Gaussian Process Interpolation for Uncertainty Estimation in Image Registration

Intensity-based image registration requires resampling images on a common grid to evaluate the similarity function. The uncertainty of interpolation varies across the image, depending on the location of resampled points relative to the base grid. We propose to perform Bayesian inference with Gaussia...

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Main Authors: Wachinger, Christian, Golland, Polina, Reuter, Martin, Wells, William M.
Other Authors: Massachusetts Institute of Technology. Computer Science and Artificial Intelligence Laboratory
Format: Article
Language:en_US
Published: Springer-Verlag 2015
Online Access:http://hdl.handle.net/1721.1/100261
https://orcid.org/0000-0002-3652-1874
https://orcid.org/0000-0003-2516-731X
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author Wachinger, Christian
Golland, Polina
Reuter, Martin
Wells, William M.
author2 Massachusetts Institute of Technology. Computer Science and Artificial Intelligence Laboratory
author_facet Massachusetts Institute of Technology. Computer Science and Artificial Intelligence Laboratory
Wachinger, Christian
Golland, Polina
Reuter, Martin
Wells, William M.
author_sort Wachinger, Christian
collection MIT
description Intensity-based image registration requires resampling images on a common grid to evaluate the similarity function. The uncertainty of interpolation varies across the image, depending on the location of resampled points relative to the base grid. We propose to perform Bayesian inference with Gaussian processes, where the covariance matrix of the Gaussian process posterior distribution estimates the uncertainty in interpolation. The Gaussian process replaces a single image with a distribution over images that we integrate into a generative model for registration. Marginalization over resampled images leads to a new similarity measure that includes the uncertainty of the interpolation. We demonstrate that our approach increases the registration accuracy and propose an efficient approximation scheme that enables seamless integration with existing registration methods.
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spelling mit-1721.1/1002612022-09-30T10:57:00Z Gaussian Process Interpolation for Uncertainty Estimation in Image Registration Wachinger, Christian Golland, Polina Reuter, Martin Wells, William M. Massachusetts Institute of Technology. Computer Science and Artificial Intelligence Laboratory Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science Wachinger, Christian Golland, Polina Reuter, Martin Wells, William M. Intensity-based image registration requires resampling images on a common grid to evaluate the similarity function. The uncertainty of interpolation varies across the image, depending on the location of resampled points relative to the base grid. We propose to perform Bayesian inference with Gaussian processes, where the covariance matrix of the Gaussian process posterior distribution estimates the uncertainty in interpolation. The Gaussian process replaces a single image with a distribution over images that we integrate into a generative model for registration. Marginalization over resampled images leads to a new similarity measure that includes the uncertainty of the interpolation. We demonstrate that our approach increases the registration accuracy and propose an efficient approximation scheme that enables seamless integration with existing registration methods. Alexander von Humboldt-Stiftung National Alliance for Medical Image Computing (U.S.) (U54-EB005149) Neuroimaging Analysis Center (U.S.) (P41-EB015902) National Center for Image-Guided Therapy (U.S.) (P41-EB015898) 2015-12-15T15:23:57Z 2015-12-15T15:23:57Z 2014 Article http://purl.org/eprint/type/ConferencePaper 978-3-319-10403-4 978-3-319-10404-1 0302-9743 1611-3349 http://hdl.handle.net/1721.1/100261 Wachinger, Christian, Polina Golland, Martin Reuter, and William Wells. “Gaussian Process Interpolation for Uncertainty Estimation in Image Registration.” Lecture Notes in Computer Science (2014): 267–274. https://orcid.org/0000-0002-3652-1874 https://orcid.org/0000-0003-2516-731X en_US http://dx.doi.org/10.1007/978-3-319-10404-1_34 Medical Image Computing and Computer-Assisted Intervention – MICCAI 2014 Creative Commons Attribution-Noncommercial-Share Alike http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf Springer-Verlag PMC
spellingShingle Wachinger, Christian
Golland, Polina
Reuter, Martin
Wells, William M.
Gaussian Process Interpolation for Uncertainty Estimation in Image Registration
title Gaussian Process Interpolation for Uncertainty Estimation in Image Registration
title_full Gaussian Process Interpolation for Uncertainty Estimation in Image Registration
title_fullStr Gaussian Process Interpolation for Uncertainty Estimation in Image Registration
title_full_unstemmed Gaussian Process Interpolation for Uncertainty Estimation in Image Registration
title_short Gaussian Process Interpolation for Uncertainty Estimation in Image Registration
title_sort gaussian process interpolation for uncertainty estimation in image registration
url http://hdl.handle.net/1721.1/100261
https://orcid.org/0000-0002-3652-1874
https://orcid.org/0000-0003-2516-731X
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