Mathematical modeling of drug delivery from autocatalytically degradable PLGA microspheres — A review
PLGA microspheres are widely studied for controlled release drug delivery applications, and many models have been proposed to describe PLGA degradation and erosion and drug release from the bulk polymer. Autocatalysis is known to have a complex role in the dynamics of PLGA erosion and drug transport...
| Main Authors: | , , |
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| Other Authors: | |
| Format: | Article |
| Language: | en_US |
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Elsevier
2016
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| Online Access: | http://hdl.handle.net/1721.1/101153 https://orcid.org/0000-0003-4304-3484 |
| _version_ | 1826210392855019520 |
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| author | Ford Versypt, Ashlee N. Pack, Daniel W. Braatz, Richard D. |
| author2 | Massachusetts Institute of Technology. Department of Chemical Engineering |
| author_facet | Massachusetts Institute of Technology. Department of Chemical Engineering Ford Versypt, Ashlee N. Pack, Daniel W. Braatz, Richard D. |
| author_sort | Ford Versypt, Ashlee N. |
| collection | MIT |
| description | PLGA microspheres are widely studied for controlled release drug delivery applications, and many models have been proposed to describe PLGA degradation and erosion and drug release from the bulk polymer. Autocatalysis is known to have a complex role in the dynamics of PLGA erosion and drug transport and can lead to size-dependent heterogeneities in otherwise uniformly bulk-eroding polymer microspheres. The aim of this review is to highlight mechanistic, mathematical models for drug release from PLGA microspheres that specifically address interactions between phenomena generally attributed to autocatalytic hydrolysis and mass transfer limitation effects. Predictions of drug release profiles by mechanistic models are useful for understanding mechanisms and designing drug release particles. |
| first_indexed | 2024-09-23T14:49:05Z |
| format | Article |
| id | mit-1721.1/101153 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T14:49:05Z |
| publishDate | 2016 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | mit-1721.1/1011532022-09-29T10:46:20Z Mathematical modeling of drug delivery from autocatalytically degradable PLGA microspheres — A review Ford Versypt, Ashlee N. Pack, Daniel W. Braatz, Richard D. Massachusetts Institute of Technology. Department of Chemical Engineering Ford Versypt, Ashlee N. Braatz, Richard D. PLGA microspheres are widely studied for controlled release drug delivery applications, and many models have been proposed to describe PLGA degradation and erosion and drug release from the bulk polymer. Autocatalysis is known to have a complex role in the dynamics of PLGA erosion and drug transport and can lead to size-dependent heterogeneities in otherwise uniformly bulk-eroding polymer microspheres. The aim of this review is to highlight mechanistic, mathematical models for drug release from PLGA microspheres that specifically address interactions between phenomena generally attributed to autocatalytic hydrolysis and mass transfer limitation effects. Predictions of drug release profiles by mechanistic models are useful for understanding mechanisms and designing drug release particles. National Institutes of Health (U.S.) (NIBIB 5RO1EB005181) National Science Foundation (U.S.) (Grant 0426328) United States. Dept. of Energy. National Nuclear Security Administration (Contract DE-FG02-97ER25308) 2016-02-11T01:27:56Z 2016-02-11T01:27:56Z 2012-10 2012-09 Article http://purl.org/eprint/type/JournalArticle 01683659 http://hdl.handle.net/1721.1/101153 Ford Versypt, Ashlee N., Daniel W. Pack, and Richard D. Braatz. “Mathematical Modeling of Drug Delivery from Autocatalytically Degradable PLGA Microspheres — A Review.” Journal of Controlled Release 165, no. 1 (January 2013): 29–37. https://orcid.org/0000-0003-4304-3484 en_US http://dx.doi.org/10.1016/j.jconrel.2012.10.015 Journal of Controlled Release Creative Commons Attribution-NonCommercial-NoDerivs License http://creativecommons.org/licenses/by-nc-nd/4.0/ application/pdf Elsevier PMC |
| spellingShingle | Ford Versypt, Ashlee N. Pack, Daniel W. Braatz, Richard D. Mathematical modeling of drug delivery from autocatalytically degradable PLGA microspheres — A review |
| title | Mathematical modeling of drug delivery from autocatalytically degradable PLGA microspheres — A review |
| title_full | Mathematical modeling of drug delivery from autocatalytically degradable PLGA microspheres — A review |
| title_fullStr | Mathematical modeling of drug delivery from autocatalytically degradable PLGA microspheres — A review |
| title_full_unstemmed | Mathematical modeling of drug delivery from autocatalytically degradable PLGA microspheres — A review |
| title_short | Mathematical modeling of drug delivery from autocatalytically degradable PLGA microspheres — A review |
| title_sort | mathematical modeling of drug delivery from autocatalytically degradable plga microspheres a review |
| url | http://hdl.handle.net/1721.1/101153 https://orcid.org/0000-0003-4304-3484 |
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