Pyruvate Kinase Isoform Expression Alters Nucleotide Synthesis to Impact Cell Proliferation

Pyruvate Kinase Isoform Expression Alters Nucleotide Synthesis to Impact Cell Proliferation

Metabolic regulation influences cell proliferation. The influence of pyruvate kinase isoforms on tumor cells has been extensively studied, but whether PKM2 is required for normal cell proliferation is unknown. We examine how PKM2 deletion affects proliferation and metabolism in nontransformed, nonim...

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Bibliographic Details
Main Authors: Lunt, Sophia Y., Muralidhar, Vinayak, Israelsen, William J., Newhouse, Lauren, Ogrodzinski, Martin, Xu, Kali, Hollern, Daniel P., Bellinger, Gary, Christen, Stefan, Elia, Ilaria, Dinh, Anh T., Stephanopoulos, Gregory, Manalis, Scott R., Yaffe, Michael B., Andrechek, Eran R., Fendt, Sarah-Maria, Vander Heiden, Matthew G., Hosios, Aaron Marc, Gui, Dan Yi, Acevedo, Paula N. Marin, Dayton, Talya Lucia, Lunt, Sophia Y., Dinh, Anh T., Vander Heiden, Matthew G., Manalis, Scott R, Yaffe, Michael B, Hecht, Vivian Chaya
Other Authors: Harvard University--MIT Division of Health Sciences and Technology
Format: Article
Language:en_US
Published: Elsevier 2016
Online Access:http://hdl.handle.net/1721.1/101246
https://orcid.org/0000-0001-5223-9433
https://orcid.org/0000-0002-7702-5877
https://orcid.org/0000-0002-6702-4192
https://orcid.org/0000-0002-6493-9012
https://orcid.org/0000-0003-0130-3428
https://orcid.org/0000-0003-4110-1388
https://orcid.org/0000-0002-9547-3251
https://orcid.org/0000-0001-6909-4568
https://orcid.org/0000-0002-7994-7963

Internet

http://hdl.handle.net/1721.1/101246
https://orcid.org/0000-0001-5223-9433
https://orcid.org/0000-0002-7702-5877
https://orcid.org/0000-0002-6702-4192
https://orcid.org/0000-0002-6493-9012
https://orcid.org/0000-0003-0130-3428
https://orcid.org/0000-0003-4110-1388
https://orcid.org/0000-0002-9547-3251
https://orcid.org/0000-0001-6909-4568
https://orcid.org/0000-0002-7994-7963

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