light source and micromotor catheter Tsai, Tsung-Han Lee, Hsiang-Chieh Liang, Kaicheng Potsaid, Benjamin M. Tao, Yuankai K. Jayaraman, Vijaysekhar Kraus, Martin F. Hornegger, Joachim Figueiredo, Marisa Huang, Qin Mashimo, Hiroshi Cable, Alex E. Fujimoto, James G. Ahsen, Osman Oguz Giacomelli, Michael Gene Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science Massachusetts Institute of Technology. Research Laboratory of Electronics Tsai, Tsung-Han Ahsen, Osman Oguz Lee, Hsiang-Chieh Liang, Kaicheng Giacomelli, Michael Gene Potsaid, Benjamin M. Tao, Yuankai K. Kraus, Martin F. Fujimoto, James G. We developed an ultrahigh speed endoscopic swept source optical coherence tomography (OCT) system for clinical gastroenterology using a vertical-cavity surface-emitting laser (VCSEL) and micromotor based imaging catheter, which provided an imaging speed of 600 kHz axial scan rate and 8 μm axial resolution in tissue. The micromotor catheter was 3.2 mm in diameter and could be introduced through the 3.7 mm accessory port of an endoscope. Imaging was performed at 400 frames per second with an 8 μm spot size using a pullback to generate volumetric data over 16 mm with a pixel spacing of 5 μm in the longitudinal direction. Three-dimensional OCT (3D-OCT) imaging was performed in patients with a cross section of pathologies undergoing standard upper and lower endoscopy at the Veterans Affairs Boston Healthcare System (VABHS). Patients with Barrett’s esophagus, dysplasia, and inflammatory bowel disease were imaged. The use of distally actuated imaging catheters allowed OCT imaging with more flexibility such as volumetric imaging in the terminal ileum and the assessment of the hiatal hernia using retroflex imaging. The high rotational stability of the micromotor enabled 3D volumetric imaging with micron scale volumetric accuracy for both en face and cross-sectional imaging. The ability to perform 3D OCT imaging in the GI tract with microscopic accuracy should enable a wide range of studies to investigate the ability of OCT to detect pathology as well as assess treatment response. National Institutes of Health (U.S.) (R44EY022864-01) National Institutes of Health (U.S.) (R01-CA75289-17) National Institutes of Health (U.S.) (R44-CA101067-06) National Institutes of Health (U.S.) ( R01-EY011289-27) National Institutes of Health (U.S.) (R01-HL095717-04) National Institutes of Health (U.S.) (R01-NS057476-05) United States. Air Force Office of Scientific Research (FA9550-10-1-0063) United States. Air Force Office of Scientific Research. Medical Free Electron Laser Program (FA9550-10-1-0551) German Research Foundation (DFG-GSC80-SAOT) German Research Foundation (DFG-HO-1791/11-1) Center for Integration of Medicine and Innovative Technology 2015-12-13T20:08:20Z 2015-12-13T20:08:20Z 2014-03 Article http://purl.org/eprint/type/ConferencePaper 0277-786X 1605-7422 http://hdl.handle.net/1721.1/100219 Tsai, Tsung-Han, Osman O. Ahsen, Hsiang-Chieh Lee, Kaicheng Liang, Michael G. Giacomelli, Benjamin M. Potsaid, Yuankai K. Tao, et al. “Ultrahigh Speed Endoscopic Swept Source Optical Coherence Tomography Using a VCSEL Light Source and Micromotor Catheter.” Edited by Melissa J. Suter, Stephen Lam, Matthew Brenner, Guillermo J. Tearney, and Thomas D. Wang. Endoscopic Microscopy IX; and Optical Techniques in Pulmonary Medicine (March 4, 2014). © 2014 Society of Photo-Optical Instrumentation Engineers (SPIE) https://orcid.org/0000-0003-4811-3429 https://orcid.org/0000-0002-2570-0770 https://orcid.org/0000-0003-3237-4034 https://orcid.org/0000-0002-0828-4357 https://orcid.org/0000-0002-2976-6195 en_US http://dx.doi.org/10.1117/12.2040417 Proceedings of SPIE--the International Society for Optical Engineering Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf SPIE SPIE |
| spellingShingle | Tsai, Tsung-Han Lee, Hsiang-Chieh Liang, Kaicheng Potsaid, Benjamin M. Tao, Yuankai K. Jayaraman, Vijaysekhar Kraus, Martin F. Hornegger, Joachim Figueiredo, Marisa Huang, Qin Mashimo, Hiroshi Cable, Alex E. Fujimoto, James G. Ahsen, Osman Oguz Giacomelli, Michael Gene Ultrahigh speed endoscopic swept source optical coherence tomography using a VCSEL light source and micromotor catheter |
| title | Ultrahigh speed endoscopic swept source optical coherence tomography using a VCSEL light source and micromotor catheter |
| title_full | Ultrahigh speed endoscopic swept source optical coherence tomography using a VCSEL light source and micromotor catheter |
| title_fullStr | Ultrahigh speed endoscopic swept source optical coherence tomography using a VCSEL light source and micromotor catheter |
| title_full_unstemmed | Ultrahigh speed endoscopic swept source optical coherence tomography using a VCSEL light source and micromotor catheter |
| title_short | Ultrahigh speed endoscopic swept source optical coherence tomography using a VCSEL light source and micromotor catheter |
| title_sort | ultrahigh speed endoscopic swept source optical coherence tomography using a vcsel light source and micromotor catheter |
| url | http://hdl.handle.net/1721.1/100219 https://orcid.org/0000-0003-4811-3429 https://orcid.org/0000-0002-2570-0770 https://orcid.org/0000-0003-3237-4034 https://orcid.org/0000-0002-0828-4357 https://orcid.org/0000-0002-2976-6195 |
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