Identification of drug resistance mutations in HIV from constraints on natural evolution
Human immunodeficiency virus (HIV) evolves with extraordinary rapidity. However, its evolution is constrained by interactions between mutations in its fitness landscape. Here we show that an Ising model describing these interactions, inferred from sequence data obtained prior to the use of antiretro...
| Main Authors: | , , , |
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| Other Authors: | |
| Format: | Article |
| Language: | English |
| Published: |
American Physical Society
2016
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| Online Access: | http://hdl.handle.net/1721.1/101231 https://orcid.org/0000-0003-1467-421X https://orcid.org/0000-0003-1268-9602 https://orcid.org/0000-0002-1112-5912 |