Foldable and Cytocompatible Sol-gel TiO[subscript 2] Photonics
Integrated photonics provides a miniaturized and potentially implantable platform to manipulate and enhance the interactions between light and biological molecules or tissues in in-vitro and in-vivo settings, and is thus being increasingly adopted in a wide cross-section of biomedical applications r...
| Main Authors: | , , , , , , , , , , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | en_US |
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Nature Publishing Group
2015
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| Online Access: | http://hdl.handle.net/1721.1/100534 https://orcid.org/0000-0002-7233-3918 |
| _version_ | 1811076126380916736 |
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| author | Li, Lan Zhang, Ping Wang, Wei-Ming Lin, Hongtao Zerdoum, Aidan B. Geiger, Sarah J. Liu, Yangchen Xiao, Nicholas Zou, Yi Ogbuu, Okechukwu Du, Qingyang Jia, Xinqiao Li, Jingjing Hu, Juejun |
| author2 | Massachusetts Institute of Technology. Department of Materials Science and Engineering |
| author_facet | Massachusetts Institute of Technology. Department of Materials Science and Engineering Li, Lan Zhang, Ping Wang, Wei-Ming Lin, Hongtao Zerdoum, Aidan B. Geiger, Sarah J. Liu, Yangchen Xiao, Nicholas Zou, Yi Ogbuu, Okechukwu Du, Qingyang Jia, Xinqiao Li, Jingjing Hu, Juejun |
| author_sort | Li, Lan |
| collection | MIT |
| description | Integrated photonics provides a miniaturized and potentially implantable platform to manipulate and enhance the interactions between light and biological molecules or tissues in in-vitro and in-vivo settings, and is thus being increasingly adopted in a wide cross-section of biomedical applications ranging from disease diagnosis to optogenetic neuromodulation. However, the mechanical rigidity of substrates traditionally used for photonic integration is fundamentally incompatible with soft biological tissues. Cytotoxicity of materials and chemicals used in photonic device processing imposes another constraint towards these biophotonic applications. Here we present thin film TiO[subscript 2] as a viable material for biocompatible and flexible integrated photonics. Amorphous TiO[subscript 2] films were deposited using a low temperature (<250 °C) sol-gel process fully compatible with monolithic integration on plastic substrates. High-index-contrast flexible optical waveguides and resonators were fabricated using the sol-gel TiO[subscript 2] material, and resonator quality factors up to 20,000 were measured. Following a multi-neutral-axis mechanical design, these devices exhibit remarkable mechanical flexibility, and can sustain repeated folding without compromising their optical performance. Finally, we validated the low cytotoxicity of the sol-gel TiO[subscript 2] devices through in-vitro cell culture tests. These results demonstrate the potential of sol-gel TiO[subscript 2] as a promising material platform for novel biophotonic devices. |
| first_indexed | 2024-09-23T10:16:37Z |
| format | Article |
| id | mit-1721.1/100534 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T10:16:37Z |
| publishDate | 2015 |
| publisher | Nature Publishing Group |
| record_format | dspace |
| spelling | mit-1721.1/1005342022-09-30T20:05:19Z Foldable and Cytocompatible Sol-gel TiO[subscript 2] Photonics Li, Lan Zhang, Ping Wang, Wei-Ming Lin, Hongtao Zerdoum, Aidan B. Geiger, Sarah J. Liu, Yangchen Xiao, Nicholas Zou, Yi Ogbuu, Okechukwu Du, Qingyang Jia, Xinqiao Li, Jingjing Hu, Juejun Massachusetts Institute of Technology. Department of Materials Science and Engineering Hu, Juejun Integrated photonics provides a miniaturized and potentially implantable platform to manipulate and enhance the interactions between light and biological molecules or tissues in in-vitro and in-vivo settings, and is thus being increasingly adopted in a wide cross-section of biomedical applications ranging from disease diagnosis to optogenetic neuromodulation. However, the mechanical rigidity of substrates traditionally used for photonic integration is fundamentally incompatible with soft biological tissues. Cytotoxicity of materials and chemicals used in photonic device processing imposes another constraint towards these biophotonic applications. Here we present thin film TiO[subscript 2] as a viable material for biocompatible and flexible integrated photonics. Amorphous TiO[subscript 2] films were deposited using a low temperature (<250 °C) sol-gel process fully compatible with monolithic integration on plastic substrates. High-index-contrast flexible optical waveguides and resonators were fabricated using the sol-gel TiO[subscript 2] material, and resonator quality factors up to 20,000 were measured. Following a multi-neutral-axis mechanical design, these devices exhibit remarkable mechanical flexibility, and can sustain repeated folding without compromising their optical performance. Finally, we validated the low cytotoxicity of the sol-gel TiO[subscript 2] devices through in-vitro cell culture tests. These results demonstrate the potential of sol-gel TiO[subscript 2] as a promising material platform for novel biophotonic devices. National Science Foundation (U.S.) (Award 1453218) National Institutes of Health (U.S.) (Award R01DC011377) 2015-12-28T15:25:25Z 2015-12-28T15:25:25Z 2015-09 2015-05 Article http://purl.org/eprint/type/JournalArticle 2045-2322 http://hdl.handle.net/1721.1/100534 Li, Lan, Ping Zhang, Wei-Ming Wang, Hongtao Lin, Aidan B. Zerdoum, Sarah J. Geiger, Yangchen Liu, et al. “Foldable and Cytocompatible Sol-Gel TiO2 Photonics.” Scientific Reports 5 (September 7, 2015): 13832. https://orcid.org/0000-0002-7233-3918 en_US http://dx.doi.org/10.1038/srep13832 Scientific Reports Creative Commons Attribution http://creativecommons.org/licenses/by/4.0/ application/pdf Nature Publishing Group Nature Publishing Group |
| spellingShingle | Li, Lan Zhang, Ping Wang, Wei-Ming Lin, Hongtao Zerdoum, Aidan B. Geiger, Sarah J. Liu, Yangchen Xiao, Nicholas Zou, Yi Ogbuu, Okechukwu Du, Qingyang Jia, Xinqiao Li, Jingjing Hu, Juejun Foldable and Cytocompatible Sol-gel TiO[subscript 2] Photonics |
| title | Foldable and Cytocompatible Sol-gel TiO[subscript 2] Photonics |
| title_full | Foldable and Cytocompatible Sol-gel TiO[subscript 2] Photonics |
| title_fullStr | Foldable and Cytocompatible Sol-gel TiO[subscript 2] Photonics |
| title_full_unstemmed | Foldable and Cytocompatible Sol-gel TiO[subscript 2] Photonics |
| title_short | Foldable and Cytocompatible Sol-gel TiO[subscript 2] Photonics |
| title_sort | foldable and cytocompatible sol gel tio subscript 2 photonics |
| url | http://hdl.handle.net/1721.1/100534 https://orcid.org/0000-0002-7233-3918 |
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