Size- and shape-dependent foreign body immune response to materials implanted in rodents and non-human primates

Size- and shape-dependent foreign body immune response to materials implanted in rodents and non-human primates

The efficacy of implanted biomedical devices is often compromised by host recognition and subsequent foreign body responses. Here, we demonstrate the role of the geometry of implanted materials on their biocompatibility in vivo. In rodent and non-human primate animal models, implanted spheres 1.5 mm...

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Bibliographic Details
Main Authors: Veiseh, Omid, Ma, Minglin, Tam, Hok Hei, Li, Jie, Langan, Erin, Wyckoff, Jeffrey, Loo, Whitney S., Jhunjhunwala, Siddharth, Chiu, Alan, Tang, Katherine, Hollister-Lock, Jennifer, Bochenek, Matthew, Mendoza-Elias, Joshua, Wang, Yong, Qi, Merigeng, Lavin, Danya M., Dholakia, Nimit, Thakrar, Raj, Weir, Gordon C., Oberholzer, Jose, Greiner, Dale L., Vegas, Arturo, Bader, Andrew, Anderson, Daniel Griffith, Lacik, Igor, Thankrar, Raj, Doloff, Joshua C, Siebert, Sean M, Chen, Michael Y, Langer, Robert S, Aresta-Dasilva, Stephanie K
Other Authors: Massachusetts Institute of Technology. Institute for Medical Engineering & Science
Format: Article
Language:en_US
Published: Nature Publishing Group 2016
Online Access:http://hdl.handle.net/1721.1/101142
https://orcid.org/0000-0001-5629-4798
https://orcid.org/0000-0002-4323-3264
https://orcid.org/0000-0003-1520-4180
https://orcid.org/0000-0001-8223-035X
https://orcid.org/0000-0001-9522-8208
https://orcid.org/0000-0002-2358-0330
https://orcid.org/0000-0001-8046-2288
https://orcid.org/0000-0002-5840-2366
https://orcid.org/0000-0003-4255-0492
Description
Summary:The efficacy of implanted biomedical devices is often compromised by host recognition and subsequent foreign body responses. Here, we demonstrate the role of the geometry of implanted materials on their biocompatibility in vivo. In rodent and non-human primate animal models, implanted spheres 1.5 mm and above in diameter across a broad spectrum of materials, including hydrogels, ceramics, metals and plastics, significantly abrogated foreign body reactions and fibrosis when compared with smaller spheres. We also show that for encapsulated rat pancreatic islet cells transplanted into streptozotocin-treated diabetic C57BL/6 mice, islets prepared in 1.5-mm alginate capsules were able to restore blood-glucose control for up to 180 days, a period more than five times longer than for transplanted grafts encapsulated within conventionally sized 0.5-mm alginate capsules. Our findings suggest that the in vivo biocompatibility of biomedical devices can be significantly improved simply by tuning their spherical dimensions.

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