Light microscopy mapping of connections in the intact brain
Mapping of neural connectivity across the mammalian brain is a daunting and exciting prospect. Current approaches can be divided into three classes: macroscale, focusing on coarse inter-regional connectivity; mesoscale, involving a finer focus on neurons and projections; and microscale, reconstructi...
| Main Authors: | , , |
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| Other Authors: | |
| Format: | Article |
| Language: | en_US |
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Elsevier
2016
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| Online Access: | http://hdl.handle.net/1721.1/101194 https://orcid.org/0000-0002-8167-3340 |
| _version_ | 1826198544333144064 |
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| author | Kim, Sung-Yon Chung, Kwanghun Deisseroth, Karl |
| author2 | Massachusetts Institute of Technology. Institute for Medical Engineering & Science |
| author_facet | Massachusetts Institute of Technology. Institute for Medical Engineering & Science Kim, Sung-Yon Chung, Kwanghun Deisseroth, Karl |
| author_sort | Kim, Sung-Yon |
| collection | MIT |
| description | Mapping of neural connectivity across the mammalian brain is a daunting and exciting prospect. Current approaches can be divided into three classes: macroscale, focusing on coarse inter-regional connectivity; mesoscale, involving a finer focus on neurons and projections; and microscale, reconstructing full details of all synaptic contacts. It remains to be determined how to bridge the datasets or insights from the different levels of study. Here we review recent light-microscopy-based approaches that may help in integration across scales. |
| first_indexed | 2024-09-23T11:06:32Z |
| format | Article |
| id | mit-1721.1/101194 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T11:06:32Z |
| publishDate | 2016 |
| publisher | Elsevier |
| record_format | dspace |
| spelling | mit-1721.1/1011942022-10-01T01:18:41Z Light microscopy mapping of connections in the intact brain Kim, Sung-Yon Chung, Kwanghun Deisseroth, Karl Massachusetts Institute of Technology. Institute for Medical Engineering & Science Massachusetts Institute of Technology. Department of Chemical Engineering Picower Institute for Learning and Memory Chung, Kwanghun Kim, Sung-Yon Chung, Kwanghun Mapping of neural connectivity across the mammalian brain is a daunting and exciting prospect. Current approaches can be divided into three classes: macroscale, focusing on coarse inter-regional connectivity; mesoscale, involving a finer focus on neurons and projections; and microscale, reconstructing full details of all synaptic contacts. It remains to be determined how to bridge the datasets or insights from the different levels of study. Here we review recent light-microscopy-based approaches that may help in integration across scales. 2016-02-17T14:49:21Z 2016-02-17T14:49:21Z 2013-11 Article http://purl.org/eprint/type/JournalArticle 13646613 http://hdl.handle.net/1721.1/101194 Kim, Sung-Yon, Kwanghun Chung, and Karl Deisseroth. “Light Microscopy Mapping of Connections in the Intact Brain.” Trends in Cognitive Sciences 17, no. 12 (December 2013): 596–599. https://orcid.org/0000-0002-8167-3340 en_US http://dx.doi.org/10.1016/j.tics.2013.10.005 Trends in Cognitive Sciences Creative Commons Attribution-NonCommercial-NoDerivs License http://creativecommons.org/licenses/by-nc-nd/4.0/ application/pdf Elsevier Prof. Chung via Erja Kajosalo |
| spellingShingle | Kim, Sung-Yon Chung, Kwanghun Deisseroth, Karl Light microscopy mapping of connections in the intact brain |
| title | Light microscopy mapping of connections in the intact brain |
| title_full | Light microscopy mapping of connections in the intact brain |
| title_fullStr | Light microscopy mapping of connections in the intact brain |
| title_full_unstemmed | Light microscopy mapping of connections in the intact brain |
| title_short | Light microscopy mapping of connections in the intact brain |
| title_sort | light microscopy mapping of connections in the intact brain |
| url | http://hdl.handle.net/1721.1/101194 https://orcid.org/0000-0002-8167-3340 |
| work_keys_str_mv | AT kimsungyon lightmicroscopymappingofconnectionsintheintactbrain AT chungkwanghun lightmicroscopymappingofconnectionsintheintactbrain AT deisserothkarl lightmicroscopymappingofconnectionsintheintactbrain |