Self-assembled hydrogels utilizing polymer–nanoparticle interactions
Mouldable hydrogels that flow on applied stress and rapidly self-heal are increasingly utilized as they afford minimally invasive delivery and conformal application. Here we report a new paradigm for the fabrication of self-assembled hydrogels with shear-thinning and self-healing properties employin...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | en_US |
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Nature Publishing Group
2016
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| Online Access: | http://hdl.handle.net/1721.1/101204 https://orcid.org/0000-0002-4917-7187 https://orcid.org/0000-0003-0624-3532 https://orcid.org/0000-0002-2301-7126 https://orcid.org/0000-0003-4255-0492 |
| _version_ | 1826216693941141504 |
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| author | Mattix, Bradley A. Veiseh, Omid Webber, Matthew Tibbitt, Mark W Langer, Robert S Appel, Eric |
| author2 | Massachusetts Institute of Technology. Department of Chemical Engineering |
| author_facet | Massachusetts Institute of Technology. Department of Chemical Engineering Mattix, Bradley A. Veiseh, Omid Webber, Matthew Tibbitt, Mark W Langer, Robert S Appel, Eric |
| author_sort | Mattix, Bradley A. |
| collection | MIT |
| description | Mouldable hydrogels that flow on applied stress and rapidly self-heal are increasingly utilized as they afford minimally invasive delivery and conformal application. Here we report a new paradigm for the fabrication of self-assembled hydrogels with shear-thinning and self-healing properties employing rationally engineered polymer–nanoparticle (NP) interactions. Biopolymer derivatives are linked together by selective adsorption to NPs. The transient and reversible interactions between biopolymers and NPs enable flow under applied shear stress, followed by rapid self-healing when the stress is relaxed. We develop a physical description of polymer–NP gel formation that is utilized to design biocompatible gels for drug delivery. Owing to the hierarchical structure of the gel, both hydrophilic and hydrophobic drugs can be entrapped and delivered with differential release profiles, both in vitro and in vivo. The work introduces a facile and generalizable class of mouldable hydrogels amenable to a range of biomedical and industrial applications. |
| first_indexed | 2024-09-23T16:51:54Z |
| format | Article |
| id | mit-1721.1/101204 |
| institution | Massachusetts Institute of Technology |
| language | en_US |
| last_indexed | 2024-09-23T16:51:54Z |
| publishDate | 2016 |
| publisher | Nature Publishing Group |
| record_format | dspace |
| spelling | mit-1721.1/1012042022-10-03T08:47:55Z Self-assembled hydrogels utilizing polymer–nanoparticle interactions Mattix, Bradley A. Veiseh, Omid Webber, Matthew Tibbitt, Mark W Langer, Robert S Appel, Eric Massachusetts Institute of Technology. Department of Chemical Engineering Massachusetts Institute of Technology. Department of Materials Science and Engineering Koch Institute for Integrative Cancer Research at MIT Appel, Eric Andrew Tibbitt, Mark W. Webber, Matthew Mattix, Bradley A. Veiseh, Omid Langer, Robert Mouldable hydrogels that flow on applied stress and rapidly self-heal are increasingly utilized as they afford minimally invasive delivery and conformal application. Here we report a new paradigm for the fabrication of self-assembled hydrogels with shear-thinning and self-healing properties employing rationally engineered polymer–nanoparticle (NP) interactions. Biopolymer derivatives are linked together by selective adsorption to NPs. The transient and reversible interactions between biopolymers and NPs enable flow under applied shear stress, followed by rapid self-healing when the stress is relaxed. We develop a physical description of polymer–NP gel formation that is utilized to design biocompatible gels for drug delivery. Owing to the hierarchical structure of the gel, both hydrophilic and hydrophobic drugs can be entrapped and delivered with differential release profiles, both in vitro and in vivo. The work introduces a facile and generalizable class of mouldable hydrogels amenable to a range of biomedical and industrial applications. Wellcome Trust-MIT Postdoctoral Fellowship Misrock Foundation (Cancer Nanotechnology Postdoctoral Fellowship) United States. Dept. of Defense. Congressionally Directed Medical Research Programs (Postdoctoral Fellowship Award W81XWH-13-1-0215) National Institutes of Health (U.S.) (NIH-R01 DE016516) 2016-02-17T21:35:55Z 2016-02-17T21:35:55Z 2015-02 2014-04 Article http://purl.org/eprint/type/JournalArticle 2041-1723 http://hdl.handle.net/1721.1/101204 Appel, Eric A., Mark W. Tibbitt, Matthew J. Webber, Bradley A. Mattix, Omid Veiseh, and Robert Langer. “Self-Assembled Hydrogels Utilizing Polymer–nanoparticle Interactions.” Nat Comms 6 (February 19, 2015): 6295. https://orcid.org/0000-0002-4917-7187 https://orcid.org/0000-0003-0624-3532 https://orcid.org/0000-0002-2301-7126 https://orcid.org/0000-0003-4255-0492 en_US http://dx.doi.org/10.1038/ncomms7295 Nature Communications Creative Commons Attribution-Noncommercial-Share Alike http://creativecommons.org/licenses/by-nc-sa/4.0/ application/pdf Nature Publishing Group PMC |
| spellingShingle | Mattix, Bradley A. Veiseh, Omid Webber, Matthew Tibbitt, Mark W Langer, Robert S Appel, Eric Self-assembled hydrogels utilizing polymer–nanoparticle interactions |
| title | Self-assembled hydrogels utilizing polymer–nanoparticle interactions |
| title_full | Self-assembled hydrogels utilizing polymer–nanoparticle interactions |
| title_fullStr | Self-assembled hydrogels utilizing polymer–nanoparticle interactions |
| title_full_unstemmed | Self-assembled hydrogels utilizing polymer–nanoparticle interactions |
| title_short | Self-assembled hydrogels utilizing polymer–nanoparticle interactions |
| title_sort | self assembled hydrogels utilizing polymer nanoparticle interactions |
| url | http://hdl.handle.net/1721.1/101204 https://orcid.org/0000-0002-4917-7187 https://orcid.org/0000-0003-0624-3532 https://orcid.org/0000-0002-2301-7126 https://orcid.org/0000-0003-4255-0492 |
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