Improved accuracy in susceptibility-based OEF measurements by mitigation of partial-volume effects via combined magnitude and phase reconstruction
Thesis: M. Eng., Massachusetts Institute of Technology, Department of Electrical Engineering and Computer Science, 2015.
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| Format: | Thesis |
| Language: | eng |
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Massachusetts Institute of Technology
2016
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| Online Access: | http://hdl.handle.net/1721.1/100637 |
| _version_ | 1826214302253580288 |
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| author | McDaniel, Patrick Christopher |
| author2 | Elfar Adalsteinsson. |
| author_facet | Elfar Adalsteinsson. McDaniel, Patrick Christopher |
| author_sort | McDaniel, Patrick Christopher |
| collection | MIT |
| description | Thesis: M. Eng., Massachusetts Institute of Technology, Department of Electrical Engineering and Computer Science, 2015. |
| first_indexed | 2024-09-23T16:03:22Z |
| format | Thesis |
| id | mit-1721.1/100637 |
| institution | Massachusetts Institute of Technology |
| language | eng |
| last_indexed | 2024-09-23T16:03:22Z |
| publishDate | 2016 |
| publisher | Massachusetts Institute of Technology |
| record_format | dspace |
| spelling | mit-1721.1/1006372020-12-07T13:31:49Z Improved accuracy in susceptibility-based OEF measurements by mitigation of partial-volume effects via combined magnitude and phase reconstruction Improved accuracy in susceptibility-based MRI oxygenation measurements by mitigation of partial-volume effects via combined magnitude and phase reconstruction McDaniel, Patrick Christopher Elfar Adalsteinsson. Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science. Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science Electrical Engineering and Computer Science. Thesis: M. Eng., Massachusetts Institute of Technology, Department of Electrical Engineering and Computer Science, 2015. This electronic version was submitted by the student author. The certified thesis is available in the Institute Archives and Special Collections. Title as it appears in MIT Commencement Exercises program, June 5, 2015: Improved accuracy in susceptibility-based MRI oxygenation measurements by mitigation of partial-volume effects via combined magnitude and phase reconstruction. Cataloged from student-submitted PDF version of thesis. Includes bibliographical references. Regional quantitative Oxygen Extraction Fraction (OEF) values can only be reliable obtained from blood vessels larger than the acquisition voxel size. Blood vessels beyond this limit produce unreliable measurements due to partial-volume effects. We demonstrate a method for obtaining more reliable OEF measurements beyond this limit by performing a joint reconstruction using both the magnitude and phase of the complex-valued MRI signal. This method is validated both in numerical simulations and on in vivo data. The ability to perform high-quality fetal brain imaging is hampered by motion of the fetus, which can severely degrade image quality. Previously, low-resolution volumetric navigator (vNav) acquisitions have been shown to accurately track motion in human adults and prospectively correct for it. Here, a technique for using vNavs to measure fetal head motion in utero is developed and validated on in vivo data. Parallel Transmission (pTx) improves image quality and patient safety in high-field MRI. Unlike in single-channel MR excitation, an array of multiple excitation coils is used in pTx. However, coupling between these independent coils significantly degrades the power efficiency of the pTx array. Previously, it a decoupling matrix was proposed to solve this inefficiency. In this work, a physical realization of a 4-channel decoupling matrix was constructed and tested. by Patrick C. McDaniel. M. Eng. 2016-01-04T20:00:59Z 2016-01-04T20:00:59Z 2015 2015 Thesis http://hdl.handle.net/1721.1/100637 933233070 eng M.I.T. theses are protected by copyright. They may be viewed from this source for any purpose, but reproduction or distribution in any format is prohibited without written permission. See provided URL for inquiries about permission. http://dspace.mit.edu/handle/1721.1/7582 102 pages application/pdf Massachusetts Institute of Technology |
| spellingShingle | Electrical Engineering and Computer Science. McDaniel, Patrick Christopher Improved accuracy in susceptibility-based OEF measurements by mitigation of partial-volume effects via combined magnitude and phase reconstruction |
| title | Improved accuracy in susceptibility-based OEF measurements by mitigation of partial-volume effects via combined magnitude and phase reconstruction |
| title_full | Improved accuracy in susceptibility-based OEF measurements by mitigation of partial-volume effects via combined magnitude and phase reconstruction |
| title_fullStr | Improved accuracy in susceptibility-based OEF measurements by mitigation of partial-volume effects via combined magnitude and phase reconstruction |
| title_full_unstemmed | Improved accuracy in susceptibility-based OEF measurements by mitigation of partial-volume effects via combined magnitude and phase reconstruction |
| title_short | Improved accuracy in susceptibility-based OEF measurements by mitigation of partial-volume effects via combined magnitude and phase reconstruction |
| title_sort | improved accuracy in susceptibility based oef measurements by mitigation of partial volume effects via combined magnitude and phase reconstruction |
| topic | Electrical Engineering and Computer Science. |
| url | http://hdl.handle.net/1721.1/100637 |
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