Gene expression analysis in Fmr1KO mice identifies an immunological signature in brain tissue and mGluR5-related signaling in primary neuronal cultures

Gene expression analysis in Fmr1KO mice identifies an immunological signature in brain tissue and mGluR5-related signaling in primary neuronal cultures

Background Fragile X syndrome (FXS) is a neurodevelopmental disorder whose biochemical manifestations involve dysregulation of mGluR5-dependent pathways, which are widely modeled using cultured neurons. In vitro phenotypes in cultured neurons using standard morphological, functional, and chemical a...

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Bibliographic Details
Main Authors: Prilutsky, Daria, Kho, Alvin T., Palmer, Nathan Patrick, Bhakar, Asha L., Smedemark-Margulies, Niklas, Kong, Sek Won, Margulies, David M., Bear, Mark F., Kohane, Isaac S.
Other Authors: Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences
Format: Article
Language:English
Published: BioMed Central 2015
Online Access:http://hdl.handle.net/1721.1/100495

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