Coil-globule transition of a single semiflexible chain in slitlike confinement
Single polymer chains undergo a phase transition from coiled conformations to globular conformations as the effective attraction between monomers becomes strong enough. In this work, we investigated the coil-globule transition of a semiflexible chain confined between two parallel plates, i.e. a slit...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | en_US |
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Nature Publishing Group
2016
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| Online Access: | http://hdl.handle.net/1721.1/100922 https://orcid.org/0000-0003-1687-4522 |
| _version_ | 1826199402747789312 |
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| author | Dai, Liang Renner, C. Benjamin Yan, Jie Doyle, Patrick S. |
| author2 | Massachusetts Institute of Technology. Department of Chemical Engineering |
| author_facet | Massachusetts Institute of Technology. Department of Chemical Engineering Dai, Liang Renner, C. Benjamin Yan, Jie Doyle, Patrick S. |
| author_sort | Dai, Liang |
| collection | MIT |
| description | Single polymer chains undergo a phase transition from coiled conformations to globular conformations as the effective attraction between monomers becomes strong enough. In this work, we investigated the coil-globule transition of a semiflexible chain confined between two parallel plates, i.e. a slit, using the lattice model and Pruned-enriched Rosenbluth method (PERM) algorithm. We find that as the slit height decreases, the critical attraction for the coil-globule transition changes non-monotonically due to the competition of the confinement free energies of the coiled and globular states. In wide (narrow) slits, the coiled state experiences more (less) confinement free energy, and hence the transition becomes easier (more difficult). In addition, we find that the transition becomes less sharp with the decreasing slit height. Here, the sharpness refers to the sensitivity of thermodynamic quantities when varying the attraction around the critical value. The relevant experiments can be performed for DNA condensation in microfluidic devices. |
| first_indexed | 2024-09-23T11:19:20Z |
| format | Article |
| id | mit-1721.1/100922 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T11:19:20Z |
| publishDate | 2016 |
| publisher | Nature Publishing Group |
| record_format | dspace |
| spelling | mit-1721.1/1009222022-10-01T02:49:25Z Coil-globule transition of a single semiflexible chain in slitlike confinement Dai, Liang Renner, C. Benjamin Yan, Jie Doyle, Patrick S. Massachusetts Institute of Technology. Department of Chemical Engineering Renner, C. Benjamin Doyle, Patrick S. Single polymer chains undergo a phase transition from coiled conformations to globular conformations as the effective attraction between monomers becomes strong enough. In this work, we investigated the coil-globule transition of a semiflexible chain confined between two parallel plates, i.e. a slit, using the lattice model and Pruned-enriched Rosenbluth method (PERM) algorithm. We find that as the slit height decreases, the critical attraction for the coil-globule transition changes non-monotonically due to the competition of the confinement free energies of the coiled and globular states. In wide (narrow) slits, the coiled state experiences more (less) confinement free energy, and hence the transition becomes easier (more difficult). In addition, we find that the transition becomes less sharp with the decreasing slit height. Here, the sharpness refers to the sensitivity of thermodynamic quantities when varying the attraction around the critical value. The relevant experiments can be performed for DNA condensation in microfluidic devices. Singapore-MIT Alliance for Research and Technology Center National Science Foundation (U.S.) (CBET-1335938) 2016-01-19T17:32:40Z 2016-01-19T17:32:40Z 2015-12 2015-08 Article http://purl.org/eprint/type/JournalArticle 2045-2322 http://hdl.handle.net/1721.1/100922 Dai, Liang, C. Benjamin Renner, Jie Yan, and Patrick S. Doyle. “Coil-Globule Transition of a Single Semiflexible Chain in Slitlike Confinement.” Scientific Reports 5 (December 18, 2015): 18438. https://orcid.org/0000-0003-1687-4522 en_US http://dx.doi.org/10.1038/srep18438 Scientific Reports Creative Commons Attribution http://creativecommons.org/licenses/by/4.0/ application/pdf Nature Publishing Group Nature Publishing Group |
| spellingShingle | Dai, Liang Renner, C. Benjamin Yan, Jie Doyle, Patrick S. Coil-globule transition of a single semiflexible chain in slitlike confinement |
| title | Coil-globule transition of a single semiflexible chain in slitlike confinement |
| title_full | Coil-globule transition of a single semiflexible chain in slitlike confinement |
| title_fullStr | Coil-globule transition of a single semiflexible chain in slitlike confinement |
| title_full_unstemmed | Coil-globule transition of a single semiflexible chain in slitlike confinement |
| title_short | Coil-globule transition of a single semiflexible chain in slitlike confinement |
| title_sort | coil globule transition of a single semiflexible chain in slitlike confinement |
| url | http://hdl.handle.net/1721.1/100922 https://orcid.org/0000-0003-1687-4522 |
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