Lipid-Like Nanomaterials for Simultaneous Gene Expression and Silencing In Vivo

Lipid-Like Nanomaterials for Simultaneous Gene Expression and Silencing In Vivo

New lipid-like nanomaterials are developed to simultaneously regulate expression of multiple genes. Self-assembled nanoparticles are capable of efficiently encapsulating pDNA and siRNA. These nanoparticles are shown to induce simultaneous gene expression and silencing both in vitro and in vivo.

Bibliographic Details
Main Authors: Dong, Yizhou, Eltoukhy, Ahmed A., Alabi, Christopher A., Veiseh, Omid, Sirirungruang, Sasilada, Yin, Hao, Tang, Benjamin C., Chen, Delai, Gu, Zhen, Xue, Yuan, Anderson, Daniel Griffith, Pelet, Jeisa, Langer, Robert S, Khan, Omar Fizal, Dorkin, Joseph Robert
Other Authors: Massachusetts Institute of Technology. Institute for Medical Engineering & Science
Format: Article
Language:en_US
Published: Wiley Blackwell 2016
Online Access:http://hdl.handle.net/1721.1/101132
https://orcid.org/0000-0001-5786-0659
https://orcid.org/0000-0001-5629-4798
https://orcid.org/0000-0001-6898-3793
https://orcid.org/0000-0003-3811-2369
https://orcid.org/0000-0003-4255-0492
Description
Summary:New lipid-like nanomaterials are developed to simultaneously regulate expression of multiple genes. Self-assembled nanoparticles are capable of efficiently encapsulating pDNA and siRNA. These nanoparticles are shown to induce simultaneous gene expression and silencing both in vitro and in vivo.

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