Rapid skin permeabilization by the simultaneous application of dual-frequency, high-intensity ultrasound
Low-frequency ultrasound has been studied extensively due to its ability to enhance skin permeability. In spite of this effort, improvements in enhancing the efficacy of transdermal ultrasound treatments have been limited. Currently, when greater skin permeability is desired at a given frequency, on...
| Main Authors: | , , , , , , , |
|---|---|
| Other Authors: | |
| Format: | Article |
| Language: | en_US |
| Published: |
Elsevier
2016
|
| Online Access: | http://hdl.handle.net/1721.1/101145 https://orcid.org/0000-0001-6694-6761 https://orcid.org/0000-0002-8924-0849 https://orcid.org/0000-0002-7836-415X https://orcid.org/0000-0003-4255-0492 |
| _version_ | 1826206059596873728 |
|---|---|
| author | Polat, Baris E. Mendenhall, Jonathan David Maa, Ruby C. Jones, Brianna Langer, Robert Blankschtein, Daniel Schoellhammer, Carl Hart, Douglas |
| author2 | Massachusetts Institute of Technology. Department of Chemical Engineering |
| author_facet | Massachusetts Institute of Technology. Department of Chemical Engineering Polat, Baris E. Mendenhall, Jonathan David Maa, Ruby C. Jones, Brianna Langer, Robert Blankschtein, Daniel Schoellhammer, Carl Hart, Douglas |
| author_sort | Polat, Baris E. |
| collection | MIT |
| description | Low-frequency ultrasound has been studied extensively due to its ability to enhance skin permeability. In spite of this effort, improvements in enhancing the efficacy of transdermal ultrasound treatments have been limited. Currently, when greater skin permeability is desired at a given frequency, one is limited to increasing the intensity or the duration of the ultrasound treatment, which carries the risk of thermal side effects. Therefore, the ability to increase skin permeability without increasing ultrasound intensity or treatment time would represent a significant and desirable outcome. Here, we hypothesize that the simultaneous application of two distinct ultrasound frequencies, in the range of 20 kHz to 3 MHz, can enhance the efficacy of ultrasound exposure. Aluminum foil pitting experiments showed a significant increase in cavitational activity when two frequencies were applied instead of just one low frequency. Additionally, in vitro tests with porcine skin indicated that the permeability and resulting formation of localized transport regions are greatly enhanced when two frequencies (low and high) are used simultaneously. These results were corroborated with glucose (180 Da) and inulin (5000 Da) transdermal flux experiments, which showed greater permeant delivery both into and through the dual-frequency pre-treated skin. |
| first_indexed | 2024-09-23T13:23:27Z |
| format | Article |
| id | mit-1721.1/101145 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T13:23:27Z |
| publishDate | 2016 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | mit-1721.1/1011452022-09-28T13:51:35Z Rapid skin permeabilization by the simultaneous application of dual-frequency, high-intensity ultrasound Polat, Baris E. Mendenhall, Jonathan David Maa, Ruby C. Jones, Brianna Langer, Robert Blankschtein, Daniel Schoellhammer, Carl Hart, Douglas Massachusetts Institute of Technology. Department of Chemical Engineering Massachusetts Institute of Technology. Department of Materials Science and Engineering Massachusetts Institute of Technology. Department of Mechanical Engineering Koch Institute for Integrative Cancer Research at MIT Schoellhammer, Carl Polat, Baris E. Mendenhall, Jonathan David Maa, Ruby C. Jones, Brianna Hart, Douglas Langer, Robert Blankschtein, Daniel Low-frequency ultrasound has been studied extensively due to its ability to enhance skin permeability. In spite of this effort, improvements in enhancing the efficacy of transdermal ultrasound treatments have been limited. Currently, when greater skin permeability is desired at a given frequency, one is limited to increasing the intensity or the duration of the ultrasound treatment, which carries the risk of thermal side effects. Therefore, the ability to increase skin permeability without increasing ultrasound intensity or treatment time would represent a significant and desirable outcome. Here, we hypothesize that the simultaneous application of two distinct ultrasound frequencies, in the range of 20 kHz to 3 MHz, can enhance the efficacy of ultrasound exposure. Aluminum foil pitting experiments showed a significant increase in cavitational activity when two frequencies were applied instead of just one low frequency. Additionally, in vitro tests with porcine skin indicated that the permeability and resulting formation of localized transport regions are greatly enhanced when two frequencies (low and high) are used simultaneously. These results were corroborated with glucose (180 Da) and inulin (5000 Da) transdermal flux experiments, which showed greater permeant delivery both into and through the dual-frequency pre-treated skin. National Institutes of Health (U.S.) (Grant EB-00351) 2016-02-09T20:01:03Z 2016-02-09T20:01:03Z 2012-08 2012-05 Article http://purl.org/eprint/type/JournalArticle 01683659 http://hdl.handle.net/1721.1/101145 Schoellhammer, Carl M., Baris E. Polat, Jonathan Mendenhall, Ruby Maa, Brianna Jones, Douglas P. Hart, Robert Langer, and Daniel Blankschtein. “Rapid Skin Permeabilization by the Simultaneous Application of Dual-Frequency, High-Intensity Ultrasound.” Journal of Controlled Release 163, no. 2 (October 2012): 154–160. https://orcid.org/0000-0001-6694-6761 https://orcid.org/0000-0002-8924-0849 https://orcid.org/0000-0002-7836-415X https://orcid.org/0000-0003-4255-0492 en_US http://dx.doi.org/10.1016/j.jconrel.2012.08.019 Journal of Controlled Release Creative Commons Attribution-NonCommercial-NoDerivs License http://creativecommons.org/licenses/by-nc-nd/4.0/ application/pdf Elsevier PMC |
| spellingShingle | Polat, Baris E. Mendenhall, Jonathan David Maa, Ruby C. Jones, Brianna Langer, Robert Blankschtein, Daniel Schoellhammer, Carl Hart, Douglas Rapid skin permeabilization by the simultaneous application of dual-frequency, high-intensity ultrasound |
| title | Rapid skin permeabilization by the simultaneous application of dual-frequency, high-intensity ultrasound |
| title_full | Rapid skin permeabilization by the simultaneous application of dual-frequency, high-intensity ultrasound |
| title_fullStr | Rapid skin permeabilization by the simultaneous application of dual-frequency, high-intensity ultrasound |
| title_full_unstemmed | Rapid skin permeabilization by the simultaneous application of dual-frequency, high-intensity ultrasound |
| title_short | Rapid skin permeabilization by the simultaneous application of dual-frequency, high-intensity ultrasound |
| title_sort | rapid skin permeabilization by the simultaneous application of dual frequency high intensity ultrasound |
| url | http://hdl.handle.net/1721.1/101145 https://orcid.org/0000-0001-6694-6761 https://orcid.org/0000-0002-8924-0849 https://orcid.org/0000-0002-7836-415X https://orcid.org/0000-0003-4255-0492 |
| work_keys_str_mv | AT polatbarise rapidskinpermeabilizationbythesimultaneousapplicationofdualfrequencyhighintensityultrasound AT mendenhalljonathandavid rapidskinpermeabilizationbythesimultaneousapplicationofdualfrequencyhighintensityultrasound AT maarubyc rapidskinpermeabilizationbythesimultaneousapplicationofdualfrequencyhighintensityultrasound AT jonesbrianna rapidskinpermeabilizationbythesimultaneousapplicationofdualfrequencyhighintensityultrasound AT langerrobert rapidskinpermeabilizationbythesimultaneousapplicationofdualfrequencyhighintensityultrasound AT blankschteindaniel rapidskinpermeabilizationbythesimultaneousapplicationofdualfrequencyhighintensityultrasound AT schoellhammercarl rapidskinpermeabilizationbythesimultaneousapplicationofdualfrequencyhighintensityultrasound AT hartdouglas rapidskinpermeabilizationbythesimultaneousapplicationofdualfrequencyhighintensityultrasound |