Distinct speed dependence of entorhinal island and ocean cells, including respective grid cells
Entorhinal–hippocampal circuits in the mammalian brain are crucial for an animal’s spatial and episodic experience, but the neural basis for different spatial computations remain unknown. Medial entorhinal cortex layer II contains pyramidal island and stellate ocean cells. Here, we performed cell ty...
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | en_US |
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National Academy of Sciences (U.S.)
2016
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| Online Access: | http://hdl.handle.net/1721.1/101119 https://orcid.org/0000-0002-2419-794X https://orcid.org/0000-0003-2839-8228 |
| _version_ | 1826202987065769984 |
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| author | Sun, Chen Kitamura, Takashi Yamamoto, Jun Martin, Jared Kitch, Lacey J. Schnitzer, Mark J. Tonegawa, Susumu Pignatelli di Spinazzola, Michele |
| author2 | Massachusetts Institute of Technology. Department of Biology |
| author_facet | Massachusetts Institute of Technology. Department of Biology Sun, Chen Kitamura, Takashi Yamamoto, Jun Martin, Jared Kitch, Lacey J. Schnitzer, Mark J. Tonegawa, Susumu Pignatelli di Spinazzola, Michele |
| author_sort | Sun, Chen |
| collection | MIT |
| description | Entorhinal–hippocampal circuits in the mammalian brain are crucial for an animal’s spatial and episodic experience, but the neural basis for different spatial computations remain unknown. Medial entorhinal cortex layer II contains pyramidal island and stellate ocean cells. Here, we performed cell type-specific Ca[superscript 2+] imaging in freely exploring mice using cellular markers and a miniature head-mounted fluorescence microscope. We found that both oceans and islands contain grid cells in similar proportions, but island cell activity, including activity in a proportion of grid cells, is significantly more speed modulated than ocean cell activity. We speculate that this differential property reflects island cells’ and ocean cells’ contribution to different downstream functions: island cells may contribute more to spatial path integration, whereas ocean cells may facilitate contextual representation in downstream circuits. |
| first_indexed | 2024-09-23T12:28:43Z |
| format | Article |
| id | mit-1721.1/101119 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T12:28:43Z |
| publishDate | 2016 |
| publisher | National Academy of Sciences (U.S.) |
| record_format | dspace |
| spelling | mit-1721.1/1011192022-10-01T09:19:27Z Distinct speed dependence of entorhinal island and ocean cells, including respective grid cells Sun, Chen Kitamura, Takashi Yamamoto, Jun Martin, Jared Kitch, Lacey J. Schnitzer, Mark J. Tonegawa, Susumu Pignatelli di Spinazzola, Michele Massachusetts Institute of Technology. Department of Biology Massachusetts Institute of Technology. Department of Brain and Cognitive Sciences Picower Institute for Learning and Memory RIKEN-MIT Center for Neural Circuit Genetics Sun, Chen Kitamura, Takashi Yamamoto, Jun Martin, Jared Pignatelli di Spinazzola, Michele Tonegawa, Susumu Entorhinal–hippocampal circuits in the mammalian brain are crucial for an animal’s spatial and episodic experience, but the neural basis for different spatial computations remain unknown. Medial entorhinal cortex layer II contains pyramidal island and stellate ocean cells. Here, we performed cell type-specific Ca[superscript 2+] imaging in freely exploring mice using cellular markers and a miniature head-mounted fluorescence microscope. We found that both oceans and islands contain grid cells in similar proportions, but island cell activity, including activity in a proportion of grid cells, is significantly more speed modulated than ocean cell activity. We speculate that this differential property reflects island cells’ and ocean cells’ contribution to different downstream functions: island cells may contribute more to spatial path integration, whereas ocean cells may facilitate contextual representation in downstream circuits. RIKEN Brain Science Institute Picower Institute for Learning and Memory (Innovation Fund) JPB Foundation 2016-02-05T15:06:14Z 2016-02-05T15:06:14Z 2015-07 2015-06 Article http://purl.org/eprint/type/JournalArticle 0027-8424 1091-6490 http://hdl.handle.net/1721.1/101119 Sun, Chen, Takashi Kitamura, Jun Yamamoto, Jared Martin, Michele Pignatelli, Lacey J. Kitch, Mark J. Schnitzer, and Susumu Tonegawa. “Distinct Speed Dependence of Entorhinal Island and Ocean Cells, Including Respective Grid Cells.” Proc Natl Acad Sci USA 112, no. 30 (July 13, 2015): 9466–9471. https://orcid.org/0000-0002-2419-794X https://orcid.org/0000-0003-2839-8228 en_US http://dx.doi.org/10.1073/pnas.1511668112 Proceedings of the National Academy of Sciences Article is made available in accordance with the publisher's policy and may be subject to US copyright law. Please refer to the publisher's site for terms of use. application/pdf National Academy of Sciences (U.S.) National Academy of Sciences (U.S.) |
| spellingShingle | Sun, Chen Kitamura, Takashi Yamamoto, Jun Martin, Jared Kitch, Lacey J. Schnitzer, Mark J. Tonegawa, Susumu Pignatelli di Spinazzola, Michele Distinct speed dependence of entorhinal island and ocean cells, including respective grid cells |
| title | Distinct speed dependence of entorhinal island and ocean cells, including respective grid cells |
| title_full | Distinct speed dependence of entorhinal island and ocean cells, including respective grid cells |
| title_fullStr | Distinct speed dependence of entorhinal island and ocean cells, including respective grid cells |
| title_full_unstemmed | Distinct speed dependence of entorhinal island and ocean cells, including respective grid cells |
| title_short | Distinct speed dependence of entorhinal island and ocean cells, including respective grid cells |
| title_sort | distinct speed dependence of entorhinal island and ocean cells including respective grid cells |
| url | http://hdl.handle.net/1721.1/101119 https://orcid.org/0000-0002-2419-794X https://orcid.org/0000-0003-2839-8228 |
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