Core and region-enriched networks of behaviorally regulated genes and the singing genome
Songbirds represent an important model organism for elucidating molecular mechanisms that link genes with complex behaviors, in part because they have discrete vocal learning circuits that have parallels with those that mediate human speech. We found that ~10% of the genes in the avian genome were r...
| Main Authors: | , , , , , , , , , , , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | en_US |
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American Association for the Advancement of Science (AAAS)
2016
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| Online Access: | http://hdl.handle.net/1721.1/100802 https://orcid.org/0000-0002-3447-9801 |
| _version_ | 1826193287432634368 |
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| author | Whitney, Osceola Pfenning, Andreas R. Howard, Jason T. Blatti, Charles A. Liu, Fang Ward, James M. Wang, Rui Audet, Jean-Nicolas Kellis, Manolis Mukherjee, Sayan Sinha, Saurabh Hartemink, Alexander J. West, Anne E. Jarvis, Erich D. |
| author2 | Massachusetts Institute of Technology. Computer Science and Artificial Intelligence Laboratory |
| author_facet | Massachusetts Institute of Technology. Computer Science and Artificial Intelligence Laboratory Whitney, Osceola Pfenning, Andreas R. Howard, Jason T. Blatti, Charles A. Liu, Fang Ward, James M. Wang, Rui Audet, Jean-Nicolas Kellis, Manolis Mukherjee, Sayan Sinha, Saurabh Hartemink, Alexander J. West, Anne E. Jarvis, Erich D. |
| author_sort | Whitney, Osceola |
| collection | MIT |
| description | Songbirds represent an important model organism for elucidating molecular mechanisms that link genes with complex behaviors, in part because they have discrete vocal learning circuits that have parallels with those that mediate human speech. We found that ~10% of the genes in the avian genome were regulated by singing, and we found a striking regional diversity of both basal and singing-induced programs in the four key song nuclei of the zebra finch, a vocal learning songbird. The region-enriched patterns were a result of distinct combinations of region-enriched transcription factors (TFs), their binding motifs, and presinging acetylation of histone 3 at lysine 27 (H3K27ac) enhancer activity in the regulatory regions of the associated genes. RNA interference manipulations validated the role of the calcium-response transcription factor (CaRF) in regulating genes preferentially expressed in specific song nuclei in response to singing. Thus, differential combinatorial binding of a small group of activity-regulated TFs and predefined epigenetic enhancer activity influences the anatomical diversity of behaviorally regulated gene networks. |
| first_indexed | 2024-09-23T09:36:37Z |
| format | Article |
| id | mit-1721.1/100802 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T09:36:37Z |
| publishDate | 2016 |
| publisher | American Association for the Advancement of Science (AAAS) |
| record_format | dspace |
| spelling | mit-1721.1/1008022022-09-26T12:39:44Z Core and region-enriched networks of behaviorally regulated genes and the singing genome Whitney, Osceola Pfenning, Andreas R. Howard, Jason T. Blatti, Charles A. Liu, Fang Ward, James M. Wang, Rui Audet, Jean-Nicolas Kellis, Manolis Mukherjee, Sayan Sinha, Saurabh Hartemink, Alexander J. West, Anne E. Jarvis, Erich D. Massachusetts Institute of Technology. Computer Science and Artificial Intelligence Laboratory Massachusetts Institute of Technology. Department of Electrical Engineering and Computer Science Pfenning, Andreas R. Kellis, Manolis Songbirds represent an important model organism for elucidating molecular mechanisms that link genes with complex behaviors, in part because they have discrete vocal learning circuits that have parallels with those that mediate human speech. We found that ~10% of the genes in the avian genome were regulated by singing, and we found a striking regional diversity of both basal and singing-induced programs in the four key song nuclei of the zebra finch, a vocal learning songbird. The region-enriched patterns were a result of distinct combinations of region-enriched transcription factors (TFs), their binding motifs, and presinging acetylation of histone 3 at lysine 27 (H3K27ac) enhancer activity in the regulatory regions of the associated genes. RNA interference manipulations validated the role of the calcium-response transcription factor (CaRF) in regulating genes preferentially expressed in specific song nuclei in response to singing. Thus, differential combinatorial binding of a small group of activity-regulated TFs and predefined epigenetic enhancer activity influences the anatomical diversity of behaviorally regulated gene networks. 2016-01-12T15:05:32Z 2016-01-12T15:05:32Z 2014-12 2014-06 Article http://purl.org/eprint/type/JournalArticle 0036-8075 1095-9203 http://hdl.handle.net/1721.1/100802 Whitney, O., A. R. Pfenning, J. T. Howard, C. A. Blatti, F. Liu, J. M. Ward, R. Wang, et al. “Core and Region-Enriched Networks of Behaviorally Regulated Genes and the Singing Genome.” Science 346, no. 6215 (December 11, 2014): 1256780–1256780. https://orcid.org/0000-0002-3447-9801 en_US http://dx.doi.org/10.1126/science.1256780 Science Creative Commons Attribution-Noncommercial-Share Alike http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf American Association for the Advancement of Science (AAAS) PMC |
| spellingShingle | Whitney, Osceola Pfenning, Andreas R. Howard, Jason T. Blatti, Charles A. Liu, Fang Ward, James M. Wang, Rui Audet, Jean-Nicolas Kellis, Manolis Mukherjee, Sayan Sinha, Saurabh Hartemink, Alexander J. West, Anne E. Jarvis, Erich D. Core and region-enriched networks of behaviorally regulated genes and the singing genome |
| title | Core and region-enriched networks of behaviorally regulated genes and the singing genome |
| title_full | Core and region-enriched networks of behaviorally regulated genes and the singing genome |
| title_fullStr | Core and region-enriched networks of behaviorally regulated genes and the singing genome |
| title_full_unstemmed | Core and region-enriched networks of behaviorally regulated genes and the singing genome |
| title_short | Core and region-enriched networks of behaviorally regulated genes and the singing genome |
| title_sort | core and region enriched networks of behaviorally regulated genes and the singing genome |
| url | http://hdl.handle.net/1721.1/100802 https://orcid.org/0000-0002-3447-9801 |
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