Ultrasound-enhanced transdermal delivery: recent advances and future challenges
The skin is a formidable diffusion barrier that restricts passive diffusion to small (<500 Da) lipophilic molecules. Methods used to permeabilize this barrier for the purpose of drug delivery are maturing as an alternative to oral drug delivery and hypodermic injections. Ultrasound can reversibly...
| Main Authors: | , , , |
|---|---|
| Other Authors: | |
| Format: | Article |
| Language: | en_US |
| Published: |
Future Science, LTD
2016
|
| Online Access: | http://hdl.handle.net/1721.1/101148 https://orcid.org/0000-0001-6694-6761 https://orcid.org/0000-0002-7836-415X https://orcid.org/0000-0003-4255-0492 |
| _version_ | 1826213084670197760 |
|---|---|
| author | Blankschtein, Daniel Oberli, Matthias Langer, Robert S Schoellhammer, Carl Magnus |
| author2 | Massachusetts Institute of Technology. Department of Chemical Engineering |
| author_facet | Massachusetts Institute of Technology. Department of Chemical Engineering Blankschtein, Daniel Oberli, Matthias Langer, Robert S Schoellhammer, Carl Magnus |
| author_sort | Blankschtein, Daniel |
| collection | MIT |
| description | The skin is a formidable diffusion barrier that restricts passive diffusion to small (<500 Da) lipophilic molecules. Methods used to permeabilize this barrier for the purpose of drug delivery are maturing as an alternative to oral drug delivery and hypodermic injections. Ultrasound can reversibly and non-invasively permeabilize the diffusion barrier posed by the skin. This review discusses the mechanisms of ultrasound-permeability enhancement, and presents technological innovations in equipment miniaturization and recent advances in permeabilization capabilities. Additionally, potentially exciting applications, including protein delivery, vaccination, gene therapy and sensing of blood analytes, are discussed. Finally, the future challenges and opportunities associated with the use of ultrasound are discussed. It is stressed that developing ultrasound for suitable applications is key to ensure commercial success. |
| first_indexed | 2024-09-23T15:43:24Z |
| format | Article |
| id | mit-1721.1/101148 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T15:43:24Z |
| publishDate | 2016 |
| publisher | Future Science, LTD |
| record_format | dspace |
| spelling | mit-1721.1/1011482022-09-29T15:45:10Z Ultrasound-enhanced transdermal delivery: recent advances and future challenges Blankschtein, Daniel Oberli, Matthias Langer, Robert S Schoellhammer, Carl Magnus Massachusetts Institute of Technology. Department of Chemical Engineering Koch Institute for Integrative Cancer Research at MIT Oberli, Matthias Schoellhammer, Carl Langer, Robert Blankschtein, Daniel The skin is a formidable diffusion barrier that restricts passive diffusion to small (<500 Da) lipophilic molecules. Methods used to permeabilize this barrier for the purpose of drug delivery are maturing as an alternative to oral drug delivery and hypodermic injections. Ultrasound can reversibly and non-invasively permeabilize the diffusion barrier posed by the skin. This review discusses the mechanisms of ultrasound-permeability enhancement, and presents technological innovations in equipment miniaturization and recent advances in permeabilization capabilities. Additionally, potentially exciting applications, including protein delivery, vaccination, gene therapy and sensing of blood analytes, are discussed. Finally, the future challenges and opportunities associated with the use of ultrasound are discussed. It is stressed that developing ultrasound for suitable applications is key to ensure commercial success. National Institutes of Health (U.S.) (Grant EB-00351) National Institutes of Health (U.S.) (Grant CA014051) Swiss National Science Foundation (Grant PA002_14059) 2016-02-09T20:30:23Z 2016-02-09T20:30:23Z 2014-07 Article http://purl.org/eprint/type/JournalArticle 2041-5990 2041-6008 http://hdl.handle.net/1721.1/101148 Oberli, Matthias A, Carl M Schoellhammer, Robert Langer, and Daniel Blankschtein. “Ultrasound-Enhanced Transdermal Delivery: Recent Advances and Future Challenges.” Therapeutic Delivery 5, no. 7 (July 2014): 843–57. https://orcid.org/0000-0001-6694-6761 https://orcid.org/0000-0002-7836-415X https://orcid.org/0000-0003-4255-0492 en_US http://dx.doi.org/10.4155/tde.14.32 Therapeutic Delivery Creative Commons Attribution-Noncommercial-Share Alike http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf Future Science, LTD PMC |
| spellingShingle | Blankschtein, Daniel Oberli, Matthias Langer, Robert S Schoellhammer, Carl Magnus Ultrasound-enhanced transdermal delivery: recent advances and future challenges |
| title | Ultrasound-enhanced transdermal delivery: recent advances and future challenges |
| title_full | Ultrasound-enhanced transdermal delivery: recent advances and future challenges |
| title_fullStr | Ultrasound-enhanced transdermal delivery: recent advances and future challenges |
| title_full_unstemmed | Ultrasound-enhanced transdermal delivery: recent advances and future challenges |
| title_short | Ultrasound-enhanced transdermal delivery: recent advances and future challenges |
| title_sort | ultrasound enhanced transdermal delivery recent advances and future challenges |
| url | http://hdl.handle.net/1721.1/101148 https://orcid.org/0000-0001-6694-6761 https://orcid.org/0000-0002-7836-415X https://orcid.org/0000-0003-4255-0492 |
| work_keys_str_mv | AT blankschteindaniel ultrasoundenhancedtransdermaldeliveryrecentadvancesandfuturechallenges AT oberlimatthias ultrasoundenhancedtransdermaldeliveryrecentadvancesandfuturechallenges AT langerroberts ultrasoundenhancedtransdermaldeliveryrecentadvancesandfuturechallenges AT schoellhammercarlmagnus ultrasoundenhancedtransdermaldeliveryrecentadvancesandfuturechallenges |